Protein

MIA_00495_1

Length
299 amino acids

Browser: contig01:1430734-1431844+

Protein function

EGGNOG:0PFFJPGUG_02689The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
SGD closest match:S000004199PNP1Purine nucleoside phosphorylase
CGD closest match:CAL0000198365PNP1Purine nucleoside phosphorylase

Protein alignments

%idAln lengthE-value
MCA_00144_176.254%2999.11e-172MCA_00144_1
A0A0J9X6E3_GEOCN70.432%3011.33e-162Purine nucleoside phosphorylase OS=Geotrichum candidum GN=BN980_GECA04s02969g PE=3 SV=1
A0A060T5F1_BLAAD64.068%2956.09e-142Purine nucleoside phosphorylase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B06600g PE=3 SV=1
Q6BZX6_YARLI58.923%2971.61e-130Purine nucleoside phosphorylase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F30129g PE=3 SV=1
A0A1E3PE47_9ASCO57.432%2965.76e-129Purine nucleoside phosphorylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53795 PE=3 SV=1
A0A1D8PJL8_CANAL60.351%2851.54e-125Purine nucleoside phosphorylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PNP1 PE=3 SV=1
UniRef50_Q9UTG154.362%2981.01e-112Putative purine nucleoside phosphorylase n=102 Tax=cellular organisms TaxID=131567 RepID=PNPH_SCHPO
A0A167DBA2_9ASCO60.417%2402.51e-109Purine-nucleoside phosphorylase OS=Sugiyamaella lignohabitans GN=PNP1 PE=4 SV=1
A0A1E4TJD6_9ASCO51.171%2995.48e-108Purine nucleoside phosphorylase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30169 PE=3 SV=1
PNPH_YEAST52.982%2851.08e-100Purine nucleoside phosphorylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PNP1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0445

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 299

Detailed signature matches

  1. Family IPR011268
    Purine nucleoside phosphorylase
    1. TIGR01697
    2. PIRSF000477 (PurNPase)
  2. Domain IPR000845
    Nucleoside phosphorylase domain
    1. SSF53167 (Purine an...)
    2. PF01048 (PNP_UDP_1)
  3. SITE IPR018099
    Purine phosphorylase, family 2, conserved site
    1. PS01240 (PNP_MTAP_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. TMhelix

Protein sequence

>MIA_00495_1
MTEIYENAKKGADFIVSKYPENFTTPRVAIICGTGLGGIANILHSDSKVEIPYGEIPGFMKSTVQGHAGKLILGYIGLNK
VPVVCMVGRFHSYEGYDIKDTVFPVRVFTVLGVSVLIATNAAGGLNQSFSIGDIMVIDDHINIPGLAGLHPLKGYNDERF
GTRFQPLSDAYDHELRSLVYEGAESLKISRSIHEGTYAFVSGPTFETRAECRYLQTIGADVVGMSTVPEIIVARHGGLRT
LAMSLVTNVAVIDKPPTGKEKLPEKKMDDGIASHEEVLEAGKAASKDIEQIVKYVVNSL

GO term prediction

Biological Process

GO:0006139 nucleobase-containing compound metabolic process
GO:0009116 nucleoside metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004731 purine-nucleoside phosphorylase activity
GO:0016763 transferase activity, transferring pentosyl groups

Cellular Component

None predicted.