MIA_00342_1

Protein

Length

566 amino acids

Protein function

EGGNOG:	0PFST	FG03636.1	MFS transporter (Seo1)
SGD closest match:	S000000062	SEO1	Probable transporter SEO1
CGD closest match:	CAL0000175721	CAALFM_CR06790CA	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MCA_00476_1	61.023%	567	0.0	MCA_00476_1
UniRef50_F2QQK0	57.734%	556	0.0	Biotin symporter n=11 Tax=Saccharomycetales TaxID=4892 RepID=F2QQK0_KOMPC
A0A0J9XCA2_GEOCN	55.797%	552	0.0	Similar to Saccharomyces cerevisiae YAL067C SEO1 Putative permease OS=Geotrichum candidum GN=BN980_GECA09s00208g PE=4 SV=1
A0A060SWU6_BLAAD	57.490%	494	0.0	ARAD1A08228p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A08228g PE=4 SV=1
A0A1E3PTM8_9ASCO	53.480%	546	0.0	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49328 PE=4 SV=1
Q6C1T2_YARLI	47.527%	566	0.0	YALI0F13607p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F13607g PE=4 SV=1
SEO1_YEAST	48.288%	555	0.0	Probable transporter SEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEO1 PE=1 SV=1
Q59MT5_CANAL	45.283%	583	0.0	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR06790CA PE=4 SV=1
A0A161HL86_9ASCO	27.812%	489	1.88e-55	Putative permease SEO1 OS=Sugiyamaella lignohabitans GN=SEO1 PE=4 SV=1
A0A1E4TD78_9ASCO	25.450%	444	7.57e-31	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_142936 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0334
Predicted cleavage: 12

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
95 - 533
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 566

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  121 - 491
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  116 - 531
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  95 - 533
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  117 - 526
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

464 - 474

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

176 - 181

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

233 - 243

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

404 - 414

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

298 - 347

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

531 - 566

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 107

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
Coil

566 - 566

COILS
Coil (Coil)
G3DSA:1.20.12...

334 - 541

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

104 - 307

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

438 - 442

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

367 - 385

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

265 - 275

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

127 - 157

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

201 - 211

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

498 - 508

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

415 - 437

TMHMM
TMhelix (TMhelix)

242 - 264

TMHMM
TMhelix (TMhelix)

274 - 296

TMHMM
TMhelix (TMhelix)

381 - 403

TMHMM
TMhelix (TMhelix)

344 - 366

TMHMM
TMhelix (TMhelix)

108 - 126

TMHMM
TMhelix (TMhelix)

182 - 199

TMHMM
TMhelix (TMhelix)

475 - 497

TMHMM
TMhelix (TMhelix)

209 - 230

TMHMM
TMhelix (TMhelix)

153 - 175

TMHMM
TMhelix (TMhelix)

441 - 463

TMHMM
TMhelix (TMhelix)

508 - 530

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

158 - 175

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

244 - 264

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

212 - 232

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

276 - 297

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

443 - 463

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

386 - 403

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

415 - 437

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

182 - 200

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

509 - 530

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

348 - 366

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

108 - 126

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

475 - 497

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

131Q

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

134I

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

135N

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

136N

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

138Y

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

139V

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

157Q

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

160Y

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

161T

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

164S

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

168Q

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

169L

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

171M

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

172M

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

218E

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

219A

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

222Y

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

223P

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

226H

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

227Y

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

230G

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

242G

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

243G

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

246Y

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

247F

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

253L

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

365N

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

368N

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

369G

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

372I

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

373L

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

386V

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

390S

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

394P

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

397G

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

401I

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

449Q

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

452G

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

453W

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

456S

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

460Y

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

461S

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

464A

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

477T

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

478V

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

481M

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

482N

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

485G

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

486Q

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

489S

putative substrate translocation pore
131Q, 134I, 135N, 136N, 138Y, 139V, 157Q, 160Y, 161T, 164S, 168Q, 169L, 171M, 172M, 218E, 219A, 222Y, 223P, 226H, 227Y, 230G, 242G, 243G, 246Y, 247F, 253L, 365N, 368N, 369G, 372I, 373L, 386V, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481M, 482N, 485G, 486Q, 489S
CDD
cd06174 (MFS)

Protein sequence

>MIA_00342_1
MRGFVKIKQYIPHLRQIDEEKFSSPVNSQITNESVFSLDSTQKNSDTQKDIEEVQVGAQEVEYELRDEANRKWWAIFNEY
EYKRSSGENKTKWYHWFDQNDSPKERKLLMKLDVLLCFFSFVMYWVKYLDQANINNAYVSGMKEDLGMKGNDLVNTQVVY
TVGSVVFQLPMMYLIHRYPTNIILPVMDLGWGLFTLAIYRSHSLRDLQAYRFFVGVFEAAFYPNIHYLFGSWYKPSEYAR
RGGFYYFGQMLGLCTAGLIMSSFIKLDGINGIAGWRWMFIIDSIITIPIAIIGFFVLPGTPKHCYSLFLTDEEIYIARKC
LSEANIAIEEEKSNFFSKSLWKDLLGSWKFYMLVFLSILVSNTSNANNGSFILWLKSLDKYSISKVNNLSSITPALGIIY
IFLTTTLSDKAKSRWGAIIFSQTFNFLGNILLAIWNIPEGAKWIAFCIQYFGWAVSSVIYSWAADTMRHNPQQRAITVVS
MNLIGQASSAVLSILVWKTSEAPRFKKGFSFVSAVSITIMIWATIMLPFYKKDERKHALENGIIVYNSKTDETPRLVEPK
KEALDM

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features