Protein

MIA_00476_1

Length
443 amino acids

Browser: contig01:1364910-1366242+

Protein function

EGGNOG:0PJ45TRM61Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA
SGD closest match:S000003661GCD14tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61
CGD closest match:CAL0000194641TRM61tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61

Protein alignments

%idAln lengthE-value
MCA_04776_158.744%4460.0MCA_04776_1
A0A0J9XH32_GEOCN53.759%4391.86e-162tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Geotrichum candidum GN=BN980_GECA16s02155g PE=3 SV=1
UniRef50_A0A0J9XH3253.759%4393.81e-159tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 n=6 Tax=Ascomycota TaxID=4890 RepID=A0A0J9XH32_GEOCN
A0A060TD05_BLAAD52.019%4213.07e-154tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B20152g PE=3 SV=1
A0A1E3PFY5_9ASCO49.654%4331.05e-146tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_27029 PE=3 SV=1
A0A167FWG3_9ASCO48.349%4244.30e-145tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Sugiyamaella lignohabitans GN=GCD14 PE=3 SV=1
TRM61_YARLI45.139%4322.36e-125tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TRM61 PE=3 SV=1
TRM61_CANAL45.000%4201.01e-122tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TRM61 PE=3 SV=1
TRM61_YEAST43.810%4202.53e-118tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GCD14 PE=1 SV=1
A0A1E4TC21_9ASCO42.453%4243.65e-107tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32610 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0209

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 443

Detailed signature matches

  1. Family IPR014816
    tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14
    1. PF08704 (GCD14)
    2. PS51620 (SAM_TRM61)
  2. Domain IPR029063
    S-adenosyl-L-methionine-dependent methyltransferase
    1. SSF53335 (S-adenosy...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.10.33...
  3. G3DSA:3.40.50...
  4. mobidb-lite (disord...)

Protein sequence

>MIA_00476_1
MAFFSYTEYIKEGDLVLAWMNRANIRPFTVTCGEILHTQYGSFPHDTLIGVKYGTQVGSTAGASGGHDAKRGPSSRGHGS
ATGFIHVLAPTPELWSLSLRHRTQIVYTPDASYIVQRLRIRPGSRVLEAGTGSGSFTHALSRTVGTSGQLFTYEFHGPRY
EEALQEVAADGINLNTVITHRDVCAEGFDNPTIANSQRPDHVTSQLRALNGVAAEAPVTGLNLHANAVFLDLPSPWLAIP
HLSRVLDTTKQAHICCFSPCIEQVARAVETLKKHGWKKIEMVEVSSKRWEGHKEMVKSVGDAVERLRDIKRRRVLGLRKR
NERIARERLQNKLKSEEDQETSVAASESTPAAEDDEEDENESSELKHKNESAQKYRGFNPWGKGQRIREGDERFEWLDVS
RVELEIKSHTSYLTFAILPPVMPANLVNSEGIILSSLPASTDL

GO term prediction

Biological Process

GO:0030488 tRNA methylation

Molecular Function

GO:0016429 tRNA (adenine-N1-)-methyltransferase activity

Cellular Component

GO:0031515 tRNA (m1A) methyltransferase complex