Protein

MCA_04776_1

Length
442 amino acids

Gene name: TRM61

Description: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61

Browser: contigC:3998197-3999526+

RNA-seq: read pairs 1460, FPKM 40.7, percentile rank 60.6% (100% = highest expression)

Protein function

Annotation:TRM61tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61
KEGG:K07442TRM61 tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]
EGGNOG:0PJ45TRM61Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA
SGD closest match:S000003661GCD14tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61
CGD closest match:CAL0000194641TRM61tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61

Protein alignments

%idAln lengthE-value
MIA_00476_158.74%4462e-174MIA_00476_1
A0A0J9XH32_GEOCN53.30%4241e-156tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Geotrichum candidum GN=BN980_GECA16s02155g PE=3 SV=1
UniRef50_A0A0J9XH3253.30%4243e-153tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 n=6 Tax=Ascomycota TaxID=4890 RepID=A0A0J9XH32_GEOCN
A0A1E3PFY5_9ASCO50.36%4193e-143tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_27029 PE=3 SV=1
A0A167FWG3_9ASCO49.39%4113e-142tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Sugiyamaella lignohabitans GN=GCD14 PE=3 SV=1
A0A060TD05_BLAAD48.89%4071e-141tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B20152g PE=3 SV=1
TRM61_CANAL46.31%4064e-125tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TRM61 PE=3 SV=1
TRM61_YEAST46.42%4056e-121tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GCD14 PE=1 SV=1
TRM61_YARLI43.24%4443e-117tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TRM61 PE=3 SV=1
A0A1E4TC21_9ASCO43.17%4101e-111tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32610 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0210

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 442

Detailed signature matches

  1. Family IPR014816
    tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14
    1. PF08704 (GCD14)
    2. PS51620 (SAM_TRM61)
  2. Domain IPR029063
    S-adenosyl-L-methionine-dependent methyltransferase
    1. SSF53335 (S-adenosy...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. mobidb-lite (disord...)

Protein sequence

>MCA_04776_1
MSFLEANNTIKDGDLILAWMNRSNIRPIFIKSGEVFHSQYGSFPHDKIIGKPFGSQIPGSTGRGFIHVIAPTPELWSLSL
RHRTQIVYTPDASYIVQRLGIRPGSRVIEAGTGSGSFTHALARTINKKGQLFTFEFHKPRYEEALIEITQHKLHQNTVIT
HRDVCQDGFLKPNIDNAMDPESVRKTLKPITKKNEKGEEEVILSLQASSVFLDLPSPWLAIPHLADVMDTAQQTSICCFS
PCMEQVTRTVETLKREGWRKIEMVEVSSKRWEGHKEMIRGVDDAVERLRDVKRRRIIGLRRRNNRIQKELENKKKGVQKQ
EEQDEDIVLEDVTVEEEDLSAGQEQRETTDNNTSNKSSSKIRGYNPWGKGMRIKEGDERFEWRDVSRVEYELKSHTSYLT
FAVHPPALPEGLVNEEQVVISSIPPPSTTTAEEKPAVANVEA

GO term prediction

Biological Process

GO:0030488 tRNA methylation

Molecular Function

GO:0016429 tRNA (adenine-N1-)-methyltransferase activity

Cellular Component

GO:0031515 tRNA (m1A) methyltransferase complex