Protein
MIA_00179_1
Length
3,178 amino acids
Browser: contig01:502575-512463+
Protein function
| EGGNOG: | 0PHG3 | IRA2 | negative regulation of cAMP metabolic process |
|---|---|---|---|
| SGD closest match: | S000005441 | IRA2 | Inhibitory regulator protein IRA2 |
| CGD closest match: | CAL0000177461 | IRA2 | Ras GTPase activating protein |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_03049_1 | 50.126% | 2376 | 0.0 | MCA_03049_1 |
| A0A0J9X8R8_GEOCN | 39.386% | 2280 | 0.0 | Similar to Saccharomyces cerevisiae YOL081W IRA2 GTPase-activating protein that negatively regulates RAS by converting it from the GTP-to the GDP-bound inactive form OS=Geotrichum candidum GN=BN980_GECA05s04399g PE=4 SV=1 |
| UniRef50_A0A0J9X8R8 | 39.386% | 2280 | 0.0 | Similar to Saccharomyces cerevisiae YOL081W IRA2 GTPase-activating protein that negatively regulates RAS by converting it from the GTP-to the GDP-bound inactive form n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X8R8_GEOCN |
| A0A1E3PR02_9ASCO | 29.092% | 2169 | 0.0 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_63377 PE=4 SV=1 |
| Q6CFF4_YARLI | 26.296% | 2335 | 0.0 | YALI0B07535p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B07535g PE=4 SV=1 |
| A0A170QY52_9ASCO | 32.183% | 898 | 1.48e-153 | Ras GTPase activating protein IRA2 OS=Sugiyamaella lignohabitans GN=IRA2 PE=4 SV=1 |
| A0A1D8PFE8_CANAL | 21.112% | 1672 | 6.64e-75 | Ras GTPase activating protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IRA2 PE=4 SV=1 |
| IRA2_YEAST | 26.339% | 691 | 5.37e-54 | Inhibitory regulator protein IRA2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IRA2 PE=1 SV=2 |
| A0A060T599_BLAAD | 29.242% | 277 | 5.66e-17 | ARAD1B05698p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B05698g PE=4 SV=1 |
| A0A1E4TMB3_9ASCO | 29.240% | 171 | 1.90e-09 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_15563 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.8581
Predicted cleavage: 34
Protein family membership
None predicted.
Domains and repeats
-
Domain
-
Domain
1
500
1000
1500
2000
2500
3178
Detailed signature matches
no IPR
Unintegrated signatures
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CYTOPLASMIC_D... (C...)
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-
-
NON_CYTOPLASM... (N...)
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TRANSMEMBRANE (Tran...)
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mobidb-lite (disord...)
Protein sequence
>MIA_00179_1 MASGASAGHRSPKRKPSASAANTTLLPYFIHRLTSVLPVKTSYKIHEVEEEPTFVLSKDMLKELSTKGLTNEIIPGLLAL AKDTYKSDKGDIISKKSHLTLRSLVVLLNLLAEVLTAAWDSAQLQVDPNHHTAHISASLSQDFISYTVAPAPVPTGLVTN ALGFLMSIKPNTTLKTGLRSISNTVSVNREAEESQEYLLLSAIDSAIEKSIRYFSASNWTETYSLVHKVFEATLSGTPNQ TTDSDLIPGTELFAILFLDSSRVETVLTDFYKYSPRMKLPLHRLLIEHFLQQSLVSWAISRVPTIDNIDDHPNISKIASN LFDFIYGCSDDDRRRFSSWRFLSTLIIVVPEAFDAFEHYKPASPSLAPISSISLKPTSSLKRGNTDQPKKSAASKLKAFS NGLIGNNSSSSSISSHSSSHGNSSRGGGAYIARSSPASSSMSNSSLNPSVSSIPHSPRDKSIQKKINFLSSLSKLNNISA