Protein

MIA_00395_1

Length
1,790 amino acids

Browser: contig01:1126495-1132049-

Protein function

EGGNOG:0PJ0GPGUG_02145nucleotide exchange factor
SGD closest match:S000004417TUS1Rho1 guanine nucleotide exchange factor TUS1
CGD closest match:CAL0000189010TUS1Rho family guanine nucleotide exchange factor

Protein alignments

%idAln lengthE-value
MCA_01829_147.65%14250.0MCA_01829_1
A0A0J9XFT2_GEOCN41.46%11820.0Similar to Saccharomyces cerevisiae YLR425W TUS1 Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway OS=Geotrichum candidum GN=BN980_GECA15s00659g PE=4 SV=1
UniRef50_A0A0J9XFT241.46%11820.0Similar to Saccharomyces cerevisiae YLR425W TUS1 Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XFT2_GEOCN
A0A060TFX0_BLAAD35.07%11920.0ARAD1D26444p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D26444g PE=4 SV=1
Q6C661_YARLI29.33%10676e-115YALI0E12155p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E12155g PE=4 SV=1
A0A167CRN4_9ASCO28.09%7377e-70Rho family guanine nucleotide exchange factor ROM2 OS=Sugiyamaella lignohabitans GN=ROM2 PE=4 SV=1
A0A1E3PFC6_9ASCO40.36%2809e-55Dbl homology domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84112 PE=4 SV=1
A0A1D8PDA9_CANAL22.39%11033e-44Rho family guanine nucleotide exchange factor OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TUS1 PE=4 SV=1
A0A1E4TD89_9ASCO26.40%5341e-39Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_46140 PE=4 SV=1
TUS1_YEAST20.54%8184e-26Rho1 guanine nucleotide exchange factor TUS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TUS1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0395
Predicted cleavage: 13

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1200 1400 1600 1790

Detailed signature matches

  1. Domain IPR000219
    Dbl homology (DH) domain
    1. SSF48065 (DBL homol...)
    2. PS50010 (DH_2)
    3. PF00621 (RhoGEF)
    4. SM00325 (RhoGEF_3)
  2. Domain IPR011993
    PH domain-like
    1. G3DSA:2.30.29.30
    2. SSF50729 (PH domain...)
  3. Domain IPR001849
    Pleckstrin homology domain
    1. PS50003 (PH_DOMAIN)
    2. SM00233 (PH_update)
  4. Domain IPR001180
    Citron homology (CNH) domain
    1. PF00780 (CNH)
    2. PS50219 (CNH)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.20.90...
  2. PF15405 (PH_5)
  3. cd00160 (RhoGEF)
  4. mobidb-lite (disord...)

Residue annotation

  1. GTPase interaction...

Protein sequence

>MIA_00395_1
MYPYNNSSPPRDSGYIPSSNNNAIQTSYETYQQQQEQLYQQQLYFQQQYQHSNPQQAPPPLPPKENSQRSYRYSNGSPLV
NMHYADSASPTRPYTELPRTVSPISRSNVLPDPFIETAGAPNSENANPPDLPPKPTQYKTIIQSSDNGYSYKLPHSASPI
YFYGTQNTIDLAQTNINNTTTAYISHYQATSATDYNQQQQQQQQYAQEHQYYQYASNTAHFSKYSSAPLTPTNPLSSSPN
RSSPITASGSSSIYVQNTSPTRFPISLRVDTTTRSGSPTKQFGSSSSSQQSTPLDRKPLGPRLPPSSFSSSTVFSTASSA
AQRSAPSPRDPPQTPSRPTHRHSLSHSGSKSTGSSSGHSHSNSLANLYSHLPTGSSPTSYSDASIIDDPYRYQSFDHCSI
ISGPFVPTSPLSLIKRKDVATSPTHTHSKSAGSLSNSTVPTIATKPKLDRHKSTESNGEVDALNSSGHSGKSAFSNCSNI
SSYSSSSYSPQHVYPPPDAFQSGQKSLAYPIDETTLPYPVSPVPSSPPKPVTSRQDIIESFANFSLKSGQSGAFVDSIST
TSRDTVKGPEMFRMHRSQTCTDMMDDQHELLPPPTRSYSTISKSTPISKSSMRSSQISAATDYSLMLKLDLPSIPDSRTR
LDPDKLSSRDFDLCKTPWAVSSICIWIEYLNTIAEMSFETLSEALINLFRHTVPTLGWVAAERITVPLLESLTNCAFLTV
NEETGVLVVNPYHAISGVLPSITGKGCYSSKSHQLDKTARNNEVYRCYSSRCSRTIPHKPVLPTINMAQKFNDSDRVNWA
KIWNLSDDDLSKLEKKVIERQCAIQELIGTEEIYVRGLKAFLNVYGDYLNRAKPPVVSNQARFWNDTFGCIQGLIDSNDN
QLLTYLKIRQAQQGPFIQSIADLVLNWLKAARAPYLQRASTYSYAMRVVSSEKSKKNELFAAWLDKAERDPRLTRVQKFD
FLMSSPFMRLCRYNLLFDRIRASTPTDDPEYQLWGRCIDECRVIVEEYNRIHGESEDISSIMTLEERITFPNLEEKVDLR
LRDSRRKIYYEGDVLRKGEFGIDYVDTHMILLDNYLVLAKVKKDNLEKYMVTKRPIPLELLVIEQADGEPVIKSSTKMIT
GVLSGGSHESKKQSKNSNSGNGSSANGNGSNSGAGTPAGSGSAGATYDNENIIYPIKVRDLGATGNHASKAVYYLYTQTE
EERRAWVSKMLLAKRDYSSAAFAQNSEPFRIRVVEDRFFSYENGEAPKLAVYAEATALDRGICEYEAANGSTRVGTLTTA
TSRINCGVTCSLGGKYFMVVGIENGIYACDMSIKKVPSTEVPKRSQSSSPYKGSKPLATVPETETSNGEKNDETATWMAP
QWVKVLDLQKTTQLEILTDYNVLIVLSDRTLAYYPLDQILAIVMNNNRKPRDPNLAGYSISRPKEVTFFATGYMSSGGPG
MTADSKRQLLFYNIKKRGPKDPREAIKKNGGSMTVEVVEPVKERGSQKKRSHFIVNKSNENARGDRLEEPGVATRSGSIP
NRAGISNASTEYFREYDSVTLSGEVFGMTLFGSTFFTHTGRGFEVLALSYKIPRLVPDAASINHALNRSSTSPQTLGDTV
RRKIENSKPIGAFMINDNCILLVYEQIGIFIDKFGEMSSPIVINLLARAKSALVSYPYLLIFSDELIEVRKMDVGSAAAH
GAAASRKIRNAAAAAVDPKVKKNLKSDNEPLESQFTRANLQGSDYSSCELKQVITGKHIRLVVDGSKRSKQGQEIMVSMA
HPKYSNQQLLVELVPNEFVVEDDNSSLLGL

GO term prediction

Biological Process

GO:0035023 regulation of Rho protein signal transduction

Molecular Function

GO:0005089 Rho guanyl-nucleotide exchange factor activity

Cellular Component

None predicted.