Protein

MIA_00133_1

Length
460 amino acids

Browser: contig01:367305-368688-

Protein function

EGGNOG:0PGE1SUB7Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity (By similarity)
SGD closest match:S000005529YSP3Subtilisin-like protease 3
CGD closest match:CAL0000199552PRB1Prb1p

Protein alignments

%idAln lengthE-value
MCA_03837_158.12%4990.0MCA_03837_1
A0A0J9XHJ8_GEOCN53.60%4036e-144Similar to Saccharomyces cerevisiae YOR003W YSP3 Putative to the subtilisin-like protease III OS=Geotrichum candidum GN=BN980_GECA17s00296g PE=3 SV=1
UniRef50_A0A0J9XHJ853.60%4031e-140Similar to Saccharomyces cerevisiae YOR003W YSP3 Putative to the subtilisin-like protease III n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XHJ8_GEOCN
A0A060T1Y8_BLAAD44.19%3871e-102ARAD1A03322p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A03322g PE=3 SV=1
A0A167DJQ7_9ASCO42.60%3926e-102Proteinase B OS=Sugiyamaella lignohabitans GN=PRB1 PE=3 SV=1
A0A1E3PH86_9ASCO43.08%3901e-96Subtilisin-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47354 PE=3 SV=1
Q6C486_YARLI36.36%3962e-61YALI0E28875p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E28875g PE=3 SV=1
Q59Z57_CANAL32.03%4622e-59Prb1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PRB1 PE=3 SV=1
YSP3_YEAST35.59%3405e-58Subtilisin-like protease 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YSP3 PE=2 SV=2
A0A1E4THC1_9ASCO35.93%3986e-43Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_65053 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7643
Predicted cleavage: 25

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 460

Detailed signature matches

  1. Family IPR015500
    Peptidase S8, subtilisin-related
    1. PR00723 (SUBTILISIN)
  2. Domain IPR010259
    Peptidase S8 propeptide/proteinase inhibitor I9
    1. PF05922 (Inhibitor_I9)
    2. G3DSA:3.30.70.80
  3. Domain IPR000209
    Peptidase S8/S53 domain
    1. G3DSA:3.40.50...
    2. PF00082 (Peptidase_S8)
    3. SSF52743 (Subtilisi...)
  4. Domain IPR034193
    Proteinase K-like catalytic domain
    1. cd04077 (Peptidases...)
  5. SITE IPR022398
    Peptidase S8, subtilisin, His-active site
    1. PS00137 (SUBTILASE_HIS)
  6. SITE IPR023828
    Peptidase S8, subtilisin, Ser-active site
    1. PS00138 (SUBTILASE_SER)
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SignalP-noTM

Residue annotation

  1. calcium binding si...
  2. active site cd04077
  3. catalytic triad cd...
  4. calcium binding si...

Protein sequence

>MIA_00133_1
MKLSVTLSSMAMAWRCLVHLAAASPLVAEFEASFPTDAAIAPEKDALELLPRDQTADIAESPNGKQAGNSNLLQDYIVIL
KDETGQTLARRSAHRAWLDELLSKRQSLNARDAQPAPPPIDFDSTADVEASKAIMGYHGAFTEAEIKAIASSEDVAFVER
ESYDTIQQDFVYVQYNTPWGLGRISHKSFDSPAGTDDATYVFGSQGGANTTLYVLDSGVRADHVEFTGRVRWGANYIDNE
QTDVHGHGTHISGIAAGHNVGVAKFANIVAVKVIDADRRAAISNIIKGVQWIIDDAAANPGSRAVINYSAVGVISDARTL
AIQKAVDAGIMVVTAAGNSAADACSYGPANMAASTDGVLTVAALNYTNTPADFSNYGGCVSVYAPGVSILSASKDAVNSY
KYMSGTSMSSPYVAGLAAYFWSINSGYSLSDVKSAILNYNDGQIVDAVGNTANKIAYNHQ

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

None predicted.