MCA_02492_1

Protein

Length

364 amino acids

Gene name: GOR1

Description: Glyoxylate reductase

Browser: contigB:1467887-1469063+

RNA-seq: read pairs 3980, FPKM 134.7, percentile rank 83.5% (100% = highest expression)

Protein function

Annotation:		GOR1	Glyoxylate reductase
EGGNOG:	0PFMM	PGUG_03741	Dehydrogenase
SGD closest match:	S000005218	GOR1	Glyoxylate reductase 1
CGD closest match:	CAL0000192040	GOR1	Glyoxylate reductase

Protein alignments

	%id	Aln length	E-value
MIA_00227_1	68.47%	333	1e-157	MIA_00227_1
A0A0J9XGB1_GEOCN	60.48%	334	2e-141	Similar to Saccharomyces cerevisiae YNL274C GOR1 Glyoxylate reductase OS=Geotrichum candidum GN=BN980_GECA15s00065g PE=3 SV=1
A0A161HGX6_9ASCO	54.22%	332	2e-123	Gor1p OS=Sugiyamaella lignohabitans GN=GOR1 PE=3 SV=1
Q6CDS0_YARLI	53.14%	350	7e-119	YALI0B21670p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B21670g PE=3 SV=1
UniRef50_Q6CDS0	53.14%	350	2e-115	YALI0B21670p n=7 Tax=Saccharomycetales TaxID=4892 RepID=Q6CDS0_YARLI
A0A060T1I7_BLAAD	56.12%	335	2e-118	ARAD1A00880p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A00880g PE=3 SV=1
A0A1D8PCW3_CANAL	51.03%	339	2e-117	Glyoxylate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GOR1 PE=3 SV=1
A0A1E4TAG1_9ASCO	54.85%	330	2e-107	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_28277 PE=3 SV=1
A0A1E3PJZ8_9ASCO	54.03%	298	2e-100	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_69982 PE=3 SV=1
GOR1_YEAST	47.62%	336	4e-99	Glyoxylate reductase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GOR1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9886
Predicted cleavage: 23

Protein family membership

None predicted.

Domains and repeats

Domain
44 - 354
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (IPR006139)
Domain
141 - 323
NAD(P)-binding domain (IPR016040)
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain (IPR006140)

1 50 100 150 200 250 300 364

Detailed signature matches

IPR006139

D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
1. PF00389 (2-Hacid_dh)
  
  44 - 354
  
  Pfam
  PF00389 (2-Hacid_dh)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  141 - 323
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR006140

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
1. PF02826 (2-Hacid_dh_C)
  
  149 - 323
  
  Pfam
  PF02826 (2-Hacid_dh_C)
IPR029752

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
1. PS00065 (D_2_HYDROX...)
  
  185 - 213
  
  PROSITE patterns
  PS00065 (D_2_HYDROXYACID_DH_1)
IPR029753

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
1. PS00671 (D_2_HYDROX...)
  
  263 - 279
  
  PROSITE patterns
  PS00671 (D_2_HYDROXYACID_DH_3)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

154 - 326

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

31 - 153

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
SSF52283 (Formate/g...)

31 - 173

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)
cd12168 (Mand_dh_like)

31 - 349

CDD
cd12168 (Mand_dh_like)

Residue annotation

putative ligand bi...

86L

putative ligand binding site
86L, 114G, 115A, 116G, 139V, 274R, 321H
CDD
cd12168 (Mand_dh_like)

114G

putative ligand binding site
86L, 114G, 115A, 116G, 139V, 274R, 321H
CDD
cd12168 (Mand_dh_like)

115A

putative ligand binding site
86L, 114G, 115A, 116G, 139V, 274R, 321H
CDD
cd12168 (Mand_dh_like)

116G

putative ligand binding site
86L, 114G, 115A, 116G, 139V, 274R, 321H
CDD
cd12168 (Mand_dh_like)

139V

putative ligand binding site
86L, 114G, 115A, 116G, 139V, 274R, 321H
CDD
cd12168 (Mand_dh_like)

274R

putative ligand binding site
86L, 114G, 115A, 116G, 139V, 274R, 321H
CDD
cd12168 (Mand_dh_like)

321H

putative ligand binding site
86L, 114G, 115A, 116G, 139V, 274R, 321H
CDD
cd12168 (Mand_dh_like)
dimerization inter...

141R

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

142G

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

145D

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

149F

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

152L

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

153G

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

156R

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

158F

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

159A

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

168N

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

170W

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

173D

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

174V

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

178H

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

179D

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

180P

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

181V

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

183K

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

199D

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

200R

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

203A

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

204F

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

300F

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

303E

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

304P

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

305K

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

311L

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

313N

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

316T

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

317L

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

318L

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

319L

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

320P

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

321H

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

322M

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

323G

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

326S

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

327V

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

328E

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)

330R

dimerization interface
141R, 142G, 145D, 149F, 152L, 153G, 156R, 158F, 159A, 168N, 170W, 173D, 174V, 178H, 179D, 180P, 181V, 183K, 199D, 200R, 203A, 204F, 300F, 303E, 304P, 305K, 311L, 313N, 316T, 317L, 318L, 319L, 320P, 321H, 322M, 323G, 326S, 327V, 328E, 330R
CDD
cd12168 (Mand_dh_like)
NAD binding site c...

143T

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

190M

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

191G

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

192G

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

193I

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

213N

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

214R

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

244S

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

245V

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

246P

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

247L

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

248N

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

251T

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

272T

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

273A

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

274R

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

298D

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

321H

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

323G

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)

324T

NAD binding site
143T, 190M, 191G, 192G, 193I, 213N, 214R, 244S, 245V, 246P, 247L, 248N, 251T, 272T, 273A, 274R, 298D, 321H, 323G, 324T
CDD
cd12168 (Mand_dh_like)
catalytic site cd1...

274R

catalytic site
274R, 303E, 321H
CDD
cd12168 (Mand_dh_like)

303E

catalytic site
274R, 303E, 321H
CDD
cd12168 (Mand_dh_like)

321H

catalytic site
274R, 303E, 321H
CDD
cd12168 (Mand_dh_like)

Protein sequence

>MCA_02492_1
MFPFFSRALRTSSVRSTFKYRAMSASASTTKPKVLLCGTIEHAHKEWEELGEIAQLEVLEGSLERDKFIEALKTKYNDVT
AIYRTLFSVTQTGRFDKELIAELPPTLKYICNFGAGYDQIDVDALTERNIQLSNTPNAVDRGTADTAFFLTLGILRNFAW
GAHQLRQNVWLKDVELGHDPVSKVLGIVGMGGIGRAYRDRAKAFGFKKIIYYNRRRLSPELEKDSEYCSSLDELFKQADV
ISLSVPLNSETKHLINKDTIAKMKDNVYIVNTARGPVIDEDALVEGLESGKIAGAGLDVFEHEPKIHPGLLNNHKTLLLP
HMGTHSVESRYDMEKLVLDNIRSALTTGKVITMVSEQVKDGRFA

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component