Protein

MIA_00377_1

Length
1,105 amino acids

Browser: contig01:1081208-1084631-

Protein function

EGGNOG:0PGECPOL3DNA Polymerase
SGD closest match:S000002260POL3DNA polymerase delta catalytic subunit

Protein alignments

%idAln lengthE-value
MCA_03146_175.274%10960.0MCA_03146_1
A0A0J9XGP4_GEOCN70.175%10830.0DNA polymerase OS=Geotrichum candidum GN=BN980_GECA16s02067g PE=3 SV=1
A0A060T781_BLAAD68.027%10540.0DNA polymerase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B21362g PE=3 SV=1
A0A1E3PEB0_9ASCO66.697%10870.0DNA polymerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_62083 PE=3 SV=1
Q6CHI6_YARLI64.463%10890.0DNA polymerase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A08426g PE=3 SV=1
A0A1D8PR64_CANAL65.738%10770.0DNA polymerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=POL3 PE=3 SV=1
UniRef50_P4658865.738%10770.0DNA polymerase delta catalytic subunit n=119 Tax=Eukaryota TaxID=2759 RepID=DPOD_CANAX
A0A167DI13_9ASCO70.699%9590.0DNA polymerase OS=Sugiyamaella lignohabitans GN=POL3 PE=3 SV=1
A0A1E4TLF2_9ASCO59.158%10920.0DNA polymerase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_89320 PE=3 SV=1
DPOD_YEAST56.852%10800.0DNA polymerase delta catalytic subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=POL3 PE=1 SV=4

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8117
Predicted cleavage: 28

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1105

Detailed signature matches

  1. Family IPR006172
    DNA-directed DNA polymerase, family B
    1. PR00106 (DNAPOLB)
    2. SM00486 (polmehr3)
  2. Domain IPR012337
    Ribonuclease H-like domain
    1. SSF53098 (Ribonucle...)
    2. G3DSA:3.30.42...
  3. Domain IPR006133
    DNA-directed DNA polymerase, family B, exonuclease domain
    1. PF03104 (DNA_pol_B_...)
  4. Domain IPR006134
    DNA-directed DNA polymerase, family B, multifunctional domain
    1. PF00136 (DNA_pol_B)
  5. Domain IPR023211
    DNA polymerase, palm domain
    1. G3DSA:3.90.16...
  6. Domain IPR025687
    C4-type zinc-finger of DNA polymerase delta
    1. PF14260 (zf-C4pol)
  7. SITE IPR017964
    DNA-directed DNA polymerase, family B, conserved site
    1. PS00116 (DNA_POLYME...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.34...
  2. SSF56672 (DNA/RNA p...)
  3. TIGR00592
  4. cd05533 (POLBc_delta)
  5. cd05777 (DNA_polB_d...)
  6. mobidb-lite (disord...)

Residue annotation

  1. active site cd05777
  2. catalytic site cd0...
  3. substrate binding ...
  4. active site cd05533
  5. metal-binding site...

Protein sequence

>MIA_00377_1
MSVLAKPATAVKRGHFTPASQSNNKRSKVSEPSSFEHDLSQISQDVVKNIKQNWERPPLPADFSPSTHTISFQQLDAEEA
ASHNGDSLVRLFGVTENGHSIVCDMTGFNHYFYFPVPVDFRKPEIPQLIEHIKTKELGSIKDIEIVLKESIWGYNGNVKS
PFLKIFCSDTRSIQRIRAAFERGEINFSANGLVFFNSPATSYDNINYVLRAMIDCKITGMSWITLPAGKYKEIPKNKRLS
RCQIEVEIDYKDIVPHAAEGDWSKMAPLRILSFDIECAGRKGVFPEAEIDPVIQIANTVNTYGESTPFIRNVFTLNTCSP
IVSTQIIENDTERELLLRWRDFVRKSDPDVIIGYNTTNFDFPYLLDRAEALGLHDFPYFGRMTNIKQQAKKTTFNSKAFG
ASESKAINIDGRMQFDMLQFIRREFKLRSYTLNSVSAHFLGEQKEDVHHSIITDLQNGNGETRRRLAVYCLKDAFLPMRL
MEKLMCLVNYTEMARVTGVPFSYLLTRGQQIKVISQLFRKTLELDFVIPNMRSEGSSDEQYEGATVIEPIRGYYDVPIAT
LDFSSLYPSIMMAHNLCYTTLLDKQTIERLNLKESEDYTKTPNGDFFVKSKLRHGILPDVLNELLSARKRAKADLKKETD
PFKRAILDGRQLALKISANSVYGFTGATIGKLPCLAISSSVTSFGREMIERTKNEVEQKYTLKNGYSHDATVIYGDTDSV
MVKFGPNDLETCMKMGLEAADFVSTKFMKPIKLEFEKVYFPYLLINKKRYAGLYWTKTDKPDKMDTKGIETVRRDNCRLV
QNVIETVLQKVLRERDVNGAEAYVKMVISKLMQNQIDMSLLVITKQISRADYAAKQAHVELAERMRKRDPGSAPQLGDRV
PYVIIKGGVNGKNYEKSEDPIYVLEHNLPIDTKYYLDNQLSNPLTRIFEPILGQKKAHLLLTGDHTRTIRVAAPTTGGLM
KFAVKTEVCMHCKRPLKRKKNNSTNSMMKSGPSLSKFGGKENLNTTVSISAAEKNDSVYDEEKGALCLDCLDYAPYYYQS
TITKLNSLEYKFSKLWTECQRCQGEMHQEVLCSSKDCPIFYMRKKAQKDVIACAKDLARFDYTEW

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity

Cellular Component

None predicted.