MIA_00277_1

Protein

Length

594 amino acids

Protein function

EGGNOG:	0PFST	FG03636.1	MFS transporter (Seo1)
SGD closest match:	S000000062	SEO1	Probable transporter SEO1
CGD closest match:	CAL0000175721	CAALFM_CR06790CA	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MCA_00476_1	67.250%	571	0.0	MCA_00476_1
UniRef50_F2QQK0	61.101%	545	0.0	Biotin symporter n=11 Tax=Saccharomycetales TaxID=4892 RepID=F2QQK0_KOMPC
A0A0J9XDB5_GEOCN	59.636%	550	0.0	Similar to Saccharomyces cerevisiae YAL067C SEO1 Putative permease OS=Geotrichum candidum GN=BN980_GECA09s00252g PE=4 SV=1
A0A1E3PTM8_9ASCO	55.449%	523	0.0	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49328 PE=4 SV=1
A0A060SWU6_BLAAD	58.683%	501	0.0	ARAD1A08228p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A08228g PE=4 SV=1
Q6C1T2_YARLI	49.053%	581	0.0	YALI0F13607p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F13607g PE=4 SV=1
SEO1_YEAST	50.902%	499	6.24e-176	Probable transporter SEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEO1 PE=1 SV=1
Q59MT5_CANAL	48.333%	540	3.01e-175	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR06790CA PE=4 SV=1
A0A161HL86_9ASCO	28.723%	470	5.85e-62	Putative permease SEO1 OS=Sugiyamaella lignohabitans GN=SEO1 PE=4 SV=1
A0A1E4TD78_9ASCO	26.872%	227	1.31e-26	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_142936 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3268
Predicted cleavage: 18

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
111 - 548
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 594

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  131 - 497
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  111 - 548
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  124 - 537
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

309 - 360

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

243 - 253

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

186 - 191

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

475 - 485

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 117

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

542 - 594

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

415 - 425

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

348 - 553

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

120 - 317

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

449 - 453

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

137 - 167

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

509 - 519

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

386 - 396

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

275 - 285

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

211 - 221

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

163 - 185

TMHMM
TMhelix (TMhelix)

219 - 240

TMHMM
TMhelix (TMhelix)

426 - 448

TMHMM
TMhelix (TMhelix)

192 - 209

TMHMM
TMhelix (TMhelix)

252 - 274

TMHMM
TMhelix (TMhelix)

364 - 386

TMHMM
TMhelix (TMhelix)

118 - 136

TMHMM
TMhelix (TMhelix)

486 - 508

TMHMM
TMhelix (TMhelix)

519 - 541

TMHMM
TMhelix (TMhelix)

401 - 419

TMHMM
TMhelix (TMhelix)

452 - 474

TMHMM
TMhelix (TMhelix)

289 - 311

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

192 - 210

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

286 - 308

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

486 - 508

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

397 - 414

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

168 - 185

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

361 - 385

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

454 - 474

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

222 - 242

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

254 - 274

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

118 - 136

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

426 - 448

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

520 - 541

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

141Q

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

144L

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

145N

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

146N

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

148Y

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

149V

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

167Q

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

170Y

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

171T

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

174S

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

178Q

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

179L

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

181M

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

182M

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

228E

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

229S

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

232Y

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

233P

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

236H

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

237Y

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

240G

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

252G

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

253G

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

256Y

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

257F

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

263L

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

369I

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

372W

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

376N

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

379S

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

380G

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

383L

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

397I

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

401S

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

405P

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

408G

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

412I

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

460Q

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

463G

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

464W

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

467S

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

471Y

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

472S

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

475S

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

488T

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

489V

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

492M

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

493N

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

496G

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

497Q

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

500T

putative substrate translocation pore
141Q, 144L, 145N, 146N, 148Y, 149V, 167Q, 170Y, 171T, 174S, 178Q, 179L, 181M, 182M, 228E, 229S, 232Y, 233P, 236H, 237Y, 240G, 252G, 253G, 256Y, 257F, 263L, 369I, 372W, 376N, 379S, 380G, 383L, 397I, 401S, 405P, 408G, 412I, 460Q, 463G, 464W, 467S, 471Y, 472S, 475S, 488T, 489V, 492M, 493N, 496G, 497Q, 500T
CDD
cd06174 (MFS)

Protein sequence

>MIA_00277_1
MTIKEKFRNFGNRFGQKFDRVRPFIPHLREIDEEVFIQKFETPLDENGEKITGNNRERFTLDREQKKIEYEVRDEANRKW
WALFDEFEYKEHRTGAHVTEHKWYHWFDINDSPEERRVIIKIDILLCFFSFVMYWVKYLDQSNLNNAYVSGMKEDLGMKG
NDLVNTQVVYTVGSVVFQLPMMYLIHRYPTHILLPAMDIAWGLFTLAVYRSSSVGMLQALRFFVGVFESAFYPTIHYLYG
SWYKPSEYARRGGIYYFGQMLGLLTSGLVTAACVENLTGVNGLDGWRWMYIVDAIITIPVAIIGFFVLPGVPKKCYSLFL
SDEEIFIARERLRKANIALETEGPQFFNLQLWKDLLWDWKYYMFVFLNIWGWNNSNGSSGAYLLWLKSLKEYSVPMINKY
STITPALGIVWIYMTGALADHAQSRWGALIFSQSFNLLGNILLAIWYIPKGAVWFGFCLQYFGWASSAVNYSWASDAMRH
NPQHRAITVVSMNMIGQATTAFTSVLVWKTVEAPRFLKGYSFTGTVAFVMMIWATLILPFYKKEERKYAHEQGILLYNSA
KGEVPPTIASSLSDSDELEHEHVVIDDISDEKKQ

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features