Protein
MCA_03049_1
Length
2,923 amino acids
Gene name: IRA2
Description: Inhibitory regulator protein Ira2; GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form
Browser: contigB:3190958-3199899+
RNA-seq: read pairs 2790, FPKM 11.8, percentile rank 28.9% (100% = highest expression)
Protein function
| Annotation: | IRA2 | Inhibitory regulator protein Ira2; GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form | |
|---|---|---|---|
| KEGG: | K08052 | NF1 | neurofibromin 1 |
| EGGNOG: | 0PHG3 | IRA2 | negative regulation of cAMP metabolic process |
| SGD closest match: | S000005441 | IRA2 | Inhibitory regulator protein IRA2 |
| CGD closest match: | CAL0000177461 | IRA2 | Ras GTPase activating protein |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_00179_1 | 49.47% | 2379 | 0.0 | MIA_00179_1 |
| A0A0J9X8R8_GEOCN | 42.08% | 1105 | 0.0 | Similar to Saccharomyces cerevisiae YOL081W IRA2 GTPase-activating protein that negatively regulates RAS by converting it from the GTP-to the GDP-bound inactive form OS=Geotrichum candidum GN=BN980_GECA05s04399g PE=4 SV=1 |
| UniRef50_A0A0J9X8R8 | 42.08% | 1105 | 0.0 | Similar to Saccharomyces cerevisiae YOL081W IRA2 GTPase-activating protein that negatively regulates RAS by converting it from the GTP-to the GDP-bound inactive form n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X8R8_GEOCN |
| A0A170QY52_9ASCO | 34.46% | 888 | 4e-157 | Ras GTPase activating protein IRA2 OS=Sugiyamaella lignohabitans GN=IRA2 PE=4 SV=1 |
| A0A1E3PR02_9ASCO | 29.47% | 1130 | 4e-132 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_63377 PE=4 SV=1 |
| Q6CFF4_YARLI | 25.49% | 1122 | 6e-98 | YALI0B07535p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B07535g PE=4 SV=1 |
| IRA2_YEAST | 24.16% | 712 | 7e-49 | Inhibitory regulator protein IRA2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IRA2 PE=1 SV=2 |
| A0A1D8PFE8_CANAL | 21.15% | 780 | 4e-40 | Ras GTPase activating protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IRA2 PE=4 SV=1 |
| A0A060T599_BLAAD | 28.63% | 241 | 8e-18 | ARAD1B05698p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B05698g PE=4 SV=1 |
| A0A1E4TMB3_9ASCO | 26.22% | 225 | 6e-11 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_15563 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.4113
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
500
1000
1500
2000
2500
2923
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
mobidb-lite (disord...)
Protein sequence
