Protein

MIA_00424_1

Length
702 amino acids

Browser: contig01:1204690-1206856-

Protein function

EGGNOG:0PHSNFG01789.1Ferric-chelate reductase
SGD closest match:S000005908FRE3Ferric reductase transmembrane component 3
CGD closest match:CAL0000191531CFL2Cfl2p

Protein alignments

%idAln lengthE-value
MCA_05581_139.577%7108.71e-164MCA_05581_1
A0A0J9XI25_GEOCN37.555%6877.25e-149Similar to Saccharomyces cerevisiae YOR384W FRE5 Putative ferric reductase with similarity to Fre2p OS=Geotrichum candidum GN=BN980_GECA16s00164g PE=4 SV=1
UniRef50_A0A0J9XI2537.555%6871.48e-145Similar to Saccharomyces cerevisiae YOR384W FRE5 Putative ferric reductase with similarity to Fre2p n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XI25_GEOCN
Q6CF26_YARLI32.847%6853.19e-119YALI0B10846p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B10846g PE=4 SV=1
A0A1E3PIN1_9ASCO29.068%7196.69e-90Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83263 PE=4 SV=1
A0A167FY66_9ASCO29.513%6982.98e-89Fre2p OS=Sugiyamaella lignohabitans GN=FRE2 PE=4 SV=1
A0A060SWW8_BLAAD30.729%5761.45e-85ARAD1A00264p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A00264g PE=4 SV=1
A0A1E4TLJ4_9ASCO29.210%6714.79e-78Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30726 PE=4 SV=1
A0A1D8PME3_CANAL28.689%6102.19e-74Cfl2p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CFL2 PE=4 SV=1
FRE3_YEAST27.451%7141.25e-71Ferric reductase transmembrane component 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRE3 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0752

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 702

Detailed signature matches

  1. Domain IPR013130
    Ferric reductase transmembrane component-like domain
    1. PF01794 (Ferric_reduct)
  2. Domain IPR017938
    Riboflavin synthase-like beta-barrel
    1. SSF63380 (Riboflavi...)
  3. Domain IPR017927
    Ferredoxin reductase-type FAD-binding domain
    1. PS51384 (FAD_FR)
  4. Domain IPR013112
    FAD-binding 8
    1. PF08022 (FAD_binding_8)
  5. Domain IPR013121
    Ferric reductase, NAD binding domain
    1. PF08030 (NAD_binding_6)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:2.40.30.10
  3. G3DSA:3.40.50.80
  4. NON_CYTOPLASM... (N...)
  5. SFLDG01168 (Ferric_...)
  6. SFLDS00052 (Ferric_...)
  7. SSF52343 (Ferredoxi...)
  8. TMhelix
  9. TRANSMEMBRANE (Tran...)
  10. cd06186 (NOX_Duox_l...)
  11. mobidb-lite (disord...)

Residue annotation

  1. FAD binding pocket...
  2. FAD binding motif ...
  3. beta-alpha-beta st...
  4. NAD pyrophosphate ...
  5. NAD binding pocket...
  6. NADP ribose bindin...

Protein sequence

>MIA_00424_1
MGPGYSSKMSSGKITEVVSACNCNSPEFLASFVDCITRASLNQNDLYKAMRIMPEKCKKYNPNLSIYTLDKIYANATDNN
YFINVGSSQQVAQAKKNINYNPIKLSNEFIVKVRRSYSSGYYVKYTGLLYGGLLNAYFGGILVAGTVANFLRKSLPVFFM
RSTNTKQALWLRQKLTNPALFGYKHNMPVKFGWLVNMSLPTRAQFWVLAGYFCMVIIFMFIRYDLFDGNIRLQSRSRQLS
FYVAYRSGIMAVAHLPLVVTFAGRNNIWSWLTGWSFDTLNIYHRWLARVMYTLAFIHSIGFTVFYHLGHKYTQEFHHGFF
RWGAVAITSGGIVLFFSLRHFREHVYDVFLAIHWVFVSIFFAGVWWHLDDLHNKEWIYTSIALWAFDRFMRLVRIAFSSI
NSVADFEIYKSPQLIKLKIAYSNFWEPQPGNYVFIHFVDPIWSIIHNHPFSCYPSPRTDEEDKLILCMKVRNGKTKRLAQ
YLSQKLQPRQKVRILLDGPYGHTFPLTNNQTIILLAGGIGITAIYSYACRLLDQAEKKHIIMIWVIQDTEILDVFDNEIT
FLKQKHSIDINIYVTKEKRLDNPSLDSAQTNEKTKLDNPDSPTDYFIEPHGPEYSSVDQQEVTHINYSSRHKLITKHREH
TISLYRPKIDNLVETLITESPGTIAFLACGPPRFNDDVRKAVTDQMGKGNGRIDLFLESYNW

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.