MCA_00886_1

Protein

Length

1,515 amino acids

Gene name: PAN1

Description: Actin cytoskeleton-regulatory complex protein PAN1

Browser: contigA:2790282-2795000-

RNA-seq: read pairs 8721, FPKM 71.1, percentile rank 73.0% (100% = highest expression)

Protein function

Annotation:		PAN1	Actin cytoskeleton-regulatory complex protein PAN1
KEGG:	K20047	PAN1	actin cytoskeleton-regulatory complex protein PAN1
EGGNOG:	0QDVE	PAN1	Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity)
SGD closest match:	S000001445	PAN1	Actin cytoskeleton-regulatory complex protein PAN1
CGD closest match:	CAL0000184200	PAN1	Actin cytoskeleton-regulatory complex protein PAN1

Protein alignments

	%id	Aln length	E-value
MIA_00230_1	63.51%	940	0.0	MIA_00230_1
A0A0J9YHG9_GEOCN	52.86%	893	0.0	Similar to Saccharomyces cerevisiae YIR006C PAN1 Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p OS=Geotrichum candidum GN=BN980_GECA01s04256g PE=4 SV=1
UniRef50_A0A0J9YHG9	52.86%	893	0.0	Similar to Saccharomyces cerevisiae YIR006C PAN1 Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9YHG9_GEOCN
A0A060SZL0_BLAAD	52.38%	861	0.0	ARAD1C01518p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C01518g PE=4 SV=1
PAN1_YARLI	46.15%	923	0.0	Actin cytoskeleton-regulatory complex protein PAN1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PAN1 PE=3 SV=1
A0A167FLQ2_9ASCO	50.00%	840	0.0	Ede1p OS=Sugiyamaella lignohabitans GN=EDE1 PE=4 SV=1
A0A1E3PHK9_9ASCO	48.53%	886	0.0	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51502 PE=4 SV=1
A0A1E4TGM5_9ASCO	42.42%	844	6e-148	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2639 PE=4 SV=1
PAN1_CANAL	38.10%	895	3e-133	Actin cytoskeleton-regulatory complex protein PAN1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PAN1 PE=3 SV=2
PAN1_YEAST	34.17%	872	8e-86	Actin cytoskeleton-regulatory complex protein PAN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAN1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0037

Protein family membership

None predicted.

Domains and repeats

Domain
5 - 69
Domain of unknown function DUF1720 (IPR013182)
137 - 238
EF-hand domain pair (IPR011992)
EF-hand domain (IPR002048)
EH domain (IPR000261)
464 - 562
EF-hand domain pair (IPR011992)
EF-hand domain (IPR002048)
EH domain (IPR000261)

1 200 400 600 800 1000 1200 1400 1515

Detailed signature matches

IPR013182

Domain of unknown function DUF1720
1. PF08226 (DUF1720)
  
  5 - 69
  
  Pfam
  PF08226 (DUF1720)
IPR011992

EF-hand domain pair
1. SSF47473 (EF-hand)
  
  464 - 559
  
  SUPERFAMILY
  SSF47473 (EF-hand)
  
  137 - 237
  
  SUPERFAMILY
  SSF47473 (EF-hand)
IPR000261

EH domain
1. SM00027 (eh_3)
  
  143 - 238
  
  SMART
  SM00027 (eh_3)
  
  466 - 561
  
  SMART
  SM00027 (eh_3)
2. PF12763 (EF-hand_4)
  
  472 - 562
  
  Pfam
  PF12763 (EF-hand_4)
  
  155 - 232
  
  Pfam
  PF12763 (EF-hand_4)
3. PS50031 (EH)
  
  150 - 229
  
  PROSITE profiles
  PS50031 (EH)
  
  473 - 562
  
  PROSITE profiles
  PS50031 (EH)
IPR002048

EF-hand domain
1. PS50222 (EF_HAND_2)
  
  506 - 541
  
  PROSITE profiles
  PS50222 (EF_HAND_2)
  
  183 - 218
  
  PROSITE profiles
  PS50222 (EF_HAND_2)

no IPR

Unintegrated signatures

Coil

1,073 - 1,139

COILS
Coil (Coil)

729 - 756

COILS
Coil (Coil)
G3DSA:1.10.23...

