MIA_00461_1

Protein

Length

1,584 amino acids

Protein function

EGGNOG:	0PG3H	PGUG_05698	Phospholipid-translocating P-type ATPase domain-containing protein
SGD closest match:	S000000968	DNF1	Phospholipid-transporting ATPase DNF1
CGD closest match:	CAL0000173967	orf19.932	Phospholipid-transporting ATPase

Protein alignments

	%id	Aln length
MCA_04330_1	71.647%	1372	MCA_04330_1
A0A0J9X7A2_GEOCN	67.248%	1319	Phospholipid-transporting ATPase OS=Geotrichum candidum GN=BN980_GECA04s03640g PE=3 SV=1
A0A060TDY5_BLAAD	59.677%	1364	Phospholipid-transporting ATPase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D11220g PE=3 SV=1
A0A167DMY9_9ASCO	58.862%	1388	Phospholipid-transporting ATPase OS=Sugiyamaella lignohabitans GN=DNF1 PE=3 SV=1
UniRef50_A0A0K8L7H0	55.373%	1340	Phospholipid-translocating ATPase n=1 Tax=Aspergillus udagawae TaxID=91492 RepID=A0A0K8L7H0_9EURO
Q6C5L2_YARLI	53.492%	1389	Phospholipid-transporting ATPase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E17105g PE=3 SV=2
A0A1E3PGA2_9ASCO	54.303%	1348	Phospholipid-transporting ATPase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83856 PE=3 SV=1
ATC5_YEAST	52.406%	1351	Phospholipid-transporting ATPase DNF1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DNF1 PE=1 SV=2
A0A1E4TDZ8_9ASCO	53.426%	1299	Phospholipid-transporting ATPase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_26222 PE=3 SV=1
A0A1D8PMY6_CANAL	51.642%	1309	Phospholipid-transporting ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.932 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0092

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily IV (IPR006539)

Domains and repeats

Domain
243 - 306
P-type ATPase, N-terminal (IPR032631)
1,229 - 1,478
P-type ATPase, C-terminal (IPR032630)
Domain
263 - 351
P-type ATPase, transmembrane domain (IPR023298)
626 - 749
P-type ATPase, transmembrane domain (IPR023298)
1,250 - 1,478
P-type ATPase, transmembrane domain (IPR023298)
Domain
478 - 536
P-type ATPase, A domain (IPR008250)
584 - 624
P-type ATPase, A domain (IPR008250)
749 - 1,249
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)

1 200 400 600 800 1000 1200 1400 1584

Detailed signature matches

IPR001757

P-type ATPase
1. TIGR01494
  
  1,169 - 1,282
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
IPR006539

P-type ATPase, subfamily IV
1. TIGR01652
  
  264 - 1,486
  
  TIGRFAMs
  TIGR01652 (TIGR01652)
IPR032631

P-type ATPase, N-terminal
1. PF16209 (PhoLip_ATP...)
  
  243 - 306
  
  Pfam
  PF16209 (PhoLip_ATPase_N)
IPR023298

P-type ATPase, transmembrane domain
1. SSF81665 (Calcium A...)
  
  263 - 351
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  1,250 - 1,478
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  626 - 749
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR008250

P-type ATPase, A domain
1. SSF81653 (Calcium A...)
  
  584 - 624
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
  
  478 - 536
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR023214

HAD-like domain
1. SSF56784 (HAD-like)
  
  1,033 - 1,091
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  1,144 - 1,249
  
  SUPERFAMILY
  SSF56784 (HAD-like)
2. G3DSA:3.40.50...
  
  1,042 - 1,243
  
  GENE3D
  G3DSA:3.40.50.1000 (G3DSA:3.40.50.1000)
IPR023299

P-type ATPase, cytoplasmic domain N
1. SSF81660 (Metal cat...)
  
  855 - 1,053
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
  
  761 - 777
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
2. G3DSA:3.40.11...
  
  749 - 1,041
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR032630

P-type ATPase, C-terminal
1. PF16212 (PhoLip_ATP...)
  
