MCA_00476_1

Protein

Length

605 amino acids

RNA-seq: read pairs 19, FPKM 0.4, percentile rank 6.2% (100% = highest expression)

Protein function

EGGNOG:	0PFST	FG03636.1	MFS transporter (Seo1)
SGD closest match:	S000000062	SEO1	Probable transporter SEO1
CGD closest match:	CAL0000175721	CAALFM_CR06790CA	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MIA_00277_1	65.33%	600	0.0	MIA_00277_1
UniRef50_F2QQK0	56.38%	580	0.0	Biotin symporter n=11 Tax=Saccharomycetales TaxID=4892 RepID=F2QQK0_KOMPC
A0A0J9XCA2_GEOCN	54.45%	584	0.0	Similar to Saccharomyces cerevisiae YAL067C SEO1 Putative permease OS=Geotrichum candidum GN=BN980_GECA09s00208g PE=4 SV=1
A0A060SWU6_BLAAD	57.31%	513	0.0	ARAD1A08228p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A08228g PE=4 SV=1
A0A1E3PMS6_9ASCO	53.28%	518	0.0	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46126 PE=4 SV=1
Q6C1T2_YARLI	50.72%	558	0.0	YALI0F13607p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F13607g PE=4 SV=1
SEO1_YEAST	50.47%	529	0.0	Probable transporter SEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEO1 PE=1 SV=1
Q59MT5_CANAL	48.87%	532	0.0	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR06790CA PE=4 SV=1
A0A167CNR4_9ASCO	30.65%	447	3e-61	Putative permease SEO1 OS=Sugiyamaella lignohabitans GN=SEO1 PE=4 SV=1
A0A1E4TIK6_9ASCO	25.59%	426	1e-27	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_72590 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0338

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
118 - 556
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 605

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  140 - 504
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  118 - 556
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  133 - 546
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

424 - 434

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

316 - 369

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

195 - 200

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

484 - 494

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

551 - 605

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 126

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

252 - 262

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

355 - 563

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

123 - 327

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

456 - 460

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

518 - 528

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

146 - 176

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

394 - 404

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

220 - 230

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

284 - 294

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

261 - 283

TMHMM
TMhelix (TMhelix)

409 - 428

TMHMM
TMhelix (TMhelix)

495 - 517

TMHMM
TMhelix (TMhelix)

528 - 550

TMHMM
TMhelix (TMhelix)

127 - 145

TMHMM
TMhelix (TMhelix)

461 - 483

TMHMM
TMhelix (TMhelix)

298 - 320

TMHMM
TMhelix (TMhelix)

201 - 218

TMHMM
TMhelix (TMhelix)

172 - 194

TMHMM
TMhelix (TMhelix)

435 - 457

TMHMM
TMhelix (TMhelix)

372 - 394

TMHMM
TMhelix (TMhelix)

228 - 249

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

295 - 315

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

263 - 283

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

231 - 251

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

201 - 219

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

177 - 194

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

495 - 517

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

127 - 145

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

435 - 455

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

370 - 393

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

461 - 483

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

529 - 550

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

405 - 423

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

580 - 605

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

150Q

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

153V

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

154N

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

155N

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

157Y

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

158V

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

176Q

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

179Y

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

180T

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

183S

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

187Q

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

188I

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

190M

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

191M

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

237E

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

238A

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

241F

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

242P

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

245H

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

246Y

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

249G

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

261G

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

262S

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

265Y

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

266F

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

272L

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

372S

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

375F

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

376L

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

379L

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

380L

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

392L

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

406I

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

410S

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

414P

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

417G

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

421I

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

469Q

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

472G

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

473W

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

476A

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

480F

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

481A

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

484A

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

497T

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

498A

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

501M

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

502N

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

505G

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

506Q

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

509T

putative substrate translocation pore
150Q, 153V, 154N, 155N, 157Y, 158V, 176Q, 179Y, 180T, 183S, 187Q, 188I, 190M, 191M, 237E, 238A, 241F, 242P, 245H, 246Y, 249G, 261G, 262S, 265Y, 266F, 272L, 372S, 375F, 376L, 379L, 380L, 392L, 406I, 410S, 414P, 417G, 421I, 469Q, 472G, 473W, 476A, 480F, 481A, 484A, 497T, 498A, 501M, 502N, 505G, 506Q, 509T
CDD
cd06174 (MFS)

Protein sequence

>MCA_00476_1
MISYQDIKQRWSHTRERVGEFSKKNYAKIRPYVPHLREIDEEYFAQKFNHKRVEVDNADESKFGEDGEKVKVYEHSTEVE
WEIRDEANRKWWSVFNEYEYKHTSTKQSTRKWWHWFEATDTPEEKRLIIKLDILLCFFSFVMYWVKYLDQSNVNNAYVSG
MKEELGMKGNDLVNTQVVYTVGSVVFQIPMMYIIHRYPCHIVIPLMDLGWGLFTLAIYKANSVGELQAYRFFVGAFEAAF
FPTIHYLLGSWYKPSEYARRGSIYYFGQMLGLLTAGLLQSAAYEHLHMTLGISGWRWMFILDTVCSLPIAIYGIWSIPGL
PKKCYSIFLTDEDIYIARKRLTDANISMDTTKTDFFNKDLWKEILCDWKYYSFVFLNILLWNNSNGSSGAYLLWLKSLNE
YSIPMINKLSTITPALGIVWIYMTGAISDLGRSRWGAVVFSQSINCAGNIILAVWDLPKGAIWFAFCLQYFGWAVASIDF
AWAADATRHNPQVRAITAVSMNMFGQATTAFTSVLVWKTVEAPRYLKGYSFTATSAFVMIIWASVILPLYKKDERKHAHE
NGILLYNSALGELPPVPPTEFADLSNAGKNNTDSQVESKTSSEKL

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features