MIA_00230_1

Protein

Length

1,564 amino acids

Protein function

EGGNOG:	0QDVE	PAN1	Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity)
SGD closest match:	S000001445	PAN1	Actin cytoskeleton-regulatory complex protein PAN1
CGD closest match:	CAL0000184200	PAN1	Actin cytoskeleton-regulatory complex protein PAN1

Protein alignments

	%id	Aln length	E-value
MCA_00886_1	64.345%	962	0.0	MCA_00886_1
A0A0J9YHG9_GEOCN	54.279%	888	0.0	Similar to Saccharomyces cerevisiae YIR006C PAN1 Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p OS=Geotrichum candidum GN=BN980_GECA01s04256g PE=4 SV=1
UniRef50_A0A0J9YHG9	54.279%	888	0.0	Similar to Saccharomyces cerevisiae YIR006C PAN1 Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9YHG9_GEOCN
A0A060SZL0_BLAAD	53.944%	862	0.0	ARAD1C01518p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C01518g PE=4 SV=1
A0A167FLQ2_9ASCO	50.850%	824	0.0	Ede1p OS=Sugiyamaella lignohabitans GN=EDE1 PE=4 SV=1
PAN1_YARLI	47.413%	947	0.0	Actin cytoskeleton-regulatory complex protein PAN1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PAN1 PE=3 SV=1
A0A1E3PHK9_9ASCO	44.023%	1029	0.0	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51502 PE=4 SV=1
A0A1E4TGM5_9ASCO	42.538%	851	1.14e-165	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2639 PE=4 SV=1
PAN1_CANAL	35.736%	999	5.01e-139	Actin cytoskeleton-regulatory complex protein PAN1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PAN1 PE=3 SV=2
PAN1_YEAST	33.704%	899	6.91e-92	Actin cytoskeleton-regulatory complex protein PAN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAN1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0174

Protein family membership

None predicted.

Domains and repeats

Domain
137 - 239
EF-hand domain pair (IPR011992)
EF-hand domain (IPR002048)
EH domain (IPR000261)
461 - 559
EF-hand domain pair (IPR011992)
EF-hand domain (IPR002048)
EH domain (IPR000261)
1,542 - 1,559
WH2 domain (IPR003124)

1 200 400 600 800 1000 1200 1400 1564

Detailed signature matches

IPR011992

EF-hand domain pair
1. SSF47473 (EF-hand)
  
  461 - 556
  
  SUPERFAMILY
  SSF47473 (EF-hand)
  
  137 - 238
  
  SUPERFAMILY
  SSF47473 (EF-hand)
IPR000261

EH domain
1. SM00027 (eh_3)
  
  144 - 239
  
  SMART
  SM00027 (eh_3)
  
  463 - 558
  
  SMART
  SM00027 (eh_3)
2. PF12763 (EF-hand_4)
  
  158 - 233
  
  Pfam
  PF12763 (EF-hand_4)
  
  468 - 559
  
  Pfam
  PF12763 (EF-hand_4)
3. PS50031 (EH)
  
  470 - 559
  
  PROSITE profiles
  PS50031 (EH)
  
  151 - 233
  
  PROSITE profiles
  PS50031 (EH)
IPR002048

EF-hand domain
1. PS50222 (EF_HAND_2)
  
  503 - 538
  
  PROSITE profiles
  PS50222 (EF_HAND_2)
  
  184 - 219
  
  PROSITE profiles
  PS50222 (EF_HAND_2)
IPR003124

WH2 domain
1. PS51082 (WH2)
  
  1,542 - 1,559
  
  PROSITE profiles
  PS51082 (WH2)

no IPR

Unintegrated signatures

Coil

1,096 - 1,123

COILS
Coil (Coil)

724 - 751

COILS
Coil (Coil)

816 - 836

COILS
Coil (Coil)

1,064 - 1,091

COILS
Coil (Coil)
G3DSA:1.10.23...

10 - 242

GENE3D
G3DSA:1.10.238.10 (G3DSA:1.10.238.10)

443 - 559

GENE3D
G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
G3DSA:1.20.10...