  1,229 - 1,478
  
  Pfam
  PF16212 (PhoLip_ATPase_C)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  757 - 763
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

334 - 638

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,470 - 1,584

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,314 - 1,342

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,403 - 1,408

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 291

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

712 - 1,260

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
Coil

396 - 416

COILS
Coil (Coil)

1,012 - 1,036

COILS
Coil (Coil)
G3DSA:2.70.15...

309 - 626

GENE3D
G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
NON_CYTOPLASM... (N...)

661 - 689

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,430 - 1,448

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

311 - 315

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,281 - 1,291

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,365 - 1,383

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF00122 (E1-E2_ATPase)

482 - 713

Pfam
PF00122 (E1-E2_ATPase)
PF13246 (Cation_ATPase)

875 - 965

Pfam
PF13246 (Cation_ATPase)
PR00119 (CATATPASE)

1,201 - 1,220

PRINTS
PR00119 (CATATPASE)

755 - 769

PRINTS
PR00119 (CATATPASE)
SFLDF00027 (p-type_...)

736 - 1,254

SFLD
SFLDF00027 (p-type_atpase)
SFLDG00002 (C1.7:_P...)

736 - 1,254

SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)
TMhelix

1,409 - 1,431

TMHMM
TMhelix (TMhelix)

315 - 329

TMHMM
TMhelix (TMhelix)

1,343 - 1,365

TMHMM
TMhelix (TMhelix)

1,261 - 1,280

TMHMM
TMhelix (TMhelix)

1,446 - 1,468

TMHMM
TMhelix (TMhelix)

639 - 661

TMHMM
TMhelix (TMhelix)

291 - 310

TMHMM
TMhelix (TMhelix)

1,295 - 1,313

TMHMM
TMhelix (TMhelix)

689 - 711

TMHMM
TMhelix (TMhelix)

1,380 - 1,402

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

1,292 - 1,313

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,343 - 1,364

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

316 - 333

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,409 - 1,429

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,384 - 1,402

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,261 - 1,280

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

292 - 310

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

639 - 660

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,449 - 1,469

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

690 - 711

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd02073 (P-type_ATP...)

266 - 1,361

CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)
mobidb-lite (disord...)

1 - 75

MobiDB Lite
mobidb-lite (disorder_prediction)

1,538 - 1,584

MobiDB Lite
mobidb-lite (disorder_prediction)

106 - 137

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

phosphorylation si...

757D

phosphorylation site
757D
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)
P-type ATPase sign...

757D

P-type ATPase signature motif
757D, 758K, 759T, 760G, 761T, 762L, 763T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

758K

P-type ATPase signature motif
757D, 758K, 759T, 760G, 761T, 762L, 763T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

759T

P-type ATPase signature motif
757D, 758K, 759T, 760G, 761T, 762L, 763T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

760G

P-type ATPase signature motif
757D, 758K, 759T, 760G, 761T, 762L, 763T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

761T

P-type ATPase signature motif
757D, 758K, 759T, 760G, 761T, 762L, 763T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

762L

P-type ATPase signature motif
757D, 758K, 759T, 760G, 761T, 762L, 763T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

763T

P-type ATPase signature motif
757D, 758K, 759T, 760G, 761T, 762L, 763T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)
putative ATP bindi...

757D

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

758K

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

759T

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

932F

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

956K

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

957G

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

958A

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

1,024D

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

1,071T

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

1,072G

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

1,073D

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

1,177R

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

1,180P

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

1,183K

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

1,203D

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

1,206N

putative ATP binding site
757D, 758K, 759T, 932F, 956K, 957G, 958A, 1,024D, 1,071T, 1,072G, 1,073D, 1,177R, 1,180P, 1,183K, 1,203D, 1,206N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)
SFLDF00027

757D

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDF00027 (p-type_atpase)

758K

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDF00027 (p-type_atpase)

759T

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDF00027 (p-type_atpase)

760G

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDF00027 (p-type_atpase)

761T

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDF00027 (p-type_atpase)

1,071T

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDF00027 (p-type_atpase)

1,183K

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDF00027 (p-type_atpase)

1,203D

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDF00027 (p-type_atpase)

1,207D

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDF00027 (p-type_atpase)
SFLDG00002

757D

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)

758K

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)

759T

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)

760G

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)

761T

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)

