Protein

MIA_00338_1

Length
364 amino acids

Browser: contig01:974697-975792+

Protein function

EGGNOG:0PGAEFG09284.1homoserine dehydrogenase
SGD closest match:S000003900HOM6Homoserine dehydrogenase
CGD closest match:CAL0000188452HOM6Homoserine dehydrogenase

Protein alignments

%idAln lengthE-value
MCA_01730_181.044%3640.0MCA_01730_1
A0A060T8V3_BLAAD71.271%3623.24e-170Homoserine dehydrogenase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D14146g PE=3 SV=1
A0A0J9XJF3_GEOCN70.442%3621.85e-166Homoserine dehydrogenase OS=Geotrichum candidum GN=BN980_GECA19s00384g PE=3 SV=1
Q6CAP2_YARLI68.975%3615.13e-159Homoserine dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D01089g PE=3 SV=1
A0A1E3PNM6_9ASCO66.298%3623.34e-157Homoserine dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45979 PE=3 SV=1
A0A161HKL5_9ASCO67.036%3614.68e-155Homoserine dehydrogenase OS=Sugiyamaella lignohabitans GN=HOM6 PE=3 SV=1
DHOM_YEAST64.560%3643.83e-152Homoserine dehydrogenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOM6 PE=1 SV=1
UniRef50_P3111664.560%3649.16e-149Homoserine dehydrogenase n=437 Tax=Fungi TaxID=4751 RepID=DHOM_YEAST
Q5AIA2_CANAL60.773%3627.21e-140Homoserine dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HOM6 PE=3 SV=1
A0A1E4TAX4_9ASCO55.827%3694.00e-123Homoserine dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_131167 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8162

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 364

Detailed signature matches

  1. Family IPR022697
    Homoserine dehydrogenase lacking ACT domain
    1. PIRSF036497 (HDH_short)
  2. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  3. Domain IPR005106
    Aspartate/homoserine dehydrogenase, NAD-binding
    1. PF03447 (NAD_binding_3)
  4. Domain IPR001342
    Homoserine dehydrogenase, catalytic
    1. PF00742 (Homoserine_dh)
  5. SITE IPR019811
    Homoserine dehydrogenase, conserved site
    1. PS01042 (HOMOSER_DH...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.36...
  2. G3DSA:3.40.50...
  3. SSF55347 (Glycerald...)
  4. TMhelix

Protein sequence

>MIA_00338_1
MSQKAVNVAIIGAGLVGSAFINQISRLSKTPIAYNVILIARSTKALISKDYSPLSLSDDWQSRLNSSSDSLSSTGDIAAY
LEKSPLPVILVDNTSNESLAQSYPLLISQGISIATPNKKGFSSDLGLWNSIFEASAKPKGGLVYHEATVGAGLPIIGTLN
DLVNTGDEVLKIEGIFSGSLSFIFNEFSKPTGSDVKFSEIVAKAKELGYTEPDPREDLNGLDVARKVTILSRLAGNKVQG
PSSFPVHSLIPKPLERVETAGEFLEKLPQYDADLDKLRKEAASENKVLRFVGKVDLTQQTPSVAVALEKYDNSHPFASLK
GSDNVIAFTTKRYPNPIIIQGAGAGDAVTAAGVLGDVIKIAQRL

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004412 homoserine dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding

Cellular Component

None predicted.