Protein

MCA_00157_1

Length
379 amino acids

Gene name: PPM1

Description: Leucine carboxyl methyltransferase 1

Browser: contigA:428007-429209-

RNA-seq: read pairs 1263, FPKM 41.1, percentile rank 60.8% (100% = highest expression)

Protein function

Annotation:PPM1Leucine carboxyl methyltransferase 1
KEGG:K18203LCMT1 [phosphatase 2A protein]-leucine-carboxy methyltransferase [EC:2.1.1.233]
EGGNOG:0PKRDPPM1Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues
SGD closest match:S000002843PPM1Leucine carboxyl methyltransferase 1
CGD closest match:CAL0000196930PPM1Leucine carboxyl methyltransferase 1

Protein alignments

%idAln lengthE-value
MIA_00505_160.78%3578e-148MIA_00505_1
A0A0J9XAX2_GEOCN53.02%3644e-119Similar to Saccharomyces cerevisiae YDR435C PPM1 Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p) OS=Geotrichum candidum GN=BN980_GECA07s03002g PE=4 SV=1
UniRef50_A0A0J9XAX253.02%3648e-116Similar to Saccharomyces cerevisiae YDR435C PPM1 Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p) n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XAX2_GEOCN
A0A060SYK3_BLAAD48.64%3312e-107ARAD1A12980p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A12980g PE=4 SV=1
LCMT1_YARLI45.02%3317e-85Leucine carboxyl methyltransferase 1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PPM1 PE=3 SV=1
A0A1E3PKK5_9ASCO42.73%3445e-85Leucine carboxyl methyltransferase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_11095 PE=4 SV=1
A0A167CFC1_9ASCO50.77%2603e-79Ppm1p OS=Sugiyamaella lignohabitans GN=PPM1 PE=4 SV=1
LCMT1_CANAL36.23%3451e-68Leucine carboxyl methyltransferase 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PPM1 PE=3 SV=1
A0A1E4TF98_9ASCO34.90%3418e-55Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_105161 PE=4 SV=1
LCMT1_YEAST32.13%3338e-39Leucine carboxyl methyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PPM1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4995
Predicted cleavage: 34

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 379

Detailed signature matches

  1. Family IPR007213
    Methyltransferase Ppm1/Ppm2/Tcmp
    1. PF04072 (LCM)
  2. Family IPR016651
    Leucine carboxyl methyltransferase 1, LCMT1
    1. PIRSF016305 (LCMT)
  3. Domain IPR029063
    S-adenosyl-L-methionine-dependent methyltransferase
    1. SSF53335 (S-adenosy...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. mobidb-lite (disord...)

Protein sequence

>MCA_00157_1
MSDQKNNYSSSNPQRLKSLMPHNGAHPPPLGRLSTGPRIPKRDKIIQSTDIDALSSKYSAYMKGYLHDPFLQDIVDGIKQ
HSSPRERVASSFIAKLPVINIGSYIRNYVINCIIESMLQSVSGKAQIISLGAGSDTRAFNIFSKYGSNKVVFHEIDFSVT
TTKKIQTIVSTPKISQLIWESQNVPTELSDEIHTRHYHLHARDLRTIQATSPLLEGMDTSLPTLVISECCLCYLQPEESD
AVLHWLSSNFQNNLSITVYEPIGGNDSFGQVMIENLASRGISLPTLKQFPTLESQVNRLDQKGFTDSSHKFAAAADIWYI
FESWIPDSEKERISKLEVLDEIEELSLLLKHYCISWAVKTTNAEWVSCLEKFPNQVKSA

GO term prediction

Biological Process

GO:0032259 methylation

Molecular Function

GO:0008168 methyltransferase activity

Cellular Component

None predicted.