MIA_00278_1

Protein

Length

581 amino acids

Protein function

EGGNOG:	0PFST	FG03636.1	MFS transporter (Seo1)
SGD closest match:	S000000062	SEO1	Probable transporter SEO1
CGD closest match:	CAL0000175721	CAALFM_CR06790CA	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MCA_00476_1	68.909%	550	0.0	MCA_00476_1
UniRef50_F2QQK0	59.041%	542	0.0	Biotin symporter n=11 Tax=Saccharomycetales TaxID=4892 RepID=F2QQK0_KOMPC
A0A0J9XDB5_GEOCN	59.279%	555	0.0	Similar to Saccharomyces cerevisiae YAL067C SEO1 Putative permease OS=Geotrichum candidum GN=BN980_GECA09s00252g PE=4 SV=1
A0A060SWU6_BLAAD	54.963%	544	0.0	ARAD1A08228p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A08228g PE=4 SV=1
A0A1E3PTM8_9ASCO	56.008%	516	0.0	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49328 PE=4 SV=1
Q6C1T2_YARLI	50.564%	532	0.0	YALI0F13607p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F13607g PE=4 SV=1
SEO1_YEAST	51.606%	498	0.0	Probable transporter SEO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEO1 PE=1 SV=1
Q59MT5_CANAL	47.834%	531	0.0	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR06790CA PE=4 SV=1
A0A161HL86_9ASCO	29.536%	474	4.82e-65	Putative permease SEO1 OS=Sugiyamaella lignohabitans GN=SEO1 PE=4 SV=1
A0A1E4TD78_9ASCO	24.123%	456	6.33e-31	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_142936 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7622

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
98 - 539
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 581

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  120 - 487
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  98 - 539
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  113 - 526
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

531 - 581

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

232 - 242

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

298 - 349

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 106

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

464 - 474

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

175 - 180

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

404 - 414

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

337 - 542

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

103 - 307

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

498 - 508

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

200 - 210

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

375 - 385

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

264 - 274

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

126 - 156

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

438 - 442

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

415 - 437

TMHMM
TMhelix (TMhelix)

508 - 530

TMHMM
TMhelix (TMhelix)

207 - 229

TMHMM
TMhelix (TMhelix)

441 - 463

TMHMM
TMhelix (TMhelix)

241 - 263

TMHMM
TMhelix (TMhelix)

107 - 125

TMHMM
TMhelix (TMhelix)

278 - 300

TMHMM
TMhelix (TMhelix)

475 - 497

TMHMM
TMhelix (TMhelix)

389 - 408

TMHMM
TMhelix (TMhelix)

152 - 174

TMHMM
TMhelix (TMhelix)

181 - 203

TMHMM
TMhelix (TMhelix)

352 - 374

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

443 - 463

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

386 - 403

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

157 - 174

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

181 - 199

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

509 - 530

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

415 - 437

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

275 - 297

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

107 - 125

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

475 - 497

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

350 - 374

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

243 - 263

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

211 - 231

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

130Q

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

133L

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

134N

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

135N

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

137Y

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

138V

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

156Q

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

159Y

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

160T

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

163S

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

167Q

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

168I

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

170M

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

171M

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

217E

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

218S

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

221Y

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

222P

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

225H

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

226Y

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

229G

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

241G

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

242G

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

245Y

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

246F

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

252L

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

350Y

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

353Y

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

354V

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

357G

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

358I

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

372L

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

386I

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

390S

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

394P

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

397G

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

401I

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

449Q

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

452G

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

453W

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

456S

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

460Y

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

461S

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

464A

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

477T

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

478V

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

481I

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

482N

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

485G

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

486Q

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

489T

putative substrate translocation pore
130Q, 133L, 134N, 135N, 137Y, 138V, 156Q, 159Y, 160T, 163S, 167Q, 168I, 170M, 171M, 217E, 218S, 221Y, 222P, 225H, 226Y, 229G, 241G, 242G, 245Y, 246F, 252L, 350Y, 353Y, 354V, 357G, 358I, 372L, 386I, 390S, 394P, 397G, 401I, 449Q, 452G, 453W, 456S, 460Y, 461S, 464A, 477T, 478V, 481I, 482N, 485G, 486Q, 489T
CDD
cd06174 (MFS)

Protein sequence

>MIA_00278_1
MTASAFKQKFHNFQRKIKPYIPHLREINEQHFIEKFSSKEKTNNRDRFTVGQYGNELVYEVRDEANRKWWALFDEYEYKR
NHNQETQTTHKWYHWFDENDSPEERRLIIKLDILLCFFSFVMYWVKYLDQSNLNNAYVSGMKEDLGMKGNDLVNTQVVYT
VGSVVFQIPMMYLIHRYPSNVLLPSMDIAWGLFTLAIYRSTSVGMLQALRFFVGVFESAFYPTIHYLYGSWYKPAEYTRR
GGIYYFGQMLGLLTSGLITASCVENLTSVNGLEGWRWMYIVDAIITLPVAILGFYMLPGVPKQCHSLFLTDEDIFVARER
LRKANIALETEGPQFFSWTLWKDLLWDWKYYAYVILGIWAWNNSNGSSGAYLLWLKSLKQYSVPMINKYSTITPALGIVW
IYMTSAIADHARSRWGAIIFSQVFNLVGNIMLAVWYIPKGATWFAFCLQYFGWASSSVIYSWAADAMRHNPQQRAITVVS
INMIGQATTAFTSVLVWKTVEAPRYLKGYSFTCTVIVVMMIWATLMLPFYKKEERKHAHEQGILLYNSAKGEEPPSVSQY
TQNDDDVEYVQQYIVEEDKKV

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features