Protein

MIA_00272_1

Length
1,030 amino acids

Browser: contig01:772896-775989+

Protein function

EGGNOG:0PJKKPLC1phospholipase C
SGD closest match:S000006189PLC11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
CGD closest match:CAL0000200735PLC1Phosphoinositide phospholipase C

Protein alignments

%idAln lengthE-value
MCA_02685_146.828%6620.0MCA_02685_1
A0A0J9XFP1_GEOCN39.407%6753.68e-124Phosphoinositide phospholipase C OS=Geotrichum candidum GN=BN980_GECA13s03761g PE=4 SV=1
UniRef50_A0A0J9XFP139.407%6757.54e-121Phosphoinositide phospholipase C n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XFP1_GEOCN
Q6CD33_YARLI36.298%6971.30e-105Phosphoinositide phospholipase C OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C04180g PE=4 SV=1
A0A167DIP4_9ASCO34.639%6641.81e-103Phosphoinositide phospholipase C OS=Sugiyamaella lignohabitans GN=PLC1 PE=4 SV=1
A0A060T1S3_BLAAD36.449%6425.52e-103Phosphoinositide phospholipase C OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A02420g PE=4 SV=1
A0A1E3PQC5_9ASCO33.092%6924.75e-89Phosphoinositide phospholipase C OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81973 PE=4 SV=1
A0A1E4TKN9_9ASCO33.546%6269.24e-88Phosphoinositide phospholipase C OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_886 PE=4 SV=1
A0A1D8PRE4_CANAL28.287%6549.46e-71Phosphoinositide phospholipase C OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PLC1 PE=4 SV=1
PLC1_YEAST33.279%6101.95e-711-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PLC1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0219

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 900 1030

Detailed signature matches

  1. Family IPR001192
    Phosphoinositide phospholipase C family
    1. PR00390 (PHPHLIPASEC)
  2. Domain IPR011993
    PH domain-like
    1. G3DSA:2.30.29.30
    2. SSF50729 (PH domain...)
  3. Domain IPR011992
    EF-hand domain pair
    1. SSF47473 (EF-hand)
  4. Domain IPR017946
    PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
    1. SSF51695 (PLC-like ...)
    2. G3DSA:3.20.20...
  5. Domain IPR000909
    Phosphatidylinositol-specific phospholipase C, X domain
    1. SM00148 (plcx_3)
    2. PS50007 (PIPLC_X_DO...)
    3. PF00388 (PI-PLC-X)
  6. Domain IPR001711
    Phospholipase C, phosphatidylinositol-specific, Y domain
    1. SM00149 (plcy_3)
    2. PF00387 (PI-PLC-Y)
    3. PS50008 (PIPLC_Y_DO...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.23...
  2. cd08598 (PI-PLC1c_y...)
  3. mobidb-lite (disord...)

Residue annotation

  1. catalytic site cd0...
  2. putative active si...
  3. putative Ca bindin...

Protein sequence

>MIA_00272_1
MIIASPEVAPSDIPATTEDTLDPLQLSQADLAPVSPAQPPSVPSRASSPLFIATNVASPTASQPQLQPAFAAPPPIPQLH
QPQPSAGFALTAAITATAISPRSRAPLASPSLQSRAQPSSLPKPINPAAAAAANLASLGALSYGGLMSPTSPPQSQSRSP
SRHASTSSRHKSTSLSRHASTSSRRGTSPMTALFRSASQRRPSRVTTDPITMMDSCRPTTIKKTLKHSLTFPLDTLSSTE
GSDSRKSSLGSLLSSPTTPITVFSPMEDGGKAIVLHQPQAGSHACHEVIIPHELCQGVSMYRVTHKKAKLRTIKLRPRGT
TFVISWEDDKESSTFDVDDITGIRLGKQARYYQNELCKVMSKPEDYDKWITIVYSPSPNAPGYKDNKIVRELHVVAETQR
GFELVCSTIINLCAFRQHSDSILSIDPSVIAYEWHQLRIQELPSDKVDMMLLKHNIHCSRAFLDMKKQEANGMKKTFSSS
EFLKLLKLLNERPEIDRIWEAHKDSTSGMTFEGFEKFCREVQGMEGRREDFDKYEKEGVLSSEGLRLFLESLPVVDPPKQ
DLTRGIHNYFISSSHNTYLPGWQVLSYSSPEPYVRGLLDKCRCVEIDVWDGDTGPIVTHGRTFTSAVEFSSVVHAINEFA
FVESRLPVILSFEIHCSGENQVKMVKIMKEVFGDKLVTSSGGVDGGLGSERIQMPHSYYRPAPEDLLDKILVKVKAASGA
NERKWSVGQNFGQEVGSNGADSDSSGEEKGTSNAGGGNKKKPQKSKITPELGSLGVYFQGVKFRGFNTSEAKTVSHIFSF
NDAKVNAIILNKENSEGEGREEGMFIHHNRGYFSRVYPHNLRISSSNYDPIPYWRRGVQMVALNWQNCDTSKQLNDAMFE
GTDGFVLKPECEEEERRPRGRRRVVVEVISLRHLPRPRGVEKRVDGDGYEGGSGELNGGDGVGDGVVVSLEMFGAVEHQN
YLPKESKGEGLRKALLGSGRAGSKGDPEKISRAEPVWYSKPVGTIRSMRSGGGRVAGGAGGPQGKGWGSG

GO term prediction

Biological Process

GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction

Molecular Function

GO:0004435 phosphatidylinositol phospholipase C activity
GO:0008081 phosphoric diester hydrolase activity

Cellular Component

None predicted.