Protein

MCA_05298_1

Length
275 amino acids

Gene name: URA3

Description: Orotidine 5'-phosphate decarboxylase

Browser: contigD:936450-937278+

RNA-seq: read pairs 2272, FPKM 101.7, percentile rank 79.0% (100% = highest expression)

Protein function

Annotation:URA3Orotidine 5'-phosphate decarboxylase
KEGG:K01591pyrF orotidine-5'-phosphate decarboxylase [EC:4.1.1.23]
EGGNOG:0PFIVURA3orotidine 5-phosphate decarboxylase
SGD closest match:S000000747URA3Orotidine 5'-phosphate decarboxylase
CGD closest match:CAL0000191638URA3Orotidine 5'-phosphate decarboxylase

Protein alignments

%idAln lengthE-value
MIA_00357_178.31%2721e-158MIA_00357_1
M1X4Q4_GEOCN79.48%2688e-156Orotidine 5'-phosphate decarboxylase OS=Geotrichum candidum GN=URA3 PE=3 SV=1
A0A060T597_BLAAD77.78%2701e-155Orotidine 5'-phosphate decarboxylase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B02882g PE=3 SV=1
A0A167C0B0_9ASCO72.32%2718e-144Orotidine 5'-phosphate decarboxylase OS=Sugiyamaella lignohabitans GN=URA3 PE=3 SV=1
PYRF_CANAL66.67%2708e-130Orotidine 5'-phosphate decarboxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=URA3 PE=3 SV=4
UniRef50_P3328366.92%2631e-124Orotidine 5'-phosphate decarboxylase n=205 Tax=Opisthokonta TaxID=33154 RepID=PYRF_CANGA
A0A1E3PET0_9ASCO64.81%2704e-127Orotidine 5'-phosphate decarboxylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_28017 PE=3 SV=1
PYRF_YEAST62.96%2702e-122Orotidine 5'-phosphate decarboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URA3 PE=1 SV=2
PYRF_YARLI61.21%2816e-122Orotidine 5'-phosphate decarboxylase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=URA3 PE=3 SV=1
A0A1E4TLC4_9ASCO60.08%2634e-117Orotidine 5'-phosphate decarboxylase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_86916 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0065

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 275

Detailed signature matches

  1. Family IPR014732
    Orotidine 5'-phosphate decarboxylase
    1. TIGR01740
  2. Domain IPR013785
    Aldolase-type TIM barrel
    1. G3DSA:3.20.20.70
  3. Domain IPR011060
    Ribulose-phosphate binding barrel
    1. SSF51366 (Ribulose-...)
  4. Domain IPR001754
    Orotidine 5'-phosphate decarboxylase domain
    1. SM00934 (OMPdecase_2)
    2. PF00215 (OMPdecase)
  5. SITE IPR018089
    Orotidine 5'-phosphate decarboxylase, active site
    1. PS00156 (OMPDECASE)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd04725 (OMP_decarb...)

Residue annotation

  1. active site cd04725
  2. dimer interface cd...

Protein sequence

>MCA_05298_1
MPIDNTKLKYEQRAEKHSSATAKRLLNLMAAKETNLCASLDVRSTAEVLRLADVLGPYVCMVKTHMDIVDDFTYEGTIKP
LVELAKKHQFMIFEDRKFADIGSTVKAQYEGGVYKIVEWADITNAHSVPGEGIVTGLKSAATEFVERNSGATDRGLIMLA
ELSSKGSLAVGEYTQKTVEIARNNKDFVFGFIAQNRMPEVGEDEDWLVLTPGVGLDDKGDALGQQYRTVDTVVKGGSDVI
IVGRGLFGKGRDPETEGKRYRDAGWSAYKARVSQN

GO term prediction

Biological Process

GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0008152 metabolic process
GO:0044205 'de novo' UMP biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0004590 orotidine-5'-phosphate decarboxylase activity

Cellular Component

None predicted.