Protein

MIA_00121_1

Length
1,338 amino acids

Browser: contig01:334200-338260+

Protein function

EGGNOG:0QDFSRAD5helicase, member of the UBC2 RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild- type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity)
SGD closest match:S000004022RAD5DNA repair protein RAD5
CGD closest match:CAL0000193075RAD5DNA repair protein RAD5

Protein alignments

%idAln lengthE-value
MCA_02615_141.775%14650.0MCA_02615_1
A0A0J9X9F4_GEOCN40.086%13920.0Similar to Saccharomyces cerevisiae YLR032W RAD5 DNA helicase proposed to promote replication fork regression during postreplication repair by template switching OS=Geotrichum candidum GN=BN980_GECA06s01077g PE=4 SV=1
UniRef50_A0A0J9X9F440.086%13920.0Similar to Saccharomyces cerevisiae YLR032W RAD5 DNA helicase proposed to promote replication fork regression during postreplication repair by template switching n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9F4_GEOCN
A0A060T5S8_BLAAD39.924%13100.0ARAD1B09856p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B09856g PE=4 SV=1
A0A167FAC0_9ASCO40.121%13260.0DNA helicase RAD5 OS=Sugiyamaella lignohabitans GN=RAD5 PE=4 SV=1
A0A1E3PCQ5_9ASCO39.558%12210.0Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_39087 PE=4 SV=1
RAD5_YARLI33.413%12570.0DNA repair protein RAD5 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=RAD5 PE=3 SV=1
RAD5_YEAST32.386%11616.21e-172DNA repair protein RAD5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD5 PE=1 SV=1
RAD5_CANAL33.113%10572.67e-170DNA repair protein RAD5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RAD5 PE=3 SV=2
A0A1E4TLD5_9ASCO32.913%7141.91e-113Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_15482 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0130

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 200 400 600 800 1000 1200 1338

Detailed signature matches

  1. Domain IPR014905
    HIRAN domain
    1. PF08797 (HIRAN)
    2. SM00910 (HIRAN_2)
  2. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  3. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  4. Domain IPR000330
    SNF2-related, N-terminal domain
    1. PF00176 (SNF2_N)
  5. Domain IPR013083
    Zinc finger, RING/FYVE/PHD-type
    1. G3DSA:3.30.40.10
  6. Domain IPR001841
    Zinc finger, RING-type
    1. SM00184 (ring_2)
    2. PS50089 (ZF_RING_2)
  7. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. G3DSA:3.40.50...
  3. SSF57850 (RING/U-box)
  4. cd00046 (DEXDc)
  5. cd00079 (HELICc)
  6. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. putative Mg++ bind...
  3. nucleotide binding...
  4. ATP-binding site c...

Protein sequence

>MIA_00121_1
MVTDRNDTFQHLLEGESLESFSSFSSLDIPTAKRIKFFHRYPNSGDKNNESSNLESLKSASRSDTIENMPPPSDRSNTQA
QMKAATEDPTFRTELEAIVGPLSTPKFLELRDRSSGNVNRAVNILFDEQSQSPSKVRTNEKSPLHSSLPTRSLSAHRITA
SQNTDPKLDRASQNTLENSLPLEISQEPLANSTPIIENQTKSLNQTKSRSKTPDVPAVATRNHSSQYLSPDYDYTWTERY
IGSLQADIMVTRSGKNLIHYQESLSVISSTSSFSANNNKSDSFVRIANSKGLEIGRFIGDIARVVSILMDTGTCTFKATC
IFADSKLRIGDQFFIQLDCYLLRHAFNGTDIVKIHEITGINDPTDPQQHINQALAQADSTSRLIGGNGIAASQLSPRKRM
SQSIPTTKAFFNNSRESLDETILKTRQKALVSIFNKVSMKPLQRSKKENTSTNPINLSNEELFAQLEKASEMAAVTSTEK
QDEPENADTDKQTNMEGAEEPNFDQAQLDTVYRRTSEAQDRMLEEVDPGDTFAMKLRPYQKRGLNWMLRRESPEQYHGNS
VERDADGTIIEPMNPLWQEFRWPDDPNFSLKDGSKPLGPPTFYVNLYAGDMSLKFPRQKKMVQGGILADEMGLGKTISTM
AVIHTNKYSEQTEYDENLPSSQVLREKRDKRGDFAKYTTLIVAPMSLLSQWESEALASSKKGTTRVLVYYGSAATSVNLR
SLLCGPNAKREAPNVIITSYGTLASEHTTLLRYRKRQLNLKATGRTIDGNPIKRRRVDTEDDQNHIWDDLGADDWEDDAD
LGLFGLYGVEFYRVVLDEGHIIKNRTTKTAKACYDIRSQRRWVLTGTPIVNRLEDLFSLIKFLGAEPWNNFAFWKTFITV
PFMNKDLERALTVVQSVMEPILLRRTKQMKGPDGKPLVELPSKEVHVVSVKLGPEERSIYDLIFASAKSAFDSNVNNGTV
MKSYTTILAQILRLRQACCHPSMVTEALLAQQKFPNNSMTINKIEELVADYNNTKPVKDQNTITSSQTEEKFEYEVLNAL
QQGNPVECPICLTENILQEDMAVTECFHISCMDCVLKHIELSKKLHGNPQCPICCAPISEDNLFTVQREPLQISDVSKKE
KAEDVKPKIRLQQYNSRGQSAKVQFLLRKLRETQRHNQKELCEKGPVSLVKGRTKNSNNPNIIKTVIFSQFTEYLDIIER
ALTADGFSSLRFDGSLSQAERARVLSRFKGESNDTNIQYDVLLISLKAGGVGLNLVCAQQVFLMDPWWSYAVEAQAIDRI
HRMGQEHTVNVYRVIAENSVEEKILRIQERKIALASSIGMTEEERKAQRMDDIKLLFQ

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Cellular Component

None predicted.