Protein

MCA_03837_1

Length
489 amino acids

Gene name: YSP3

Description: subtilisin-like peptidase

Browser: contigC:1238710-1240180-

RNA-seq: read pairs 2490, FPKM 62.8, percentile rank 70.2% (100% = highest expression)

Protein function

Annotation:YSP3subtilisin-like peptidase
KEGG:K01336E3.4.21.48 cerevisin [EC:3.4.21.48]
EGGNOG:0PGE1SUB7Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity (By similarity)
SGD closest match:S000005529YSP3Subtilisin-like protease 3
CGD closest match:CAL0000175297orf19.7196Proteinase B

Protein alignments

%idAln lengthE-value
MIA_00133_158.32%4990.0MIA_00133_1
A0A0J9XHJ8_GEOCN50.92%4349e-146Similar to Saccharomyces cerevisiae YOR003W YSP3 Putative to the subtilisin-like protease III OS=Geotrichum candidum GN=BN980_GECA17s00296g PE=3 SV=1
UniRef50_A0A0J9XHJ850.92%4342e-142Similar to Saccharomyces cerevisiae YOR003W YSP3 Putative to the subtilisin-like protease III n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XHJ8_GEOCN
A0A167DJQ7_9ASCO42.51%3742e-99Proteinase B OS=Sugiyamaella lignohabitans GN=PRB1 PE=3 SV=1
A0A060T1Y8_BLAAD43.16%3732e-98ARAD1A03322p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A03322g PE=3 SV=1
A0A1E3PH86_9ASCO41.51%4241e-97Subtilisin-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47354 PE=3 SV=1
Q6C486_YARLI33.07%5112e-72YALI0E28875p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E28875g PE=3 SV=1
A0A1D8PRH0_CANAL36.23%3454e-59Proteinase B OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.7196 PE=3 SV=1
YSP3_YEAST34.82%3592e-58Subtilisin-like protease 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YSP3 PE=2 SV=2
A0A1E4TAU4_9ASCO38.31%2955e-46Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_16776 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1696

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 489

Detailed signature matches

  1. Family IPR015500
    Peptidase S8, subtilisin-related
    1. PR00723 (SUBTILISIN)
  2. Domain IPR000209
    Peptidase S8/S53 domain
    1. G3DSA:3.40.50...
    2. PF00082 (Peptidase_S8)
    3. SSF52743 (Subtilisi...)
  3. Domain IPR010259
    Peptidase S8 propeptide/proteinase inhibitor I9
    1. PF05922 (Inhibitor_I9)
    2. G3DSA:3.30.70.80
  4. Domain IPR034193
    Proteinase K-like catalytic domain
    1. cd04077 (Peptidases...)
  5. SITE IPR022398
    Peptidase S8, subtilisin, His-active site
    1. PS00137 (SUBTILASE_HIS)
  6. SITE IPR023828
    Peptidase S8, subtilisin, Ser-active site
    1. PS00138 (SUBTILASE_SER)
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SignalP-noTM

Residue annotation

  1. calcium binding si...
  2. active site cd04077
  3. catalytic triad cd...
  4. calcium binding si...

Protein sequence

>MCA_03837_1
MKFSLPVSTILSAFFVAQYISASVVPATFEAKLPDPKDIMPETDSQMLLPRDNSLPENLENKKYNDYIVIFDEKASHQKR
SLHQQWLVNDVLKKREFTDEDSGITEEYDVAAIVDDDIAKRDEEYDYIQLFEEGKRKKMKKRNIPAGIKGFFNQDQASDK
HAINGYYGTFSEEEVEQIKSSGDVKIVERESYDQIQSNFVYIQYNTTWGLGRISHKTFDSPLGTDDSTYVFGSQGGKGTT
LYILDSGVREDHIEFTGRVRWGANYIDDKNNDAHGHGTHITGIAAGHNVGVAKFANIVAVKVIDSQRRAAISNIIKGVQW
IIEDHKKNPNQRSVINYSAVGSISEARTHALQQAVDAGIMVVTAAGNSAADACQYGPANMAATSDGVISVAALNYTNTPA
YFTNYGPCATVYAPGVSILSAANDTTSAYQYMSGTSMSSPFVAGLAAYFWSLNPQYTLSQVKDLIINYNQDQIKGNLPNT
ANKIAYNHL

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

None predicted.