560 - 1,126

GENE3D
G3DSA:1.20.1000.10 (G3DSA:1.20.1000.10)
cd00052 (EH)

155 - 221

CDD
cd00052 (EH)

474 - 540

CDD
cd00052 (EH)
mobidb-lite (disord...)

247 - 278

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 34

MobiDB Lite
mobidb-lite (disorder_prediction)

965 - 1,340

MobiDB Lite
mobidb-lite (disorder_prediction)

885 - 938

MobiDB Lite
mobidb-lite (disorder_prediction)

613 - 633

MobiDB Lite
mobidb-lite (disorder_prediction)

1,398 - 1,546

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

pseudo EF-hand loo...

161S

pseudo EF-hand loop
161S, 162K, 163L, 170L, 171P, 172G, 173S, 174V
CDD
cd00052 (EH)

162K

pseudo EF-hand loop
161S, 162K, 163L, 170L, 171P, 172G, 173S, 174V
CDD
cd00052 (EH)

163L

pseudo EF-hand loop
161S, 162K, 163L, 170L, 171P, 172G, 173S, 174V
CDD
cd00052 (EH)

170L

pseudo EF-hand loop
161S, 162K, 163L, 170L, 171P, 172G, 173S, 174V
CDD
cd00052 (EH)

171P

pseudo EF-hand loop
161S, 162K, 163L, 170L, 171P, 172G, 173S, 174V
CDD
cd00052 (EH)

172G

pseudo EF-hand loop
161S, 162K, 163L, 170L, 171P, 172G, 173S, 174V
CDD
cd00052 (EH)

173S

pseudo EF-hand loop
161S, 162K, 163L, 170L, 171P, 172G, 173S, 174V
CDD
cd00052 (EH)

174V

pseudo EF-hand loop
161S, 162K, 163L, 170L, 171P, 172G, 173S, 174V
CDD
cd00052 (EH)
peptide binding po...

179L

peptide binding pocket
179L, 189L, 193W
CDD
cd00052 (EH)

189L

peptide binding pocket
179L, 189L, 193W
CDD
cd00052 (EH)

193W

peptide binding pocket
179L, 189L, 193W
CDD
cd00052 (EH)
Ca2+ binding site ...

197D

Ca2+ binding site
197D, 199T, 201S, 208E
CDD
cd00052 (EH)

199T

Ca2+ binding site
197D, 199T, 201S, 208E
CDD
cd00052 (EH)

201S

Ca2+ binding site
197D, 199T, 201S, 208E
CDD
cd00052 (EH)

208E

Ca2+ binding site
197D, 199T, 201S, 208E
CDD
cd00052 (EH)
pseudo EF-hand loo...

480E

pseudo EF-hand loop
480E, 481W, 482D, 489I, 490T, 491G, 492D, 493M
CDD
cd00052 (EH)

481W

pseudo EF-hand loop
480E, 481W, 482D, 489I, 490T, 491G, 492D, 493M
CDD
cd00052 (EH)

482D

pseudo EF-hand loop
480E, 481W, 482D, 489I, 490T, 491G, 492D, 493M
CDD
cd00052 (EH)

489I

pseudo EF-hand loop
480E, 481W, 482D, 489I, 490T, 491G, 492D, 493M
CDD
cd00052 (EH)

490T

pseudo EF-hand loop
480E, 481W, 482D, 489I, 490T, 491G, 492D, 493M
CDD
cd00052 (EH)

491G

pseudo EF-hand loop
480E, 481W, 482D, 489I, 490T, 491G, 492D, 493M
CDD
cd00052 (EH)

492D

pseudo EF-hand loop
480E, 481W, 482D, 489I, 490T, 491G, 492D, 493M
CDD
cd00052 (EH)

493M

pseudo EF-hand loop
480E, 481W, 482D, 489I, 490T, 491G, 492D, 493M
CDD
cd00052 (EH)
peptide binding po...

498F

peptide binding pocket
498F, 508L, 512W
CDD
cd00052 (EH)

508L

peptide binding pocket
498F, 508L, 512W
CDD
cd00052 (EH)

512W

peptide binding pocket
498F, 508L, 512W
CDD
cd00052 (EH)
Ca2+ binding site ...

