Protein

MCA_01829_1

Length
1,943 amino acids

Browser: contigA:5599594-5605498-

RNA-seq: read pairs 1634, FPKM 10.4, percentile rank 26.5% (100% = highest expression)

Protein function

EGGNOG:0PJ0GPGUG_02145nucleotide exchange factor
SGD closest match:S000004417TUS1Rho1 guanine nucleotide exchange factor TUS1
CGD closest match:CAL0000177920ROM2Rho family guanine nucleotide exchange factor

Protein alignments

%idAln lengthE-value
MIA_00395_147.72%14250.0MIA_00395_1
A0A060TFX0_BLAAD30.75%12134e-168ARAD1D26444p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D26444g PE=4 SV=1
UniRef50_A0A060TFX030.75%12139e-165ARAD1D26444p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060TFX0_BLAAD
A0A0J9XFT2_GEOCN47.46%5522e-149Similar to Saccharomyces cerevisiae YLR425W TUS1 Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway OS=Geotrichum candidum GN=BN980_GECA15s00659g PE=4 SV=1
Q6C661_YARLI27.40%10227e-96YALI0E12155p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E12155g PE=4 SV=1
A0A167CRN4_9ASCO30.06%6822e-64Rho family guanine nucleotide exchange factor ROM2 OS=Sugiyamaella lignohabitans GN=ROM2 PE=4 SV=1
A0A1E3PFC6_9ASCO32.40%3211e-46Dbl homology domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84112 PE=4 SV=1
A0A1E4TD89_9ASCO24.47%6132e-32Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_46140 PE=4 SV=1
TUS1_YEAST19.38%7381e-23Rho1 guanine nucleotide exchange factor TUS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TUS1 PE=1 SV=1
Q5AH90_CANAL29.00%3319e-22Rho family guanine nucleotide exchange factor OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ROM2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3484
Predicted cleavage: 11

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1200 1400 1600 1800 1943

Detailed signature matches

  1. Domain IPR000219
    Dbl homology (DH) domain
    1. SSF48065 (DBL homol...)
    2. PS50010 (DH_2)
    3. PF00621 (RhoGEF)
    4. SM00325 (RhoGEF_3)
  2. Domain IPR011993
    PH domain-like
    1. G3DSA:2.30.29.30
    2. SSF50729 (PH domain...)
  3. Domain IPR001849
    Pleckstrin homology domain
    1. PS50003 (PH_DOMAIN)
    2. SM00233 (PH_update)
  4. Domain IPR001180
    Citron homology (CNH) domain
    1. PS50219 (CNH)
    2. PF00780 (CNH)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.20.90...
  3. cd00160 (RhoGEF)
  4. mobidb-lite (disord...)

Residue annotation

  1. GTPase interaction...

Protein sequence

>MCA_01829_1
MPSYSSIYRDSTENATPSKYTYKPLQVQSNINGYGFRLPPSTAPSLQKAAMAISTPSHVEALAIHSPPTSPETEIKNIKY
YQQSNKYDTSYTDFDSRTYQKNFENSTSAMMYRINPNARHRMDVPMASKNTNQKDPSYFFYDEYLPNSGPTLRPDTQTSA
SRMYRSDFGTNVKSPTSSKSPRSSERRPLGPRLPPSNAGFMLPKTTSNISAPANVLQQSPNVYESHSKSSHHQNTNNKVM
LRTPVSLLPASPLSQENFKFNNSLLPNLPDYSSTSKYQELTYEENDIQLFDMKKKQLTVSTQEELGSPYDYQLRPKPQKI
QTTDLLLDQLPLEQDVLNSSGHSGNSAFSACSGLSSYTSASPIVPYASDDLVPSPINNSGASGSCFTNYYSTQAEPITPP
PHAPIPGKSSYGYGNAGYTTGKSSNLGPPQYDINNGGNSTLNNPLSCLNDNNNAVLDLPALDTSQPPSLPIHNNKKEPST
MNKVSYTNSATNFTKAPSPYSTENFGSNIPAYIDSPLSRDSNLKPSQGVSLQNNIANSTDLSPNKKFEDHLSISKIHRSQ
TFSDITADDLLLPPPTRSYTTSSFMSKLSSSGTGDAGSFTDSFRSSSYSTKTDDDSLMLRLGLPSSIPDSHAQLDPTVLS
SRDFNKCPQPWFVSKICQWIIQLNQQHEMTTETLSEALIALFRHYIQTLGWVASERITVPLMEGLMNAGFLSIDKESGVL
IVDPACATSGILPTITGYGCYSLKIHSNITQQTTTSAIPATSTTSTGGSNDTKKMGKSLESCRCYSPRCLRTIPYKAVLP
QLDKAQQLNDSDRMNWAKIWNITDSDLAKLDKRVIERQCAIQELIGTEELYVRNLKAFLSVYGERLNKAKPPIVPNQKKF
WEDTFGCIPGLIESNDNQFLTHLKVRQIQQGPFIECIADLILNWLKGAKQPYLSRATTYSYAMRVVTNEKAKKNELFLNW
LEDVERDSKLNRQQKFDFLIASPFTRLCRYNLLFERIKATTLPDTQEHRLLSRCIDECKQIVTEYNRIHGEAEDLSSIIM
LEERIIFPNPEQRVDLRLADSRRRRKILYQGDVLRRGEYGIDYIDTHMILLDNYLILAKITKNTTNGNNSSSSSLGSANL
NGFGSSNSSGANGSFANSRNNPTAKYLVTKKPIAMELLVIEQADGEPVAKSNTKMITGVLSGNTAEAGRRLSKIYNAASS
PSSESSANGGNTFRTNSNISLNGTGANGKTSPNSPVVTVLNSNNENENIIFPIKIRDLGQNKKTYVIYTQTEDERKNWVN
KILAAKREYSSAVYAYNAEPFKLRVIETGFFNYESLSESPKIPLFTEANPMDRALRDYETVNSSSKNTSLMLNTKAGNSG
STLNKTGFANNNTTNNAPVDQKKCAQSRINCVVTCNHGGKLFFVVGTDNGIYACDMTIKKASKQQQERKKGRKPVNARNE
RNGTSNHPVEDELNQVGSAAWASSGWIKCLNIIKVTQMEVLTDYNLLIVLTDKTLVYYHLDQFLSIVMNAYHKPRDNHMA
GYAISSRNRDVTYFATGYMTSGMNEKRELLFYKCKDPKDTLKKSSLIEILEPVKERGTQKKRSHFVVAGAGRANSNNSNY
SATSTNTMESVISIDRSETSHSSTEYFKSYDQVYIPQDSYGITLLSSTFFVHCAKGFQLLSLNFIKYQPKLVPEPSSIPL
VMHRGFITSSNYPYHSSPSSYIHQSNSASSPIGSSLPIGKNEIKSSSTSAITSSSTADAFKRKLESSKPIASFMINDNTI
LLVYDQLAIFVDKYGQLSSPLHANLLCKINSAIVSYPYLITFSDELIEIRRIDFPTGTTTTPNFSSMGSSTINGKVGSGG
KPANGTYQPTSPLNISPKKPIGQASPLSSAAKSRARSDSPHHTCFQLKQVITGKDIRLVDGQRDYRQIIVAMAHPKIRGQ
QIMVELIGNEFVVDDDNSSLLGL

GO term prediction

Biological Process

GO:0035023 regulation of Rho protein signal transduction

Molecular Function

GO:0005089 Rho guanyl-nucleotide exchange factor activity

Cellular Component

None predicted.