Protein

MCA_02685_1

Length
1,296 amino acids

Gene name: PLC1

Description: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

Browser: contigB:2046352-2050243-

RNA-seq: read pairs 2506, FPKM 23.9, percentile rank 46.3% (100% = highest expression)

Protein function

Annotation:PLC11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
KEGG:K05857PLCD phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
EGGNOG:0PJKKPLC1phospholipase C
SGD closest match:S000006189PLC11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
CGD closest match:CAL0000200735PLC1Phosphoinositide phospholipase C

Protein alignments

%idAln lengthE-value
MIA_00272_142.42%7783e-178MIA_00272_1
A0A0J9XFP1_GEOCN39.02%6563e-126Phosphoinositide phospholipase C OS=Geotrichum candidum GN=BN980_GECA13s03761g PE=4 SV=1
UniRef50_A0A0J9XFP139.02%6566e-123Phosphoinositide phospholipase C n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XFP1_GEOCN
A0A060T1S3_BLAAD38.27%6141e-113Phosphoinositide phospholipase C OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A02420g PE=4 SV=1
A0A167DIP4_9ASCO35.21%6394e-111Phosphoinositide phospholipase C OS=Sugiyamaella lignohabitans GN=PLC1 PE=4 SV=1
Q6CD33_YARLI36.58%6371e-108Phosphoinositide phospholipase C OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C04180g PE=4 SV=1
A0A1E3PQC5_9ASCO33.61%7173e-103Phosphoinositide phospholipase C OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81973 PE=4 SV=1
A0A1D8PRE4_CANAL32.82%6469e-85Phosphoinositide phospholipase C OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PLC1 PE=4 SV=1
PLC1_YEAST32.45%6418e-741-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PLC1 PE=1 SV=1
A0A1E4TKN9_9ASCO36.07%4381e-70Phosphoinositide phospholipase C OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_886 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0816

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1296

Detailed signature matches

  1. Family IPR001192
    Phosphoinositide phospholipase C family
    1. PR00390 (PHPHLIPASEC)
  2. Domain IPR011993
    PH domain-like
    1. SSF50729 (PH domain...)
  3. Domain IPR011992
    EF-hand domain pair
    1. SSF47473 (EF-hand)
  4. Domain IPR017946
    PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
    1. SSF51695 (PLC-like ...)
    2. G3DSA:3.20.20...
  5. Domain IPR000909
    Phosphatidylinositol-specific phospholipase C, X domain
    1. SM00148 (plcx_3)
    2. PS50007 (PIPLC_X_DO...)
    3. PF00388 (PI-PLC-X)
  6. Domain IPR001711
    Phospholipase C, phosphatidylinositol-specific, Y domain
    1. SM00149 (plcy_3)
    2. PF00387 (PI-PLC-Y)
    3. PS50008 (PIPLC_Y_DO...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.23...
  2. cd08598 (PI-PLC1c_y...)
  3. mobidb-lite (disord...)

Residue annotation

  1. catalytic site cd0...
  2. putative active si...
  3. putative Ca bindin...

Protein sequence

>MCA_02685_1
MYLSQSSQHSDPGALSQKAFPTFSSMQPQCSSTGPPSPSIQQQKNSSNTELQQGTLDLPDIKPIKHASTFPLTTQSLSSP
SSHSPKSAAFKHSKSQYFAASSNSPSSSHHHQLVSSILSTLFPSSGSSSTSQSNSSSRSSFSIKSILRSKMKPEDQPTNS
FNVKPKTSPTSPKSSRSSRLSLSGSQAFFRSLSPSRLSGSSRSRSRSPSRSQLPMGPSLANAVVDGTDNSLASNFEYQET
PKRFLSKELRSRTEPITFMFSRRPTVRKKGKKVRHLSLPGNNAPSIDGAANNQTSNSFPSTENAGHFPAAATSNDNKAGT
TIATTTNPQCPHLPQNELQPPASNLHTTGEHANDFSAPVSFTNPFPSPTTPTIMTTNELNHQQPLIHLQDATLCLPSVLQ
KGIPMFRVTHKKKTLRNIQVQPINDTFVLSWDEKASSKFDIDDITGIHVGNKACYYQNELYKGNIIPDEYNRWITIIYTG
TSKKKIRELHVVAQNENDFNLLVQTVQSLWNFRQSCDNLLELDELALKSEWDLLNMQEVPYAQIEQVLAKHDIYCSPKQL
REIHKRIISSNKESFNFQEFKLLLEALNERPEISKIWEDRCDMTEPLGMSFSAFKRFCKHVQKLKLSKEEKFELFQKYSE
GNDSIDARQFKNFLVSEEDNPAMTVIPQDLSFKLTDYFISSSHNTYLLDRQVFGYSSAEPYVRALLDNCRCVEIDIWDGD
SEPVVSHGRTMTSDVKFQTVIMAINEYAFQESKLPLILSFEVHCSPDNQKKMVEIMKSIFKDKLVTEPLHRNSFTLPTPE
ELMEKILIKVKPASLTSEYKMLGQAIGEHTQEEEEDSSSDSGENGSSPVPVVEATSGISRLGIRRKSKSGAQATKDSKII
PMLGELGVYLSGTKYRGFTTAAAKKPNHCFSFNEAKINEMICASDSEDEGLEDQFINHNKRYFSRMYPHNLRITSKNYDP
IPYWRRGAQMVALNWQNYDTAMQLNDAMFAGTQGWVLKPKVEETVHRRLTIDIISLVHFPKLNKLTRNVAGATSVSSTIT
TTTVTENSPSKNGLSVPSTSGSPNGTTKTNTVSSITQTQTITNSQFSISVELFGCVEKKDSLKTSALKYLAGSPNKGHAE
SVSRKDIWYSSPLTTSTIHTHTTRYNQTSISTNHFSATQSSTTSAVSGLPPVSNAPNLAHNINTTGGYHHYNNTPYTNCN
CFMAHADTKGCFIDEEGNKTYTSGNQFSREVSAKDYDFAFVRFSVRDSADSGQPVALYMVRLKNLNQGYRQLPLRDLEEG
EFKSAKLFVKIKLEDI

GO term prediction

Biological Process

GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction

Molecular Function

GO:0004435 phosphatidylinositol phospholipase C activity
GO:0008081 phosphoric diester hydrolase activity

Cellular Component

None predicted.