MIA_00227_1

Protein

Length

337 amino acids

Protein function

EGGNOG:	0PFMM	PGUG_03741	Dehydrogenase
SGD closest match:	S000005218	GOR1	Glyoxylate reductase 1
CGD closest match:	CAL0000192040	GOR1	Glyoxylate reductase

Protein alignments

	%id	Aln length	E-value
MCA_02492_1	68.468%	333	2.89e-169	MCA_02492_1
A0A0J9XGB1_GEOCN	59.878%	329	6.72e-151	Similar to Saccharomyces cerevisiae YNL274C GOR1 Glyoxylate reductase OS=Geotrichum candidum GN=BN980_GECA15s00065g PE=3 SV=1
A0A161HGX6_9ASCO	57.879%	330	2.04e-138	Gor1p OS=Sugiyamaella lignohabitans GN=GOR1 PE=3 SV=1
A0A1D8PCW3_CANAL	53.779%	344	1.23e-131	Glyoxylate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GOR1 PE=3 SV=1
A0A060T1I7_BLAAD	58.735%	332	7.14e-128	ARAD1A00880p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A00880g PE=3 SV=1
UniRef50_A0A1L0BWU0	52.976%	336	1.62e-121	CIC11C00000002390 n=2 Tax=[Candida] intermedia TaxID=45354 RepID=A0A1L0BWU0_9ASCO
Q6C7U5_YARLI	55.015%	329	5.98e-121	YALI0D25256p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D25256g PE=3 SV=1
A0A1E4TAG1_9ASCO	56.098%	328	6.57e-119	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_28277 PE=3 SV=1
A0A1E3PJZ8_9ASCO	57.096%	303	1.89e-116	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_69982 PE=3 SV=1
GOR1_YEAST	48.673%	339	1.59e-106	Glyoxylate reductase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GOR1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0216

Protein family membership

None predicted.

Domains and repeats

Domain
25 - 330
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (IPR006139)
Domain
119 - 299
NAD(P)-binding domain (IPR016040)
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain (IPR006140)

1 50 100 150 200 250 300 337

Detailed signature matches

IPR006139

D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
1. PF00389 (2-Hacid_dh)
  
  25 - 330
  
  Pfam
  PF00389 (2-Hacid_dh)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  119 - 299
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR006140

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
1. PF02826 (2-Hacid_dh_C)
  
  125 - 299
  
  Pfam
  PF02826 (2-Hacid_dh_C)
IPR029752

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
1. PS00065 (D_2_HYDROX...)
  
  161 - 189
  
  PROSITE patterns
  PS00065 (D_2_HYDROXYACID_DH_1)
IPR029753

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
1. PS00671 (D_2_HYDROX...)
  
  239 - 255
  
  PROSITE patterns
  PS00671 (D_2_HYDROXYACID_DH_3)
2. PS00670 (D_2_HYDROX...)
  
  210 - 232
  
  PROSITE patterns
  PS00670 (D_2_HYDROXYACID_DH_2)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

4 - 126

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

127 - 300

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
SSF52283 (Formate/g...)

8 - 149

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)
cd12168 (Mand_dh_like)

8 - 325

CDD
cd12168 (Mand_dh_like)

Residue annotation

putative ligand bi...

62L

putative ligand binding site
62L, 90G, 91A, 92G, 115V, 250R, 297H
CDD
cd12168 (Mand_dh_like)

90G

putative ligand binding site
62L, 90G, 91A, 92G, 115V, 250R, 297H
CDD
cd12168 (Mand_dh_like)

91A

putative ligand binding site
62L, 90G, 91A, 92G, 115V, 250R, 297H
CDD
cd12168 (Mand_dh_like)

92G

putative ligand binding site
62L, 90G, 91A, 92G, 115V, 250R, 297H
CDD
cd12168 (Mand_dh_like)

115V

putative ligand binding site
62L, 90G, 91A, 92G, 115V, 250R, 297H
CDD
cd12168 (Mand_dh_like)

250R

putative ligand binding site
62L, 90G, 91A, 92G, 115V, 250R, 297H
CDD
cd12168 (Mand_dh_like)

297H

putative ligand binding site
62L, 90G, 91A, 92G, 115V, 250R, 297H
CDD
cd12168 (Mand_dh_like)
dimerization inter...

117P

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

118G

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

121D

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

125F

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

128L

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

129G

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

132R

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

134F

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

135S

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

144K

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

146W

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

149S

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

150V

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

154H

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

155D

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

156P

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

157Q

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

159K

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

175D

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

176R

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

179P

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

180L

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

276F

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

279E

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

280P

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

281E

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

287L

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

289N

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

292T

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

293L

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

294L

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

295L

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

296P

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

297H

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

298M

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

299G

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

302S

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

303Y

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

304E

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)

306R

dimerization interface
117P, 118G, 121D, 125F, 128L, 129G, 132R, 134F, 135S, 144K, 146W, 149S, 150V, 154H, 155D, 156P, 157Q, 159K, 175D, 176R, 179P, 180L, 276F, 279E, 280P, 281E, 287L, 289N, 292T, 293L, 294L, 295L, 296P, 297H, 298M, 299G, 302S, 303Y, 304E, 306R
CDD
cd12168 (Mand_dh_like)
NAD binding site c...

119T

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

166M

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

167G

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

168G

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

169I

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

189N

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

190R

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

220N

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

221V

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

222P

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

223L

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

224N

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

227T

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

248T

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

249A

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

250R

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

274D

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

297H

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

299G

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)

300T

NAD binding site
119T, 166M, 167G, 168G, 169I, 189N, 190R, 220N, 221V, 222P, 223L, 224N, 227T, 248T, 249A, 250R, 274D, 297H, 299G, 300T
CDD
cd12168 (Mand_dh_like)
catalytic site cd1...

250R

catalytic site
250R, 279E, 297H
CDD
cd12168 (Mand_dh_like)

279E

catalytic site
250R, 279E, 297H
CDD
cd12168 (Mand_dh_like)

297H

catalytic site
250R, 279E, 297H
CDD
cd12168 (Mand_dh_like)

Protein sequence

>MIA_00227_1
MSTATSPKPKILLLGEILHAQKEWQGLSDIAELVTAESKNRDEFIKDLSTKYSDITAIYRTLFSVGITGRFDHDLVEHFP
PSLKFVGHFGAGYDQIDVSALTDRGIQISNTPNAVVPGTADTNIFLVLGALRNFSFGQHQLRQKKWLASVELGHDPQGKV
LGILGMGGIGQAVRDRAVPLGFDKIIYYNRRRLPADLEKDSEYKPTIEELLAEADVISINVPLNNQTRHLINKNTIAQMK
DGVVIVNTARGPVINEQDLVDGLESGKIGAVGLDVFEHEPEINPGLLNNPKTLLLPHMGTHSYESRFDMENLVIKNIRSG
LTTGKLITLVPEQQSIF

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component