MIA_00357_1

Protein

Length

271 amino acids

Protein function

EGGNOG:	0PFIV	URA3	orotidine 5-phosphate decarboxylase
SGD closest match:	S000000747	URA3	Orotidine 5'-phosphate decarboxylase
CGD closest match:	CAL0000191638	URA3	Orotidine 5'-phosphate decarboxylase

Protein alignments

	%id	Aln length	E-value
MCA_05298_1	78.309%	272	4.33e-150	MCA_05298_1
M1X4Q4_GEOCN	76.493%	268	3.02e-139	Orotidine 5'-phosphate decarboxylase OS=Geotrichum candidum GN=URA3 PE=3 SV=1
A0A060T597_BLAAD	74.170%	271	4.02e-135	Orotidine 5'-phosphate decarboxylase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B02882g PE=3 SV=1
A0A167C0B0_9ASCO	73.333%	270	3.09e-133	Orotidine 5'-phosphate decarboxylase OS=Sugiyamaella lignohabitans GN=URA3 PE=3 SV=1
A0A1E3PET0_9ASCO	66.171%	269	3.70e-118	Orotidine 5'-phosphate decarboxylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_28017 PE=3 SV=1
UniRef50_P33283	66.667%	264	2.86e-112	Orotidine 5'-phosphate decarboxylase n=205 Tax=Opisthokonta TaxID=33154 RepID=PYRF_CANGA
PYRF_CANAL	66.165%	266	1.26e-114	Orotidine 5'-phosphate decarboxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=URA3 PE=3 SV=4
PYRF_YARLI	60.142%	281	8.44e-111	Orotidine 5'-phosphate decarboxylase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=URA3 PE=3 SV=1
PYRF_YEAST	65.038%	266	7.16e-111	Orotidine 5'-phosphate decarboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URA3 PE=1 SV=2
A0A1E4TLC4_9ASCO	60.606%	264	5.75e-104	Orotidine 5'-phosphate decarboxylase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_86916 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2076

Protein family membership

Orotidine 5'-phosphate decarboxylase (IPR014732)

Domains and repeats

Domain
2 - 271
Aldolase-type TIM barrel (IPR013785)
Ribulose-phosphate binding barrel (IPR011060)
Orotidine 5'-phosphate decarboxylase domain (IPR001754)

1 50 100 150 200 271

Detailed signature matches

IPR014732

Orotidine 5'-phosphate decarboxylase
1. TIGR01740
  
  34 - 258
  
  TIGRFAMs
  TIGR01740 (TIGR01740)
IPR013785

Aldolase-type TIM barrel
1. G3DSA:3.20.20.70
  
  2 - 271
  
  GENE3D
  G3DSA:3.20.20.70 (G3DSA:3.20.20.70)
IPR011060

Ribulose-phosphate binding barrel
1. SSF51366 (Ribulose-...)
  
  5 - 268
  
  SUPERFAMILY
  SSF51366 (Ribulose-phoshate binding barrel)
IPR001754

Orotidine 5'-phosphate decarboxylase domain
1. SM00934 (OMPdecase_2)
  
  33 - 256
  
  SMART
  SM00934 (OMPdecase_2)
2. PF00215 (OMPdecase)
  
  32 - 257
  
  Pfam
  PF00215 (OMPdecase)
IPR018089

Orotidine 5'-phosphate decarboxylase, active site
1. PS00156 (OMPDECASE)
  
  90 - 103
  
  PROSITE patterns
  PS00156 (OMPDECASE)

no IPR

Unintegrated signatures

cd04725 (OMP_decarb...)

34 - 257

CDD
cd04725 (OMP_decarboxylase_like)

Residue annotation

active site cd04725

37S

active site
37S, 39D, 61K, 63H, 93D, 95K, 160L, 161S, 208P, 240G, 241R
CDD
cd04725 (OMP_decarboxylase_like)

39D

active site
37S, 39D, 61K, 63H, 93D, 95K, 160L, 161S, 208P, 240G, 241R
CDD
cd04725 (OMP_decarboxylase_like)

61K

active site
37S, 39D, 61K, 63H, 93D, 95K, 160L, 161S, 208P, 240G, 241R
CDD
cd04725 (OMP_decarboxylase_like)

63H

active site
37S, 39D, 61K, 63H, 93D, 95K, 160L, 161S, 208P, 240G, 241R
CDD
cd04725 (OMP_decarboxylase_like)

93D

active site
37S, 39D, 61K, 63H, 93D, 95K, 160L, 161S, 208P, 240G, 241R
CDD
cd04725 (OMP_decarboxylase_like)

95K

active site
37S, 39D, 61K, 63H, 93D, 95K, 160L, 161S, 208P, 240G, 241R
CDD
cd04725 (OMP_decarboxylase_like)

160L

active site
37S, 39D, 61K, 63H, 93D, 95K, 160L, 161S, 208P, 240G, 241R
CDD
cd04725 (OMP_decarboxylase_like)

161S

active site
37S, 39D, 61K, 63H, 93D, 95K, 160L, 161S, 208P, 240G, 241R
CDD
cd04725 (OMP_decarboxylase_like)

208P

active site
37S, 39D, 61K, 63H, 93D, 95K, 160L, 161S, 208P, 240G, 241R
CDD
cd04725 (OMP_decarboxylase_like)

240G

active site
37S, 39D, 61K, 63H, 93D, 95K, 160L, 161S, 208P, 240G, 241R
CDD
cd04725 (OMP_decarboxylase_like)

241R

active site
37S, 39D, 61K, 63H, 93D, 95K, 160L, 161S, 208P, 240G, 241R
CDD
cd04725 (OMP_decarboxylase_like)
dimer interface cd...

63H

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

65D

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

66I

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

94R

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

95K

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

97A

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

98D

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

101S

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

102T

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

105A

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

106Q

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

124H

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

125S

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

126V

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

137E

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

160L

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

171Y

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

241R

dimer interface
63H, 65D, 66I, 94R, 95K, 97A, 98D, 101S, 102T, 105A, 106Q, 124H, 125S, 126V, 137E, 160L, 171Y, 241R
CDD
cd04725 (OMP_decarboxylase_like)

Protein sequence

>MIA_00357_1
MSNITKTYEERAAVHKSHTAKRLLTLMAEKKTNLCASLDVTTTAELLRLADILGPYISLVKTHIDIVSDFSYEGTIVPLV
ELSKKHNFLIFEDRKFADIGSTVKAQYSSGVYKIVQWADITNAHSVPGEGIISGLREAAHEYIEANGNKTDRGLIMLAEL
SSKGSLAVGEYTAQTVAMARRNLDFVFGFIAQNRMEEGEGEDLLILTPGVGLDDKGDGLGQQYRTVDTVIKGGSDVIIVG
RGLFGKGRDPEAEGKRYRDAGWAAYEARVSK

GO term prediction

Biological Process

GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0008152 metabolic process
GO:0044205 'de novo' UMP biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0004590 orotidine-5'-phosphate decarboxylase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features