NSPLFLALLISCTEISKAAALAVTQTPDSPLIRFAKNLYNVLLTNLFPVTSCQALNPVTSLPHLYNYQCTFISSYTVLCR DAIIKDIYPILKSDDIGMLSYVPGILQGNVNLRLMPLFHETFTSMVDIIFPLFRETLIRAVKRLNFFESQVNLDSASTTS YKICVIIILKCYFIFTLNPENFLHNYVYLKHFDDDPIFYSVVHCGISNNEDIRRTTFAFAWSFLDKENLIAYDPVEVAKS LDHQVYTLFLHLGKLSQMLMEKVTRSNMGESDIIEHLGLIKGLMEGRCLLAHQYQFAKITKHNINAIEPADIRFDISNTL ETSMLILILSNNTKICKLALEVLNFMVQEAVITESPETESSSSWSIVSNFSVYSGLSSPSYIITGSMAVHKRLYQALQSA KANTPAILLAWRIIYEKWKTLTASLEQLTHIDSNMAKRWRAYSGFLASTVSAWIVEKDEPVIEGKLSKSSKIFLDQILTL LTNVHSSYLRETAREILSRDTNHSAYHFIFTTLEERLTLQLSKDHLDLHEEDFLLLEQSVSFLRAIIEYINDGEVYLAVD ITSLSLSIVKKLDRLIYSERVIKLRIQYASLIACISKHKDSMNMKHDLLIRNEVAFIFANWLDYSLSIHYTNEETDSIRS SDTTRLTHEKERLHKDCIVALIDSLASITLKLTIDTPENAQGRELYEIKSHKFSVLFMLLVRVLEKCRAEEMQLHTSLIL GDRLELVKNKTIECASKLLDANVDVGLKLALPLGIHEDPFIRVSFLKILDNILSHSSAQDLESEDATYEQLIDLLNENTK IVVTLGEVCPATEVDEFANALLEIFESRNNSLGLVKALVTREVERADTPMEILRRNCLATKLLSIYAHSKGISYLKKALS SFVQDLCDNPDEYTFETNPDKIPEDQTVDENIAKFEETLRKLIKALEDSLSFIPRDFRELCHTIAEAADSRYLGKNASIN AISAFFFLRFVCPSLVSPEGDGLIDRPPPREVRRTLLVLAKMVQNLAYGSGSFAKLSFFKDSSVDFSEDAAAVLRIVKSL TETVPMSPKQSHGGLSPNDLLLSPVDDNASSSLTTASVSTPQPIRAVDRASLEAFHWFLYSHWEDINHKLQTELRKARQV ASGHQHANNKSLLLSDPVNRANFMSARFEEDNDFRVRQKLTMLIRNLGRPKASETKKKAEAEVAINSLGVAPRLREFLER NSHRDMQPIIEKGIFHEGLSKEGMPLLIFSAQNYFRDGQDTELIVCRFFQVASKMWHQKFALFYDATGTTPENVLPLSAR SVINLMIPEIMAHNCVVAYLYNVPAEMIGYLRNTFRPYQTGKYLNPLTTRYTFLTSFDIADRFNLTTLNLDTRSLRVVND ARISYDGVQRINPEKRDSIKVSLKIGNEYVQFVGQEPFTLLKGAVGMFNSVYHFSEINSIELCTTNPDEFYVSISRGGKR RIILRSTRAHEIVRALIGAKARLPKSSVAFPADSNAQLYQTLDSSIGSLLNVSFSGLCSADPAARSSAYNLLATVQARFK LNLGVSDMLRGRGLRLPANVFSQVQQYSRVVAEHYPELTHDMVSELFAAYNSTEMSRRIGILAYITPWIKHLGTHVYSLE PTKYKRGTTAGFIRRFLELSFSDAADYVYLISSIWPVILEDSITMPILIEEFLVLVMEKNLVYSTSIDDYISILTSSKSL DAVYVVKEKLFDVLQQATSVTDSNIVNCPQWNEIVLLVNILSSMLFENPEAAMTHPSEYCFIVHMLLYTGSYSFRSLLYA MMVNYVHSLITSEVITPEARSHALTIYKDLTGDKGNMIFGTSEELRNVEFSYPVTSLLFQMDSLNAMTIELARTVMPIRG LEHQHEVFMQRCLVMSTQPTSTLQSRAIVALGSSSRLDVNDSMVTVVLGVLSDALNRDNSKMREELITCVAFSISKMVNG LQADSKYYGYLFWVSIALMNTYNMEIFGHGLQLFLACLKSLDDYGVFKQMSMSQYLLSSKEEFRGEWEKLETTLDLHFSE KHFELGLAATLLRGMVKSVTRAATLSAFDTLLSISAKNQMFRERENSVVATSKIPNLALTTDVSSILSDYGSGNRSSGNK SSLGQFGHRSSIAPTDLLEVDDTSTSSMPYSRGFPSYLVYLFFLYLGSRSQSDLRDYLWIAGYPEDYLEDEIPRPIRRFI GSGRTKSIVTLYLGALLYTQVEDEEKLGKRFLDVMKFVGSVNLTSYFRAYFVIRPKVKRTIDLAPGVELMRGALECAKVS LLNYEELRRPQFYLNGLDEVLLQAGLGPSKCSGGFISNTTPGFVSGNIVGATSKTSHSNSNNNSGNSSSTFTAESNSGLT GSSSSSSGNGHINLKDTGGAVQRNSSIMIKSKSSGTASSSNNLAELSHSILMNSGKSSHVSPHPITHPELTSSILTDEDL AAFIRKVAEVAHEHYCKRPGGFGSGATSHLANTCKDDDISLFQEEDEEEDDEEEEDFLKEKEEGGQYELGVGQKADSNNK EKEGLFDVGPTSTTAKSLPESTATMTTIINKSGAAARDLSPTTTASGTGELNSNGHEGNTSSVSSTSTGSNSPAGAETSS TLVTGNKLINTVTGTNEKGTAESTSATNDNHNAGGTRGSSQKAGDAHNHIGHDIDEGHEGQKGSREALPASAGPTIPPAA QLPPRSPILSPSSPSPKNTGAIVHIPGTPVTMVVGGSGSGKGVDSQDLGEPEERYYSS
GO term prediction
Biological Process
GO:0007165 signal transduction
GO:0043087 regulation of GTPase activity
Molecular Function
GO:0005488 binding
Cellular Component
None predicted.