Protein

MIA_00490_1

Length
425 amino acids

Browser: contig01:1415695-1416973-

Protein function

EGGNOG:0PIPFNTG2DNA repair protein
SGD closest match:S000000013NTG1Endonuclease III homolog 1
CGD closest match:CAL0000179989NTG1Endonuclease III homolog

Protein alignments

%idAln lengthE-value
MCA_01390_157.096%3039.99e-98MCA_01390_1
A0A0J9XEF5_GEOCN49.432%3521.02e-90Endonuclease III homolog OS=Geotrichum candidum GN=NTG1 PE=3 SV=1
UniRef50_A0A0J9XEF549.432%3522.08e-87Endonuclease III homolog n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9XEF5_GEOCN
A0A167E6Y5_9ASCO52.381%2527.17e-79Endonuclease III homolog OS=Sugiyamaella lignohabitans GN=NTG2 PE=3 SV=1
A0A060TC13_BLAAD44.729%3511.00e-77Endonuclease III homolog OS=Blastobotrys adeninivorans GN=NTG1 PE=3 SV=1
Q6C305_YARLI43.307%3813.33e-74Endonuclease III homolog OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=NTG1 PE=3 SV=1
A0A1D8PE92_CANAL48.790%2481.48e-65Endonuclease III homolog OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NTG1 PE=3 SV=1
A0A1E4TKB5_9ASCO47.881%2361.29e-60Endonuclease III homolog OS=Tortispora caseinolytica NRRL Y-17796 GN=NTG1 PE=3 SV=1
NTH1_YEAST42.083%2401.51e-49Endonuclease III homolog 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NTG1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6015
Predicted cleavage: 17

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 425

Detailed signature matches

  1. Family IPR030841
    Endonuclease III-like protein 1
    1. MF_03183 (Endonucle...)
  2. Domain IPR011257
    DNA glycosylase
    1. SSF48150 (DNA-glyco...)
  3. Domain IPR003265
    HhH-GPD domain
    1. SM00478 (endo3end)
    2. PF00730 (HhH-GPD)
    3. cd00056 (ENDO3c)
  4. Domain IPR023170
    Helix-turn-helix, base-excision DNA repair, C-terminal
    1. G3DSA:1.10.16...
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.34...
  2. mobidb-lite (disord...)

Residue annotation

  1. minor groove readi...
  2. helix-hairpin-heli...
  3. substrate binding ...
  4. active site cd00056

Protein sequence

>MIA_00490_1
MTSEIVSLRKSARIRARSERNGSGDVNNEDEESEYFSRQPNKKKKKESKKTVDLPTVKTEFLNKSVGIKLEEEHKVKKEP
VQHVEIKMEDNSEYNDLPSVVNTEIKVKTEIAGNEIKQEEEKYELCDSPLAGEYAQRPANPYVPAFSRIKFFQKYQNDSP
GPAGWREIYARVKEMRAHTIAPVDTMGCERLPEKMYEEASNEGVHPTVHRFQLLVSLLLSSQTKDAVTAAAVAALRSGLR
VDPITGRGGLTVGTVLATPENEIDELIGKVGFHRRKAGYLLRVAQQLREKYGDDIPETLREIVGLPGIGPKMGHLLVQRA
WGRVEGIGVDVHVHRLSRQWGWVKKKKKGEEDNDGDPEATRAGLEEWLPQDLWLDINPQLVGFGQTLCPSRGKRCGDCLI
SGSGLCRADTGDDVRKKRTNGQKKA

GO term prediction

Biological Process

GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006285 base-excision repair, AP site formation

Molecular Function

GO:0003824 catalytic activity
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0019104 DNA N-glycosylase activity

Cellular Component

GO:0005634 nucleus