Protein

MCA_03146_1

Length
1,095 amino acids

Gene name: POL3

Description: DNA polymerase delta catalytic subunit

Browser: contigB:3487732-3491135+

RNA-seq: read pairs 1018, FPKM 11.5, percentile rank 28.4% (100% = highest expression)

Protein function

Annotation:POL3DNA polymerase delta catalytic subunit
KEGG:K02327POLD1 DNA polymerase delta subunit 1 [EC:2.7.7.7]
EGGNOG:0PGECPOL3DNA Polymerase
SGD closest match:S000002260POL3DNA polymerase delta catalytic subunit

Protein alignments

%idAln lengthE-value
MIA_00377_174.82%10960.0MIA_00377_1
A0A0J9XGP4_GEOCN73.51%10380.0DNA polymerase OS=Geotrichum candidum GN=BN980_GECA16s02067g PE=3 SV=1
A0A060T781_BLAAD68.54%10330.0DNA polymerase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B21362g PE=3 SV=1
A0A1E3PEB0_9ASCO67.67%10640.0DNA polymerase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_62083 PE=3 SV=1
Q6CHI6_YARLI67.12%10370.0DNA polymerase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A08426g PE=3 SV=1
A0A1D8PR64_CANAL63.60%10880.0DNA polymerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=POL3 PE=3 SV=1
UniRef50_P4658863.60%10880.0DNA polymerase delta catalytic subunit n=119 Tax=Eukaryota TaxID=2759 RepID=DPOD_CANAX
A0A167DI13_9ASCO69.97%9390.0DNA polymerase OS=Sugiyamaella lignohabitans GN=POL3 PE=3 SV=1
A0A1E4TLF2_9ASCO60.84%10750.0DNA polymerase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_89320 PE=3 SV=1
DPOD_YEAST58.91%10270.0DNA polymerase delta catalytic subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=POL3 PE=1 SV=4

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1451

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 900 1000 1095

Detailed signature matches

  1. Family IPR006172
    DNA-directed DNA polymerase, family B
    1. PR00106 (DNAPOLB)
    2. SM00486 (polmehr3)
  2. Domain IPR012337
    Ribonuclease H-like domain
    1. SSF53098 (Ribonucle...)
    2. G3DSA:3.30.42...
  3. Domain IPR006133
    DNA-directed DNA polymerase, family B, exonuclease domain
    1. PF03104 (DNA_pol_B_...)
  4. Domain IPR006134
    DNA-directed DNA polymerase, family B, multifunctional domain
    1. PF00136 (DNA_pol_B)
  5. Domain IPR023211
    DNA polymerase, palm domain
    1. G3DSA:3.90.16...
  6. Domain IPR025687
    C4-type zinc-finger of DNA polymerase delta
    1. PF14260 (zf-C4pol)
  7. SITE IPR017964
    DNA-directed DNA polymerase, family B, conserved site
    1. PS00116 (DNA_POLYME...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.34...
  2. SSF56672 (DNA/RNA p...)
  3. TIGR00592
  4. cd05533 (POLBc_delta)
  5. cd05777 (DNA_polB_d...)
  6. mobidb-lite (disord...)

Residue annotation

  1. active site cd05777
  2. catalytic site cd0...
  3. substrate binding ...
  4. active site cd05533
  5. metal-binding site...

Protein sequence

>MCA_03146_1
MTAELISLDPISNSSSQAINKRISPASSQFSKRQKTDEPTEFEKDLLKLEEDRRSANEAFSYDQHWNRPPIENFDPATSS
INFQQLDAEEAVLNDEPILRLFGVTENGHSILCDMTGFWHYFYFPAPVGFRKENIPALVNHLSNLNIGKIRRIDLVLKES
IWGYNGNVKSPFLQIFCSDLRSIQHFRSAFERGQINFKHPSDNIMFSTPGTSYDNINYVLRAMIDNGITGMSWITLPAGK
YKVVSDSEKQSRCQLEIRISYKDLIAHPADGEWSKIAPLRILSFDIECAGRKGVFPEAEIDPVIQIANTVNLYGESRPFV
RNVFTLGTCSPIVGSQIIENKTEEEMLRGWRDFVRRVDPDVIIGYNIVNFDLPYLMDRAEALKVRDFPYFGRMKNIKQEI
RNTTFSSKAFGSSESKAINIDGRVQFDMLQFIRREFKLRTYTLNAVSSHFLGEQKEDVHHSIITDLQNGNAETRRRLAVY
CLKDAFLPMRLMEKLMCLVNYTEMARVTGVPFSYLLTRGQQIKVISQLFRKTLSIGLVIPNMKQTGNTDEQYEGATVIEP
KRGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLSKETIARLNLEEDKDYTRTPTGDCFIKSEVRKGILPDILEQLISARK
RAKADLKKETDPFKRAILDGRQLALKISANSVYGFTGATIGKLPCLEISSSVTAFGRVMIEQTKSSVEEKYTIANGYTHD
AVVIYGDTDSVMVKFGPNDLPKCMELGMEAADFVSQKFKKPVKLEFEKVYYPYLLINKKRYAGIYWTKTDKPDKMDTKGI
ETVRRDNCRLVPHVIETVLQKVLMERDVPGAEEYVKKIISQLMQNQIDMSQLVITKQLSRSDYAAKQAHVELAERMRKRD
PGSAPALGDRVAYVIIKSGLSGKNYEKSEDPIYVLEHNLPIDTDYYLENQLSNPLQRIFEPILGAKRAHQLLHGDHTRKI
TVAAPTSGGLMKFAVKKAACRHCHRPLDRNPKRKLSSGKSGKKNTNDDDLIMDGALCLDCLVYAPQYYQSTLRQLNALET
KFSRLWTECQRCQGEMHQPVLCSSKDCPIFYMRTKAQKDLVACSKELGKFDHTDW

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity

Cellular Component

None predicted.