>MCA_03049_1 MALPKGSRPTPAPVNASITTPHKYSPPPMTPTVDSSPPQTILPYFIGRLLNILPIRTGYTIEQVEEDPAFILTKDTLTDL SANGLATEIFPGILALIKDISKNDKAELISQKHYLTLRSITVLLRLMADVLKASWNATQLKADPQFRFSNIDEDFICYTV APPPCSPQMATKTINFLLSIKPNSSLKSALRKISVASSSQSNSNVSIISREETKETFLFKQIDISIESILYYLSASNWDE IYSVIIDKLEASTKLNPDETNDSEIIPALEIFGNLYLDASRTEKILFDFYTYAPKIKVPLNRLMLEYFLQQSIHYSVLSH PAEFSDPSPDTPLSSIASKLFDFIYSCSDDDKRRPSSWKFLSTLIALSPISFDAFLQHAPQQSSSKLKVFSSSKLRSIVS NNSSNTSKSSLDDPSSLPSSSSSSIINKKDKQIQKKISFLNTLSKLSNSSSKNPMFISFLVSYTEIVQAAAILSINAPDT SLVHFARSVFNNLLNHLFLHNSHSKSSKARNWDEFQHLFVTSYSVLCPDKIISEIFPMLKSDDDKIIAFIPSILQGCIQL RLIPCLIPTFQYITDHTYSLFRDALIRSVRKLKHMEAQPGFTEETMSTPSYTLYASVILKVYFIYTLRPELLNYGYTYQR SFEHDPVFYSVANSLLSQNLGIREQAFKFAWSFVDKSNLASYDPDEVARDTSHPVYTVFLHFGKVAQFMAEKVLAQQMED EDVIEHLRIVKNLAESRCFLAHQYQFSRVTGGDIHLIEPAEVRREISEILETTMLIFLLSNNTHICKLALEVLNWMVQEA IIVENLDIPEESTWSIVNNFSMYSELSSTSYVITGAIAVHKRLYHFLRNCNRNTKAVVNAWKYIIVQWRDLTYSIRSKTS LDRELAKRWRAYGGFLASSVSSWLVTEGEQVYEGKLTSSSKKFLTILLDLITDEDSFIRETSREILSRDTNHSAFHFVFI SLEERLTDQISKENSTLTEKDYSLLEQSVLFLRAIIDYINDGEVYLAVDIASLALSIVKKLDTLDITTRVIKLHMQYANL MALITKHKDVMNLKHDLHVRNEVAVIFASWLDRKISFQYSSEDMESVASSNTYHVEKRKILERERLQKDCIASLIESFAA ITLKMKIEVPADTHEKDVYETKSHKFSVYIMLLLRILEKCRAEELHTRRSIGLGDRLEFVKKKTIEAASKLLDANVDVGL RAAFPLAYHEDPFIRISFIKILDNILSHSSDTDETSELSEKATYQELAEFLGTNLNISLSLCDVCPATEVDEFSAAILKV FENQQNALGLVKAVVTKEVERADTPVEILRRNCVATKILSIYAHELGYEYLKTALSPFIKEVQSHPELYVFETNPDKIPE GETIEQNLTKFDRTLKKLLTALDTSMYCIPAVFREICLTISETAENKYAATSNSRHASVNAISAFFFLRFICPSLVSPET DGLVDEPPSKDVRRTMLILAKMIQNLAYGSNQFVKLSIFKNAAFSFRQYSVSVVRILKSLTTMPDAPVLDDTASSNTSVG SSMHTNKSVDLDKMAVIHKFMYSHWEDINHKIQTEMKIKRHHNSNSHKNSSSNGTVSNTNASIASNSLSLNNVESSKRSV ISSTGSTSSDDDDFKATQRLTSFIRNLGRPRQIDTKSIDHMSGIKGLTDGVSDENSSSTQIPPRLKEFLARNSHRNMDSV IEQRIITEGLTKEGMPLLVLNTQNYVRDSQDTELIVCRYFHVASKIWNQKFGIFYDSTNSSADNFLSTSAKAFINLLVPD IMANNCICVYFYNIPLEYVPHMKTALKQQQNGTYLNPLRTKFYFITTQDIIGKFNLNALNLDPKSLRVLHDAKLNFTGVQ LISSEKKTTMLVSLRLGSEYLQIQSQDPYHIMKGVSGFGNSVYSLRDIHRVELTPGHSEEMTIYLIQRGEKKKLYLKTNK ASDIVRSILNSKSRMQTNNNTSASQASVTSPEVQLYQTLESGIGSFLNIAFSSLCSNDHQMKNAAYNLLATTRKKFNLDL DGVDLIRGKGLKLPANVFSYIRKYSRSVAETRPELSHSMIDEMFEAYKSLAQDRRQGVLMYISPWIKNMAKHIYSHEGET YQKGTCRQIIRKLLELCLENDQDYMFFLQDIWPLIIKESDLLPILVDELLSLVLKSGLVPENKKEDVMAILTAHQSLEAC ELLINRILDIALQPACIKDNKLVNHPQWPEVVLLISALSSMLFENPQAVVKYCADLCLIVQMHLYTGPYSFRLSLYNMLA NMTHSLLYSDSIKPDNKAHIMTIWKDLTSNKGSMIFGISDEMKNVENDFAVTSIMFQIESCSSILLDLARSISASKKLDV YHERFSKQFLLLCTQRYSILQSRAIVTLGCISRFDISDDNVTVILEVLLDSLTSDDYKMKEELITCAAFSISKMATGLRV DSKYHGYLFWVAIATMNTQNMRIFSYGLQLLQTVLKSLDEYGVFKEISVSSYLLKSKEALKAEWEEIEELMDLTFTRDYF EIAVVSSLIPGMVRSSTRAETLQALETLLTIAARNYQTRGRESSIVGVTSGSNSMSSPGTPGNSHSNGPNSDNISLLSDS SRSMNPYQTLHHSSSNSNLHAKESGSHSATSSLFSYSTVGHRFSAGGFNESAFGDEVSANSISYVKDHPEFMIFLFFLYL GTRSKSNLRDYLWIAGYLEDLGEDEIPTPLQRFISSGNTAKSTVALYLGALLYNQVEDEETLTLKFLKVLKFVGESISVH RFFPIYFVVRPKIKKTIDLAPNVVVIKAALSCAKIALLNLEDLSRPTFFLQELNAILKKAGLGQSKCSGGFGIKNNNNNN NSGSVNSFNAFYQHNNSQTSSNQPPPTPKSPQDQMALLSLSDEAADNNKPKEQQPFDLEAESDRRLSHFLKRLVELYRSN AIKGNVNTSLLANDDAMLTSHGTNNNNDKNILQEEEEEEDDEL
GO term prediction
Biological Process
GO:0007165 signal transduction
GO:0043087 regulation of GTPase activity
Molecular Function
GO:0005488 binding
Cellular Component
None predicted.