Protein

MIA_00250_1

Length
328 amino acids

Browser: contig01:705815-706802-

Protein function

EGGNOG:0PIJ0TSC10)-reductase
SGD closest match:S000000469TSC103-ketodihydrosphingosine reductase TSC10
CGD closest match:CAL0000189000KSR13-ketodihydrosphingosine reductase TSC10

Protein alignments

%idAln lengthE-value
MCA_04639_162.179%3125.42e-142MCA_04639_1
A0A0J9X7G8_GEOCN64.570%3023.29e-139Similar to Saccharomyces cerevisiae YBR265W TSC10 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis OS=Geotrichum candidum GN=BN980_GECA05s01231g PE=4 SV=1
UniRef50_A0A0J9X7G864.570%3026.74e-136Similar to Saccharomyces cerevisiae YBR265W TSC10 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9X7G8_GEOCN
A0A1E3PIS8_9ASCO49.662%2963.62e-1063-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51908 PE=4 SV=1
A0A060T9B3_BLAAD50.694%2889.03e-104ARAD1C42944p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C42944g PE=4 SV=1
A0A161HHA5_9ASCO46.512%3011.12e-993-dehydrosphinganine reductase OS=Sugiyamaella lignohabitans GN=TSC10 PE=4 SV=1
TSC10_YARLI42.517%2942.52e-803-ketodihydrosphingosine reductase TSC10 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TSC10 PE=3 SV=1
TSC10_CANAL42.208%3089.54e-733-ketodihydrosphingosine reductase TSC10 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KSR1 PE=3 SV=2
A0A1E4THQ5_9ASCO42.308%2862.90e-66Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_122487 PE=4 SV=1
TSC10_YEAST29.595%3214.31e-413-ketodihydrosphingosine reductase TSC10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TSC10 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4673
Predicted cleavage: 32

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 328

Detailed signature matches

  1. Family IPR002347
    Short-chain dehydrogenase/reductase SDR
    1. PR00081 (GDHRDH)
    2. PF00106 (adh_short)
  2. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:3.40.50...
  3. NON_CYTOPLASM... (N...)
  4. TMhelix
  5. TRANSMEMBRANE (Tran...)
  6. cd08939 (KDSR-like_...)

Residue annotation

  1. putative NAD(P) bi...
  2. homotetramer inter...
  3. active site cd08939
  4. homodimer interfac...

Protein sequence

>MIA_00250_1
MGWFSGNYNLRHKLVVISGGSQGLGASIARLCVERGANVYIVARTERKLQNVVKSLKDVISEPDQIVGYVAADLSKQSEC
ARVYEEIGQPPDIVMCVAGLSLPGLLLEVPPEAFEISIDCIYKSSLYFSVEALRVMSKAPKSTEPRHITLFSSVVAFLGF
IGYGSYSPLKQAVRGLADVLRQEAIPFNVKVECVFPGNIDTEGFENEEKTKPEITKQIEGPSDIMNPDKCAELVLSRLDS
GQQMVHTDAIGWVLNGLMLGSSPRTHGVFLTLTGFILSLVIPIWNLIVNNQIKTYFKKREQLADFINNDEDEEGEELEQE
SSTNQLLN

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.