Protein

MCA_01390_1

Length
417 amino acids

Gene name: NTG1

Description: Endonuclease III homolog

Browser: contigA:4344445-4345699-

RNA-seq: read pairs 1127, FPKM 33.3, percentile rank 55.5% (100% = highest expression)

Protein function

Annotation:NTG1Endonuclease III homolog
KEGG:K10773NTH endonuclease III [EC:4.2.99.18]
EGGNOG:0PIPFNTG2DNA repair protein
SGD closest match:S000000013NTG1Endonuclease III homolog 1
CGD closest match:CAL0000179989NTG1Endonuclease III homolog

Protein alignments

%idAln lengthE-value
MIA_00490_156.45%3103e-105MIA_00490_1
A0A0J9XEF5_GEOCN46.13%3751e-98Endonuclease III homolog OS=Geotrichum candidum GN=NTG1 PE=3 SV=1
UniRef50_A0A0J9XEF546.13%3752e-95Endonuclease III homolog n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9XEF5_GEOCN
A0A167E6Y5_9ASCO48.36%3041e-92Endonuclease III homolog OS=Sugiyamaella lignohabitans GN=NTG2 PE=3 SV=1
A0A060TC13_BLAAD49.47%2852e-92Endonuclease III homolog OS=Blastobotrys adeninivorans GN=NTG1 PE=3 SV=1
Q6C305_YARLI46.85%2862e-79Endonuclease III homolog OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=NTG1 PE=3 SV=1
A0A1D8PE92_CANAL42.81%3271e-79Endonuclease III homolog OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NTG1 PE=3 SV=1
A0A1E4TKB5_9ASCO50.94%2125e-69Endonuclease III homolog OS=Tortispora caseinolytica NRRL Y-17796 GN=NTG1 PE=3 SV=1
NTH1_YEAST40.00%2851e-61Endonuclease III homolog 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NTG1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8759

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 417

Detailed signature matches

  1. Family IPR030841
    Endonuclease III-like protein 1
    1. MF_03183 (Endonucle...)
  2. Domain IPR011257
    DNA glycosylase
    1. SSF48150 (DNA-glyco...)
  3. Domain IPR003265
    HhH-GPD domain
    1. SM00478 (endo3end)
    2. PF00730 (HhH-GPD)
    3. cd00056 (ENDO3c)
  4. Domain IPR023170
    Helix-turn-helix, base-excision DNA repair, C-terminal
    1. G3DSA:1.10.16...
  5. SITE IPR000445
    Helix-hairpin-helix motif
    1. PF00633 (HHH)
  6. SITE IPR004036
    Endonuclease III-like, conserved site-2
    1. PS01155 (ENDONUCLEA...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.34...
  2. mobidb-lite (disord...)

Residue annotation

  1. minor groove readi...
  2. helix-hairpin-heli...
  3. substrate binding ...
  4. active site cd00056

Protein sequence

>MCA_01390_1
MRKMVEQSAGMVSSRTRNGIKSIDKYAYNSSNKVNSIGQHQMNKRKINATDTTSEYFEKKIKIEPTSVGPDLHFSDTHIK
DEPFEDTKRRILNHIDIEFDSSPNPDLNTNPYLKPFDKDEFFKLHPTDEPGPPGWRTIYALVKEMRSYTIAPVDTMGCER
IPESIKIEASDGDLKTEDKDSAAFIKQEANGITRNYESKGVSPEVYRFQLLVGLLLSSQTKDQVTSAAVESLRQGLNPDN
TTGERGLTIGTVEATSEEKIDSLICKVGFHKRKAGYLKSIAPILREKYNGDIPDTIDGMVSLPGIGPKMAHLLIQRAWGK
VEGIGVDVHVDRLSRLWKWTSSKKRGRDAGDTQKSRSSPEETRQQLEQWLPKDLWVDINPTLVGFGQTICPSRGTKCDQC
LVARTNLCSGNKLKKSL

GO term prediction

Biological Process

GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006285 base-excision repair, AP site formation

Molecular Function

GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0019104 DNA N-glycosylase activity

Cellular Component

GO:0005634 nucleus