Protein
MCA_04639_1
Length
323 amino acids
Gene name: TSC10
Description: 3-ketodihydrosphingosine reductase TSC10
Browser: contigC:3575414-3576386-
RNA-seq: read pairs 1012, FPKM 38.6, percentile rank 59.5% (100% = highest expression)
Protein function
| Annotation: | TSC10 | 3-ketodihydrosphingosine reductase TSC10 | |
|---|---|---|---|
| KEGG: | K04708 | E1.1.1.102 | 3-dehydrosphinganine reductase [EC:1.1.1.102] |
| EGGNOG: | 0PIJ0 | TSC10 | )-reductase |
| SGD closest match: | S000000469 | TSC10 | 3-ketodihydrosphingosine reductase TSC10 |
| CGD closest match: | CAL0000189000 | KSR1 | 3-ketodihydrosphingosine reductase TSC10 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A0J9X7G8_GEOCN | 67.19% | 320 | 1e-117 | Similar to Saccharomyces cerevisiae YBR265W TSC10 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis OS=Geotrichum candidum GN=BN980_GECA05s01231g PE=4 SV=1 |
| UniRef50_A0A0J9X7G8 | 67.19% | 320 | 2e-114 | Similar to Saccharomyces cerevisiae YBR265W TSC10 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9X7G8_GEOCN |
| MIA_00250_1 | 62.18% | 312 | 4e-111 | MIA_00250_1 |
| A0A1E3PIS8_9ASCO | 51.96% | 306 | 1e-84 | 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51908 PE=4 SV=1 |
| A0A161HHA5_9ASCO | 48.28% | 319 | 2e-75 | 3-dehydrosphinganine reductase OS=Sugiyamaella lignohabitans GN=TSC10 PE=4 SV=1 |
| A0A060T9B3_BLAAD | 49.67% | 300 | 4e-74 | ARAD1C42944p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C42944g PE=4 SV=1 |
| TSC10_YARLI | 40.33% | 305 | 2e-52 | 3-ketodihydrosphingosine reductase TSC10 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TSC10 PE=3 SV=1 |
| A0A1E4THQ5_9ASCO | 42.38% | 269 | 6e-47 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_122487 PE=4 SV=1 |
| TSC10_CANAL | 42.70% | 274 | 1e-43 | 3-ketodihydrosphingosine reductase TSC10 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KSR1 PE=3 SV=2 |
| TSC10_YEAST | 32.68% | 257 | 7e-30 | 3-ketodihydrosphingosine reductase TSC10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TSC10 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0031
Protein family membership
- Short-chain dehydrogenase/reductase SDR (IPR002347)
Domains and repeats
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Domain
1
50
100
150
200
250
323
Detailed signature matches
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SSF51735 (NAD(P)-bi...)
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no IPR
Unintegrated signatures
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CYTOPLASMIC_D... (C...)
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-
NON_CYTOPLASM... (N...)
-
-
TRANSMEMBRANE (Tran...)
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cd08939 (KDSR-like_...)
Residue annotation
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putative NAD(P) bi...
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homotetramer inter...
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active site cd08939
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homodimer interfac...
Protein sequence
>MCA_04639_1 MGWYSDYYHVKDKLIVISGGSQGLGASLAKACSKHGASVYVVARTESKLIKVVDSCRELAVSPETQKFGYVSADLSDFKQ CKKVFAEIYQKENKTPDMVMCAAGLAIPGLLVDATEEVLETSIDCIYKSCLYFSLAALQAMAKDPLNGTITKQSRRHITL FSSVVAFYSFIGYGSYGPLKAAIRSLADVLRQECIAYDIKVECVFPGNIGTEGFEIEEKTKPEITKIIEGPSDVMDPDAC AELILKRLDMGYQMVHTDFIGWVLNGISLGASPRTSSILLTLVSLILTLFVPIWDMIVNFQIKSYFQKKAQIEPIDIKEK KEN
GO term prediction
Biological Process
None predicted.
Molecular Function
None predicted.
Cellular Component
None predicted.