Protein

MIA_00253_1

Length
545 amino acids

Browser: contig01:713812-715450-

Protein function

EGGNOG:0PGHMDHH1ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1 S DNA- damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity)
SGD closest match:S000002319DHH1ATP-dependent RNA helicase DHH1
CGD closest match:CAL0000182112DHH1ATP-dependent RNA helicase DHH1

Protein alignments

%idAln lengthE-value
MCA_01622_194.159%4280.0MCA_01622_1
A0A0J9XIF7_GEOCN89.835%4230.0Similar to Saccharomyces cerevisiae YDL160C DHH1 Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping OS=Geotrichum candidum GN=BN980_GECA19s00395g PE=3 SV=1
A0A060T2K6_BLAAD89.573%4220.0ARAD1C26004p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C26004g PE=3 SV=1
A0A167CT65_9ASCO87.972%4240.0DExD/H-box ATP-dependent RNA helicase DHH1 OS=Sugiyamaella lignohabitans GN=DHH1 PE=3 SV=1
A0A1E3PR31_9ASCO86.223%4210.0Putative DEAD-box RNA helicase Dhh1/Vad1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48421 PE=3 SV=1
DHH1_YARLI84.834%4220.0ATP-dependent RNA helicase DHH1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=DHH1 PE=3 SV=1
UniRef50_A0A0G2GY8079.433%4230.0Putative dna repair protein rad18 n=1 Tax=Phaeomoniella chlamydospora TaxID=158046 RepID=A0A0G2GY80_9EURO
DHH1_CANAL79.905%4230.0ATP-dependent RNA helicase DHH1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DHH1 PE=3 SV=1
DHH1_YEAST79.808%4160.0ATP-dependent RNA helicase DHH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DHH1 PE=1 SV=1
A0A1E4TCP8_9ASCO77.616%4110.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_140291 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0448

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 400 450 500 545

Detailed signature matches

  1. Domain IPR014014
    RNA helicase, DEAD-box type, Q motif
    1. PS51195 (Q_MOTIF)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  6. SITE IPR000629
    ATP-dependent RNA helicase DEAD-box, conserved site
    1. PS00039 (DEAD_ATP_H...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd00079 (HELICc)
  3. cd00268 (DEADc)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. Mg++ binding site ...
  3. motif III cd00268
  4. nucleotide binding...
  5. ATP-binding site c...

Protein sequence

>MIA_00253_1
MASNPTSSQDALSLAPNSNNNDWRSSLNIPAKDTRPQTEDVTNTKGNGFEDFYLKRELLMGIFEAGFEKPSPIQEEAIPI
ALAGRDILARAKNGTGKTAAFVIPALQQVNTKINKIQALILVPTRELALQTSQVCKTLGKHLGIQVMATTGGTNLKDDIL
RLNETVHVLVGTPGRVLDFAGKQVIDFSECPMFIMDEADKLLSPEFTPVVEQLLGYFPASRQILLFSATFPLVVKSFMDK
HLNKPYEINLMDELTLRGITQYYAFVEEKQKLHCLNTLFSKLQINQSIIFCNSTNRVELLARKITELGYSCYYSHAKMQQ
QNRNRVFHEFRNGNCRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRFGHLGLAINLISWNDRFSLYKIE
QELGTEIKPIPAHIDTSLYVADAVENIPKPFPITELPRDSSTSRVNGNNQRYNNNNNNRNQQDHQIYQQQQQQQQQFSQI
PSQQYPYMPQQYAPLQQQQQQPQQQQISGNFYNNAQGNNYPNYPPRPAFMQAPPPQQAAYYSQQR

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.