Protein

MIA_00425_1

Length
708 amino acids

Browser: contig01:1207588-1209775-

Protein function

EGGNOG:0PHSNFG01789.1Ferric-chelate reductase
SGD closest match:S000005908FRE3Ferric reductase transmembrane component 3
CGD closest match:CAL0000185898CFL4Ferric/cupric-chelate reductase

Protein alignments

%idAln lengthE-value
MCA_05580_140.453%7072.16e-174MCA_05580_1
A0A0J9XL84_GEOCN36.812%6907.12e-154Similar to Saccharomyces cerevisiae YOR384W FRE5 Putative ferric reductase with similarity to Fre2p OS=Geotrichum candidum GN=BN980_GECA32s00846g PE=4 SV=1
UniRef50_A0A0J9XI2536.416%6921.05e-149Similar to Saccharomyces cerevisiae YOR384W FRE5 Putative ferric reductase with similarity to Fre2p n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XI25_GEOCN
Q6CET4_YARLI35.158%6037.42e-118YALI0B13134p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B13134g PE=4 SV=1
A0A060SVU5_BLAAD34.229%5587.93e-100ARAD1A00286p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A00286g PE=4 SV=1
A0A167FY66_9ASCO29.454%6965.33e-96Fre2p OS=Sugiyamaella lignohabitans GN=FRE2 PE=4 SV=1
A0A1E3PIN1_9ASCO28.167%6711.75e-82Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83263 PE=4 SV=1
FRE3_YEAST28.612%7131.12e-76Ferric reductase transmembrane component 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRE3 PE=1 SV=1
A0A1D8PN54_CANAL27.454%7034.87e-75Ferric/cupric-chelate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CFL4 PE=4 SV=1
A0A1E4TLJ4_9ASCO27.541%6107.48e-74Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30726 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7650
Predicted cleavage: 60

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 708

Detailed signature matches

  1. Domain IPR013130
    Ferric reductase transmembrane component-like domain
    1. PF01794 (Ferric_reduct)
  2. Domain IPR017927
    Ferredoxin reductase-type FAD-binding domain
    1. PS51384 (FAD_FR)
  3. Domain IPR013112
    FAD-binding 8
    1. PF08022 (FAD_binding_8)
  4. Domain IPR013121
    Ferric reductase, NAD binding domain
    1. PF08030 (NAD_binding_6)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:2.40.30.10
  3. G3DSA:3.40.50.80
  4. NON_CYTOPLASM... (N...)
  5. SFLDG01168 (Ferric_...)
  6. SFLDS00052 (Ferric_...)
  7. SIGNAL_PEPTIDE (Sig...)
  8. SIGNAL_PEPTID... (S...)
  9. SIGNAL_PEPTID... (S...)
  10. SIGNAL_PEPTID... (S...)
  11. SSF52343 (Ferredoxi...)
  12. SignalP-noTM
  13. TMhelix
  14. TRANSMEMBRANE (Tran...)
  15. cd06186 (NOX_Duox_l...)
  16. mobidb-lite (disord...)

Residue annotation

  1. FAD binding pocket...
  2. FAD binding motif ...
  3. beta-alpha-beta st...
  4. NAD pyrophosphate ...
  5. NAD binding pocket...
  6. NADP ribose bindin...

Protein sequence

>MIA_00425_1
MKFQNIAISAFLANAALAANGVTFLQSACNTLTNSYTWECPSQYVSKTSSAQTGKKSRGKSTDTTCNCWSPEYLTSYVSC
ALRASNKKGEAVVKLLLATCSASTIRPTLTYDELMEIYENGTDYFVDVNELSTSKTVYSPIFFNQSSIDINVRSYRASSY
SSYSGKLYGGLMLAYFAAVMAVATVFNFFKTVTPGFSKKMANTKPFVIVRQKFANPAMFGFKNGLAFKWGPYNIVNMSIP
TRTQSWVIIGYVVMFIILMFIRYDVFEENTRYTSKRAQLSKYVTDRSGEITIFQMPLLYLFASRNNIAMIFTGWSYDTMN
AYHRWIARVTVIAVLIHSVAYTDVYILRGAASLHSTWKKSWMIWGIVGTICGCLLCFFSLRHFREKFYEFFLYTHMVLVA
FFTIGTWYHLKHTHADPEWIYATVAVWAFDRAFRLIRIFLNGLHASAEVELVNSDFIKTTVSYLHWWTPGPGHYVFINWL
FPIWRCWENHPFTIYQSPVPGEEKKFIIMTKIEKGKTKQLGEYLAKKGGKVKMPVLIDGPYGHTFPISGSETIVLMAGGI
GFTGAYSYVNKLKPQAEKKHIVFFWCVRTHEQANLFKNEIEFMNRSGIDVQLYISDESESSEGSISEKRESGSDAEKTSL
SSTSSSTVHYGVPNIPSLVENYVTEAPGSIGFFICGPPGLNDAVRANVSKNMHKGKGAVEVFVEGFSW

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.