Protein

MIA_00296_1

Length
659 amino acids


Browser: contig01:848780-850760-

Protein function

EGGNOG:0PGXPACS1Acetate-CoA ligase
SGD closest match:S000004143ACS2Acetyl-coenzyme A synthetase 2

Protein alignments

%idAln lengthE-value
MCA_01134_189.498%6570.0MCA_01134_1
A0A0J9XH17_GEOCN89.498%6570.0Acetyl-coenzyme A synthetase OS=Geotrichum candidum GN=BN980_GECA16s00208g PE=3 SV=1
A0A060T8N5_BLAAD79.452%6570.0Acetyl-coenzyme A synthetase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D12826g PE=3 SV=1
A0A1E3PPW9_9ASCO75.789%6650.0Acetyl-coenzyme A synthetase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81952 PE=3 SV=1
Q6C2Q5_YARLI78.241%6480.0Acetyl-coenzyme A synthetase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F05962g PE=3 SV=1
A0A1E4TAC1_9ASCO71.341%6560.0Acetyl-coenzyme A synthetase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3299 PE=3 SV=1
A0A167BYL8_9ASCO72.188%6400.0Acetyl-coenzyme A synthetase OS=Sugiyamaella lignohabitans GN=ACS2 PE=3 SV=1
UniRef50_G0RZW269.909%6580.0Acetyl-coenzyme A synthetase-like protein n=1 Tax=Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) TaxID=759272 RepID=G0RZW2_CHATD
Q59XW4_CANAL68.293%6560.0Acetyl-coenzyme A synthetase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ACS1 PE=3 SV=1
ACS2_YEAST62.425%6680.0Acetyl-coenzyme A synthetase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACS2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0143

Protein family membership

Domains and repeats

1 100 200 300 400 500 600 659

Detailed signature matches

    1. cd05966 (ACS)
    1. PF16177 (ACAS_N)
    1. PF00501 (AMP-binding)
    1. PF13193 (AMP-binding_C)
    1. PS00455 (AMP_BINDING)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF56801 (Acetyl-Co...)

Residue annotation

  1. CoA binding site c...
  2. active site cd05966
  3. acyl-activating en...
  4. acetate binding si...
  5. AMP binding site c...

Protein sequence

>MIA_00296_1
MSVAESSNIHKYAPPKEFHENHPGKPHLDNVAHYEELYKESIEQPEAFFGKIARQLLSWDKDFQTVLNGGFEHGDAAWFL
EGELNACYNAVDRHALKNPDKVAIIYEADEPGEGRNVTYGELLREVSRVAAVLASFGVKKGDTVAVYLPMIPEAIVTLLA
IVRLGAIHSVVFAGFSSGSLRDRIVDADSRVVITTDESKRGGRVIETKKIVDEALKSCPNVKHTLVFKRTGNESIPWNKD
RDYWWHEEVEKHRPYFPPVSVNSEDPIFLLYTSGSTGSPKGVAHATAGYLLGAATTTKYVFDLHPDDILFTAGDVGWITG
HTYVCYGPLLLGATTVVFEGTPAFPNFSRLWDIIDAHKVTHFYVAPTALRLLKRAGLEWINHDLSSLRTLGSVGEPIAPD
VWEWYNDNIGKGKAHICDTYWQTETGSHIISPMAGVTHTKPGSASFPVFGIDPVIIDPVSGQELKGNDVEGVLAIRNPWP
SMARTVWNSHKRYLETYLKPYPGYYFTGDGAARDHEGYYWIRGRVDDVVNVSGHRLSTAEIEAALIEHPAVAESAVVGIS
DDLTGQAVNAFVALKVKPTDVAATKKELILQVRKTIGPFAAPKNVLIVEDLPKTRSGKIMRRILRKVLSGEEDSLGDIST
LSNPEAVENIIAICKAERK

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0019427 acetyl-CoA biosynthetic process from acetate

Molecular Function

GO:0003824 catalytic activity
GO:0003987 acetate-CoA ligase activity
GO:0016208 AMP binding

Cellular Component

None predicted.