10 - 241

GENE3D
G3DSA:1.10.238.10 (G3DSA:1.10.238.10)

452 - 564

GENE3D
G3DSA:1.10.238.10 (G3DSA:1.10.238.10)
G3DSA:1.20.10...

917 - 1,154

GENE3D
G3DSA:1.20.1000.10 (G3DSA:1.20.1000.10)
cd00052 (EH)

154 - 220

CDD
cd00052 (EH)

477 - 543

CDD
cd00052 (EH)
mobidb-lite (disord...)

619 - 639

MobiDB Lite
mobidb-lite (disorder_prediction)

886 - 1,515

MobiDB Lite
mobidb-lite (disorder_prediction)

64 - 131

MobiDB Lite
mobidb-lite (disorder_prediction)

254 - 291

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 37

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

pseudo EF-hand loo...

160S

pseudo EF-hand loop
160S, 161K, 162L, 169L, 170S, 171G, 172E, 173S
CDD
cd00052 (EH)

161K

pseudo EF-hand loop
160S, 161K, 162L, 169L, 170S, 171G, 172E, 173S
CDD
cd00052 (EH)

162L

pseudo EF-hand loop
160S, 161K, 162L, 169L, 170S, 171G, 172E, 173S
CDD
cd00052 (EH)

169L

pseudo EF-hand loop
160S, 161K, 162L, 169L, 170S, 171G, 172E, 173S
CDD
cd00052 (EH)

170S

pseudo EF-hand loop
160S, 161K, 162L, 169L, 170S, 171G, 172E, 173S
CDD
cd00052 (EH)

171G

pseudo EF-hand loop
160S, 161K, 162L, 169L, 170S, 171G, 172E, 173S
CDD
cd00052 (EH)

172E

pseudo EF-hand loop
160S, 161K, 162L, 169L, 170S, 171G, 172E, 173S
CDD
cd00052 (EH)

173S

pseudo EF-hand loop
160S, 161K, 162L, 169L, 170S, 171G, 172E, 173S
CDD
cd00052 (EH)
peptide binding po...

178L

peptide binding pocket
178L, 188L, 192W
CDD
cd00052 (EH)

188L

peptide binding pocket
178L, 188L, 192W
CDD
cd00052 (EH)

192W

peptide binding pocket
178L, 188L, 192W
CDD
cd00052 (EH)
Ca2+ binding site ...

196D

Ca2+ binding site
196D, 198T, 200A, 207E
CDD
cd00052 (EH)

198T

Ca2+ binding site
196D, 198T, 200A, 207E
CDD
cd00052 (EH)

200A

Ca2+ binding site
196D, 198T, 200A, 207E
CDD
cd00052 (EH)

207E

Ca2+ binding site
196D, 198T, 200A, 207E
CDD
cd00052 (EH)
pseudo EF-hand loo...

483Q

pseudo EF-hand loop
483Q, 484W, 485D, 492I, 493T, 494G, 495E, 496M
CDD
cd00052 (EH)

484W

pseudo EF-hand loop
483Q, 484W, 485D, 492I, 493T, 494G, 495E, 496M
CDD
cd00052 (EH)

485D

pseudo EF-hand loop
483Q, 484W, 485D, 492I, 493T, 494G, 495E, 496M
CDD
cd00052 (EH)

492I

pseudo EF-hand loop
483Q, 484W, 485D, 492I, 493T, 494G, 495E, 496M
CDD
cd00052 (EH)

493T

pseudo EF-hand loop
483Q, 484W, 485D, 492I, 493T, 494G, 495E, 496M
CDD
cd00052 (EH)

494G

pseudo EF-hand loop
483Q, 484W, 485D, 492I, 493T, 494G, 495E, 496M
CDD
cd00052 (EH)

495E

pseudo EF-hand loop
483Q, 484W, 485D, 492I, 493T, 494G, 495E, 496M
CDD
cd00052 (EH)

496M

pseudo EF-hand loop
483Q, 484W, 485D, 492I, 493T, 494G, 495E, 496M
CDD
cd00052 (EH)
peptide binding po...

501F

peptide binding pocket
501F, 511L, 515W
CDD
cd00052 (EH)

511L

peptide binding pocket
501F, 511L, 515W
CDD
cd00052 (EH)

515W

peptide binding pocket
501F, 511L, 515W
CDD
cd00052 (EH)
Ca2+ binding site ...

