Protein

MIA_00394_1

Length
1,774 amino acids

Browser: contig01:1120483-1125950-

Protein function

EGGNOG:0PJ0GPGUG_02145nucleotide exchange factor
SGD closest match:S000004417TUS1Rho1 guanine nucleotide exchange factor TUS1
CGD closest match:CAL0000177920ROM2Rho family guanine nucleotide exchange factor

Protein alignments

%idAln lengthE-value
MCA_01839_136.815%5846.62e-91MCA_01839_1
A0A0J9XGJ0_GEOCN27.022%5811.35e-48Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA15s00648g PE=4 SV=1
UniRef50_A0A0J9XGJ027.022%5812.77e-45Uncharacterized protein n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XGJ0_GEOCN
A0A060TFX0_BLAAD23.497%3661.93e-22ARAD1D26444p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D26444g PE=4 SV=1
A0A167CRN4_9ASCO23.904%5021.17e-13Rho family guanine nucleotide exchange factor ROM2 OS=Sugiyamaella lignohabitans GN=ROM2 PE=4 SV=1
Q6C661_YARLI20.120%3333.19e-13YALI0E12155p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E12155g PE=4 SV=1
A0A1E4TD89_9ASCO20.690%3488.31e-12Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_46140 PE=4 SV=1
TUS1_YEAST21.351%3701.07e-09Rho1 guanine nucleotide exchange factor TUS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TUS1 PE=1 SV=1
Q5AH90_CANAL22.126%3481.75e-09Rho family guanine nucleotide exchange factor OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ROM2 PE=4 SV=1
A0A1E3PFC6_9ASCO23.052%3082.98e-08Dbl homology domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84112 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0019

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1200 1400 1600 1774

Detailed signature matches

  1. Domain IPR000219
    Dbl homology (DH) domain
    1. SSF48065 (DBL homol...)
    2. PS50010 (DH_2)
    3. PF00621 (RhoGEF)
  2. Domain IPR001180
    Citron homology (CNH) domain
    1. PS50219 (CNH)
    2. PF00780 (CNH)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.20.90...
  2. mobidb-lite (disord...)

Protein sequence

>MIA_00394_1
MSYPSQHTQEPQSDEKNDRRWSAFESLNTSNSLNNSPPNSSFSNTTAPVPPVNPFKKTTSATIDQDPGSDLVQHASQQKA
NNFQNLHTMFPVPFSDLNSPESADGLQNAHLSNPDSVPSLLPKLQIDTNPIPSVAPLFSAKKPSSTLLENDTKPDLPKLQ
LQDSQLPRSPQQTAASSTATAKSPFHIPRKPIDHKFIVKDHAKRHSISGSIVQPNFDLAPTPPQPQFYAPQPPTSQDYKN
GIRQEQQTQPVFGMPPSSPTQHADSVTTHSVSYPGGPILSSGLQTQSEPEPNSNNNANYLKIVYGQEQQLPQHPPDPARL
NSRVSISRRYSRIANYNRHDASCNSLPDVQASEIDQIEKLLRRHSLLSSQASSTVSVPSQMTHNQQTNTRFSGLNVPTSL
ENRRRSWAPSSSTPFLNEKFQNCAGADEKLHDQVFDAEKLDVSDFDHSNSNSGEGQQSSPFFAVSSSSPTTPTPGTINTG
LSSNIPLISVDSTRTETSSRPLSLVIPSGNNNSSSNSTTPTASSTLSPTEMSNSPFNFRNGLNTEGVPSTTNSITQETPV
VSPTNISTQSFIPPIPKITHNYMTSSSINPALQRAPSAPEAAVSSAARRHYPLTDQLSPPHNLNLAHRRIPSNSNPGIGR
AASTSATSTLLNNNPVPPLPITQNNSPSARPNTSDAALESSLSRNSSITSSNADQTFGAPWDSNDAKIELHDISVKQNSG
AWHEYWNIPIERINEFNEYDVQYQSELHSFIQQEENYVNGLHVFLDVFCDDKLADTISSSSMRKKFVDTLFEPLKKIVAI
NNQYLLMPFIKQQMTHKHTTPEQPNPNPFLDFLVPNVIEWLDNVKAPFLVFAKEFPLADSITKEQMETNEKFTSFLNAAN
EKARTHSGKDFSSLMHSTRIRFGLYKSHFQRLAKLLTKKQGCDDCDHEQLLKDKKTIEGLNLCVAKIDVLMKELNEIQRH
EESRLLMQRYEQIFKFKYPEDQILLNFSNHTQIAEKQAYRKKKNSSWDTHLITVILLDHFLFLVRKISYNEWQVLERPIH
MDLLRLENLDDPPIYKNTGAAVIAAVRRQPTHAPSAHIPRSSRPTSLSQHTPSQHKPSVSSISSTSTNSSTVNQNQSLTP
VQTHTTQGNIHSPVLNGSENSVPLTPSTPSFKSTGSTSSLTSSPTNSSMSSPTTTTSSVQFSDISSPSSSFPTPSTPKNP
VAAHAMVVDLAPKQNDKLIYPVRIRNIENDHKCRIAFDRQLDRKNFIDLLLDTKRKYAESQLNHHKVPLGLKVLDQSSFP
FTDISETLPSTVYTYGDVVDVALEEAGKFTGCTPVKGTGTNGLINVNCALHYSFSGEDVIFVGTSLGLYYARLIKSSNGK
LEQLNWKISVQLPNVTHIEVCQPALFILSSNRLVYLKLNEILVDLLSPKNRLTQTVISQPVTVSDSVECFHTGVLGGEKY
LFYANKSTKGLEKTDVFVYAVTTTGSRESQRKGFSRLFKGHESPFAEVLQKPTLIAHELFSPTKIHGFSFFGSYFFFLTT
NSFDHLKLNVRNPTPLPRADTVSNVLHNAGFSDAAISDFKTQLQNARTISVSFMHWDRRPSQGQPSSARSNSAVSVNDES
RNSSSSGLNTAPPTNNQPNLIHCFHKFAVMSVRNGDLYVPPGHGAGSAGSGMGACKPFRIQYLHKAESAYLWYPYLLLFS
PQLIEVRLVTAHNLSQSLVQVITGRNIKLLTCDRSSQPPVHGGSHSHGSPRIIISMAHPDPSIHTTVIMEIVRNHGVSSN
EKNLRGSLFDIGQY

GO term prediction

Biological Process

GO:0035023 regulation of Rho protein signal transduction

Molecular Function

GO:0005089 Rho guanyl-nucleotide exchange factor activity

Cellular Component

None predicted.