1,071T

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)

1,183K

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)

1,203D

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)

1,207D

SFLD_Res01
757D, 758K, 759T, 760G, 761T, 1,071T, 1,183K, 1,203D, 1,207D
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)

Protein sequence

>MIA_00461_1
MGSHHSPDQKRPSPDGQDLDGTPDHSFSYDSSFGDFNTGNISRSPLNPPTASNSTNFNAVSTGSPDQAASGPNHHAAFVP
LSDQQQQQQQQQLHFQEEATKVANTEATSNLHSSSYHNYSMNHHNEKANPPLPYTSPTAAALAAFPEIDRTRSRASEELR
HQNLINVQYDEQRLSEDGKQAPGHRKARIPTGKIKRNLSISARLHRTENSLRRISRRIPIVQQYVHKPDEDNAKEIEKER
SVYFNQPLPEHEKDPATGNISVEYPRNKIRTTKYTPLNFLPKNIYHQFHNIANIYFLFIVILGAFSIFGVENPGLAAVPI
IAIVAITAFKDAIEDYRRTVLDLEVNNTITHRLINIDNPNVEDDVISPWRKFKKGSTRVSVRFIRAIVRGFNNVFRKKAM
ERKRQLERNRSKSSLELDTVATRNTVYSQISNSIYDASLHGNSLDLNRYGATSKRALEKDGTVIDRSRSCPGKAAFKRAY
WKEISVGDVVKIYNNDEIPADVIILSTSDQDAACYIETRNLDGETNLKVRQGLNATKAIRHSRDLEQCVFQVDSEAPHLD
LYSYSGLLKWQQRENPLDLASPIVERAEAITISNMLLRGCTIRNTKWVIGVVVYTGNDTRIMKNSGITPTKRSRLTRELN
INVIINFLFVFILSFVSGVVNGCSFRSDHSSKHFFEFGSIGRNPPVNGIITFWAAVILLQNLIPISLYITIEIVKTFQAF
FIYSDCFMYYEPIDYPCTPKSWSISDDLGQIEYIFSDKTGTLTQNVMEFKKCTINGISYGKAFTEAMAGIMKREGTFTEQ
VAISKRQEIENDKEVMMAKLRAIYDSPEVFDNEVTFVSSKLVDHMQGQYGPEQSEAINHFLLVLALCHSVLPERTKDSAN
KLMYKAQSPDESALVNFARDMGYALLERTRNGVIISEQGQEHEYEVLHSLEFNSARKRMSVIVRMRKTGKIFLFCKGADN
IIYSRLAPGVQGELRQTTADELGEFAREGLRTLCLAEKEIPEKEYQIWAARHELASQALQNREDQMEQVADEIERDLYLI
GGTAIEDRLQEGVPETIELLSQAGIKLWVLTGDKVETAINIGYSCNLLDNGMELLLLQLNEKTVESANALLDSLLQSKFG
LMYSPEVMKAARNDHTVPSRQYAVVIDGESLDLVVSPDVKERFVLLCKQCRSVLCCRVSPSQKALVVAAVKTTLDVTTLS
IGDGANDVAMIQEADVGVGIAGLEGRQAVMSSDYGVGQFRFLGRLLLVHGRWAYRRLCEMIANMFYKNVVFTLTLFWYNF
NNSFDGSYLFDYTYITLFNLAFTSLPVIFMGFLDQDVTDKISMAVPALYRRGILRLEWNQLKFWIYMIDGLYQSAVCYWL
AFSMFYDGGFISPNGRQNNFREGYGALVATSAIIACNLYILINEYMWDWLFLLIVAISILLVFFWTGIYTLFTASRFFYK
AAPQIYGSLAFWAYLLLASIACLLPRWAAKCYQKMFMPRDIDIVREQWRVLGMFNHLRHEGDTEDMWATHSTTSTEENEM
PVLYHEGASDGTVVGGATRGPGNGMMMDEELGEVPSKKEKRHLNLPHRHHASESSSSDSGKVAV

GO term prediction

Biological Process

GO:0015914 phospholipid transport

Molecular Function

GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004012 phospholipid-translocating ATPase activity
GO:0005524 ATP binding

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features