516D

Ca2+ binding site
516D, 518G, 520K, 527E
CDD
cd00052 (EH)

518G

Ca2+ binding site
516D, 518G, 520K, 527E
CDD
cd00052 (EH)

520K

Ca2+ binding site
516D, 518G, 520K, 527E
CDD
cd00052 (EH)

527E

Ca2+ binding site
516D, 518G, 520K, 527E
CDD
cd00052 (EH)

Protein sequence

>MIA_00230_1
MYNYPGQGYPLQQQQTGSANSYYQQQQQQQPYQTGLAPQATGYIQPQATGYVQPQATGYVQPQATGYVQPQATGYVQPQA
TGYVQPQATGYIQSYGTATTPAVPPLPQITTQSFQLTGTPALASSSSTSSTPSSTSVKIPNVRLSFITADDQRNFETLFR
SKLGPGEQALPGSVAKDILMLSNLSPTQLSNIWILSDTTKSGQLLFPEFALAMYLCSLALKGNPLPTKLPDHIKNEVSSL
VDIIAFSTPDAKPPPPPSNVPQFGSTSTTTSQPQQSSSLNTLMSLQQALPTGLQSQPTGGFIAPQATGYTSALQPQTTGY
TSALTAQSTGYTPALTAQTTGYAPALTAQTTGYTPALTAQTTGYTPALTAQTTGYTPALQAQTTGYAPLQAQSTGYTPLQ
SQATGYQIAPLTAMPTGRPGEWGFINTPTGGLPGMDAFRSRFMPQQGVQNFTPSELQGNAQVEWAITKEEKRIYDGIFSE
WDKERKGFITGDMGISIFSQSGLNRGDLEAIWTLSDPGNKGKLDRDEFAVAMHLIYRHLNGYPIPARLPPELIPPSSQNF
SDSVDTIKSYLKQSSKPNTVSYLKSHSLKSSAPAFKKDATVFKNNDDDFGYVSKSRHRSKRDAANEDPDEKHLTSEKLSI
AQLRKLVHEKQIILDAIDAKDEEEFDAVQDIQTRDLNVIDELKHRITNIQNEINNNPDAPLLAGDPHERKKELLRQLNKN
ADALPQITNDVRKVEDEIVRLKLELFRLKTEKEHPGSTIIGTGPNGTITEADRRKARNRAIMKARLAAVTGNAADAEGGN
KFEEFETKFFQESENIRKERETNEKLFRDIEDSTAQIKRDLELSLRETRDDIHTDRERLRWEEAIGVEDEVKDFIYSLRR
SATNNNNTAASSSSFGSSFGSSTTAASSSFSPSSSTSSLPAASSSSAQNNTKRSASERAAYIKAEAERRMNEKLAALGIS
RPNKAASAFQAPTSSSPSPSPAPATAPVAPVSEKKASPPPPPPPHSKPAAPAAPAFTAAPTPPVAPAAPTSRSFAPAAPA
APAAPATTDDDSSSSDDDLDDAEFQELQRLKKQEEERLRKLEDEKKARDAKKAAKAHKKAERLASLKAEMEAMKERERKL
MADASDSDDDKPAPRAAPTSVAHPTAATLSPSTIGSTTTSTATPDTSSSSSLPEQNGADLHASNPFYRNTPAPAPTTAVP
ASTTTPSHHDNNPFFKPQQQQPKAPEPVPAAAPAAPAAPAAPAAPPFNPRSTTPKAPEPGIDKDTAANQRANQRGQSAYD
DGWGAESSSESSDDEDSSTRGGPDPSKLASMLFRSMAPQRPLGAQPTGQQSTPAAATAPAVPAVPAVPAAPAAPVVQAEP
VTPAPQAVPVAPVAPAPEVVPAAPAVAEIPTVIAAPAQIPPAPPVQPFPTQPATADSVSNSSNSSYNTPDLEATQPAFAA
PPPPTDLAPPPPPVPETQPQFSAPPPPPLPEVAAPPPPPLPQVAAPSPPPLAPPPPPAGVAPPPPPPLPTGTAAPVGAPP
PPPPPAILLDDSLETSSRPDFAGSGLLDAIQRGTTLRKVANPPK

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_00230_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component