Protein

MCA_01730_1

Length
367 amino acids

Browser: contigA:5311404-5312508+

RNA-seq: read pairs 4489, FPKM 150.7, percentile rank 84.9% (100% = highest expression)

Protein function

KEGG:K00003E1.1.1.3 homoserine dehydrogenase [EC:1.1.1.3]
EGGNOG:0PGAEFG09284.1homoserine dehydrogenase
SGD closest match:S000003900HOM6Homoserine dehydrogenase
CGD closest match:CAL0000188452HOM6Homoserine dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_00338_181.04%3640.0MIA_00338_1
A0A0J9XJF3_GEOCN71.23%3657e-172Homoserine dehydrogenase OS=Geotrichum candidum GN=BN980_GECA19s00384g PE=3 SV=1
A0A060T8V3_BLAAD71.70%3648e-170Homoserine dehydrogenase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D14146g PE=3 SV=1
Q6CAP2_YARLI69.23%3641e-158Homoserine dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D01089g PE=3 SV=1
A0A1E3PNM6_9ASCO67.03%3642e-158Homoserine dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45979 PE=3 SV=1
A0A161HKL5_9ASCO68.51%3628e-157Homoserine dehydrogenase OS=Sugiyamaella lignohabitans GN=HOM6 PE=3 SV=1
DHOM_YEAST64.56%3648e-149Homoserine dehydrogenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOM6 PE=1 SV=1
UniRef50_P3111664.56%3642e-145Homoserine dehydrogenase n=437 Tax=Fungi TaxID=4751 RepID=DHOM_YEAST
Q5AIA2_CANAL63.56%3652e-139Homoserine dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HOM6 PE=3 SV=1
A0A1E4TAX4_9ASCO56.99%3727e-124Homoserine dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_131167 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8764

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 367

Detailed signature matches

  1. Family IPR022697
    Homoserine dehydrogenase lacking ACT domain
    1. PIRSF036497 (HDH_short)
  2. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  3. Domain IPR005106
    Aspartate/homoserine dehydrogenase, NAD-binding
    1. PF03447 (NAD_binding_3)
  4. Domain IPR001342
    Homoserine dehydrogenase, catalytic
    1. PF00742 (Homoserine_dh)
  5. SITE IPR019811
    Homoserine dehydrogenase, conserved site
    1. PS01042 (HOMOSER_DH...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. G3DSA:3.30.36...
  4. G3DSA:3.40.50...
  5. NON_CYTOPLASM... (N...)
  6. SSF55347 (Glycerald...)
  7. TRANSMEMBRANE (Tran...)

Protein sequence

>MCA_01730_1
MPESKAVNIAIIGAGLVGSAFIRQLKNLAKVSPISYNIILVARSSKALISKDYSPLSLGQDWQSQLNASTESLSSTGDIA
AYLEKSPLPVILVDNTSNESLAQSYPLLIEQGISIATPNKKAFSSGVGLWNNIFAAAAKPKGGLVYHEATVGAGLPIIST
LNDLVNTGDEIVKIEGIFSGTLSYIFNEFSKAPGSGAAVKFSDVVSKAKELGYTEPDPREDLNGLDVARKVTILSRIAGN
KVQDANSFPVKSLIPKPLEKVESVAEFMEKLPQYDGDMEKLRKEAEDENKVLRFVGKVDLSGTPAVSVSIEKYDASHPFA
SLKGSDNIISFTTKRYPNPLIVQGAGAGAEVTAAGVLADVIKAAQRL

GO term prediction

Biological Process

GO:0006520 cellular amino acid metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004412 homoserine dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding

Cellular Component

None predicted.