Protein

MIA_00379_1

Length
525 amino acids

Browser: contig01:1086854-1088432+

Protein function

EGGNOG:0PN8WCTSDaspartic-type endopeptidase CTSD
SGD closest match:S000006075PEP4Saccharopepsin
CGD closest match:CAL0000197684APR1Proteinase A

Protein alignments

%idAln lengthE-value
A0A0J9XEH7_GEOCN46.97%3471e-95Similar to Saccharomyces cerevisiae YPL154C PEP4 Vacuolar aspartyl protease (Proteinase A) OS=Geotrichum candidum GN=BN980_GECA13s00285g PE=3 SV=1
UniRef50_A0A0J9XEH746.97%3473e-92Similar to Saccharomyces cerevisiae YPL154C PEP4 Vacuolar aspartyl protease (Proteinase A) n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XEH7_GEOCN
A0A1E3PDR7_9ASCO38.66%4196e-84Acid protease OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84204 PE=3 SV=1
A0A167DHX2_9ASCO41.18%3232e-77Proteinase A OS=Sugiyamaella lignohabitans GN=PEP4 PE=3 SV=1
Q6CAK4_YARLI40.13%3192e-73YALI0D02024p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D02024g PE=3 SV=1
A0A060TC80_BLAAD39.34%3331e-71ARAD1B21318p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B21318g PE=3 SV=1
A0A1E4TI13_9ASCO30.06%3363e-33Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_123212 PE=3 SV=1
CARP_YEAST28.80%3165e-27Saccharopepsin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PEP4 PE=1 SV=1
Q59U59_CANAL28.11%3383e-25Proteinase A OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=APR1 PE=3 SV=1
MCA_05364_129.04%3349e-24MCA_05364_1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8492
Predicted cleavage: 54

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 500 525

Detailed signature matches

  1. Family IPR001461
    Aspartic peptidase A1 family
    1. PR00792 (PEPSIN)
  2. Domain IPR021109
    Aspartic peptidase domain
    1. G3DSA:2.40.70.10
    2. SSF50630 (Acid prot...)
  3. Domain IPR033121
    Peptidase family A1 domain
    1. PS51767 (PEPTIDASE_A1)
    2. PF00026 (Asp)
  4. Domain IPR034164
    Pepsin-like domain
    1. cd05471 (pepsin_like)
  5. SITE IPR001969
    Aspartic peptidase, active site
    1. PS00141 (ASP_PROTEASE)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SignalP-noTM
  8. TRANSMEMBRANE (Tran...)

Residue annotation

  1. catalytic residue ...
  2. catalytic motif cd...
  3. inhibitor binding ...
  4. Active site flap c...

Protein sequence

>MIA_00379_1
MNLFWTLATIVASVAASVNIGTTRTFPIKALDSSGTSNSQKFRRSISPLDPETLVSVQELMFSNSGDPKLRFLGAHAVGA
DTATTDGSTSLVTRHPWKELSRHVSKRNSDSGSLSSTTEISYYNSSSSSAISYYVEIKLGTFNDSADEKVYNVLIDTGSF
FTWVHSANCTTAECSEHTLFDAEQSTTSSFTGLPFYVIYTTGLINGTFIQDRVRLAGFDFGNQYFGLVTSGQSSFSSYAV
DGILGLPSKDPDSSTRGILNTLYEESLISQRIIGISLGGDEGNTTDNNEGSLSIGGVDSEKYSGEIEYYSIDNSSVFWEI
PVSGTFANGTEISFASGTSDNGTRTAIVDTGTTLLLMPPNDALKIHSYIENSITDGSNYVIPCNATIEFAFSFGTNGTLA
RNWSVGPYAYIGEQYNDDGLCLSNIQGLSVDGNQWVLGDVFLRGIYSVFDMDNAAVGFATKKASNTSVTPESTFVSLSSN
STSEASSSVSSSASATTTTKATSGASRVYMGVYTLALSFILQFLL

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004190 aspartic-type endopeptidase activity

Cellular Component

None predicted.