519D

Ca2+ binding site
519D, 521G, 523K, 530E
CDD
cd00052 (EH)

521G

Ca2+ binding site
519D, 521G, 523K, 530E
CDD
cd00052 (EH)

523K

Ca2+ binding site
519D, 521G, 523K, 530E
CDD
cd00052 (EH)

530E

Ca2+ binding site
519D, 521G, 523K, 530E
CDD
cd00052 (EH)

Protein sequence

>MCA_00886_1
MYNYQGQGVPLQQQQTFYQPPQQQQQQTGYAQPQQTGYVQPQQTGYIQSQYQIQPQATGYIQPQPTTGYLQSQQTGYLQQ
QPQQYSNSVGSLPPVPPIPQSYQQPTNGSSGSLASAQPTGSSTPAPLSATTTGASVKIPNIRLSFITADDQRQFETLFRS
KLAPGEIALSGESARDLLMLSNLPADTLSEIWMLSDTTKAGKLLFPEFALAMYLCSLALKGNSIPKTLPEVIKNEVSSLV
DIISFSAADNDPLPPNVPSFSYSGSNNNNANNTTTTTNNTSSTSNKPAQESSLNTLIGLQQSMATGSQPLQAQRTGGFIQ
PQGTGYQPALPAQSTGYQPMQAQLTGYQPALQNQSTGYQPVQAQSTGYQPVQAQSTGYQPIQAQSTGYQPIQAQTTGYQP
LQSQSTGYQVAPLTAMPTGRPGQWGFINTPTGGLPGLDTFQSAFMPTTQGPIPQDTSAIKGNAKVEWAISKEEKRIFDGI
FSQWDTENKGYITGEMGIQIFSMSGLNRQDLEAIWTLCDPGNKGKLDRDEFAVAMHLIYRHVNGYPIPSRLPPELIPPSS
QNFSDSVNTIKSYLKSSSSSNSSSNVSYLKNHSLKSSAPVFKKDATVFKNNDDDFGYVSKARHRSKKDDSSSKDDSHIST
DSMSIAQLKKLVHEKQILLDAIDAKDEDDYDAAQDIEYRDKKIIEELKNRIINIQKEINQHPDAPLLESDPHEQKKELSR
ALAKQFDALPQITNDVRKIEDEIASAKLELFRLQAEKEHPGSTIVGTGPNGTITEADRRKAKSKALLKARMAALTGSAAP
ASDNDFEEFESKLFQESEAIRKERESHERMFRDIEDSASQIKRDLEMTLRESRDDIHSDREKLRWEEAIGVEDEVKDLIY
SLRHMKMDNSSRQTSSSFSSSTFSSKKDSKPELFTSSSTSSLDKTNSSSTAAAGKRSASERSAYIKAEAERRMNERLSAL
GLSRPSKSSAFTAPINNESSSSLSSSSSSVPKKAPPPPPPKKGSKVSSSPKPVASPSASTTSVNNTPSAPIPEPPKSVPE
PPKSVSPAPPQPVEKEEDSDSSSSDDDMDDEEFRQLQKLKAQEEARLKKLEEEKKAKEEKKAAKAKKKAERMASLRAEME
AMKERERRLLAEASESDDEKKQPAQEEKKPEPVKPVEEEPKKSVEEESSSTTTVEEKSESHSTNPFFRGGAAATAAQASS
HNPFAKVNKPAETPAPEPVKPARTNPPPTKAPEPVIDRDAAASQRANQRGQSAYDDGWGAESSDESSDEDDDRPTRGAPD
PSKLASMLFRSMAPPQKPLSQQTTGRQTLASSAPAPPAVPAVPAVPAVPAEPAEPAASVPPVPVSAPEVQAPAPPAVPEA
PASEAPAPPSIPDFSAPSAPTGIPPPPPVPDFAAPPAPTGAPPPPPPPPPAPEFSAPAPPPPPPAAPAGEAPPVPNFAAP
PPPPPPPPAPDMSAPPPPPPAPSMGGAPPPPPPPPPPAASLLAASDDVSKPDFSGSGLLAEIESRPKLRKVNPPR

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005509 calcium ion binding
GO:0005515 protein binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MCA_00886_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component