Protein

MIA_00112_1

Length
445 amino acids

Browser: contig01:300613-301951-

Protein function

EGGNOG:0PG7CPGUG_02249gamma-glutamyl phosphate reductase
SGD closest match:S000005850PRO2Gamma-glutamyl phosphate reductase
CGD closest match:CAL0000189309PRO2Glutamate-5-semialdehyde dehydrogenase

Protein alignments

%idAln lengthE-value
MCA_05264_175.450%4440.0MCA_05264_1
A0A167E692_9ASCO65.996%4470.0Glutamate-5-semialdehyde dehydrogenase OS=Sugiyamaella lignohabitans GN=PRO2 PE=3 SV=1
A0A1E3PE09_9ASCO67.426%4390.0Gamma-glutamyl phosphate reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47970 PE=3 SV=1
A0A0J9X8B5_GEOCN67.347%4410.0Similar to Saccharomyces cerevisiae YOR323C PRO2 Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis OS=Geotrichum candidum GN=BN980_GECA05s02353g PE=3 SV=1
Q6C421_YARLI67.202%4360.0YALI0E30481p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E30481g PE=3 SV=1
A0A060TCJ4_BLAAD65.000%4400.0ARAD1D36586p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D36586g PE=3 SV=1
A0A1E4TJ54_9ASCO63.510%4330.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30095 PE=3 SV=1
Q5ADR2_CANAL61.048%4390.0Glutamate-5-semialdehyde dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PRO2 PE=3 SV=1
UniRef50_Q9UT4456.982%4444.00e-176Probable gamma-glutamyl phosphate reductase n=220 Tax=cellular organisms TaxID=131567 RepID=PROA_SCHPO
PROA_YEAST56.984%4512.32e-178Gamma-glutamyl phosphate reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRO2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5944
Predicted cleavage: 15

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 445

Detailed signature matches

  1. Family IPR012134
    Glutamate-5-semialdehyde dehydrogenase
    1. PIRSF000151 (GPR)
  2. Domain IPR016162
    Aldehyde dehydrogenase N-terminal domain
    1. G3DSA:3.40.60...
  3. Domain IPR016161
    Aldehyde/histidinol dehydrogenase
    1. SSF53720 (ALDH-like)
  4. Domain IPR015590
    Aldehyde dehydrogenase domain
    1. PF00171 (Aldedh)
  5. Domain IPR000965
    GPR domain
    1. cd07079 (ALDH_F18-1...)
    2. MF_00412 (ProA)
    3. TIGR00407
  6. SITE IPR020593
    Gamma-glutamyl phosphate reductase GPR, conserved site
    1. PS01223 (PROA)

Residue annotation

  1. putative catalytic...

Protein sequence

>MIA_00112_1
MSSQAETIAKTARRASNIIKTLSNEQRSAALKSIYDTLRDHKTQILEANEKDLVEARKANLPGSLIKRLDLTVGDKYDSM
LQGVLDVAALDDPVGKITLATKLDEGLDLYRVTVPVGVLLVIFEARPEVIANISALALKSGNAAILKGGKESTHTFKAMA
ACVTKALEATGTVPAHTIQLITTREEVGSLLSQDLYIDLVIPRGSNALVRHIKEHTKIPVLGHADGICSIYVAKDADPEM
AARIVVDSKTNYPAGCNAVESLLLDETVLSTKTFPIIIEALLKAGVTLKVTPEIELWITKNNISIPESVKVLPATEQDFY
TEFLDHVIAIKSVQSLADAIEHINEHGSHHTDCIITKDESEASTFLKGVDSAGVYWNASTRFADGFRYGFGTEVGISTNK
IHARGPVGLEGLVGYHYQLKGHGQIAADYAGAGGSKQFLHTPINH

GO term prediction

Biological Process

GO:0006561 proline biosynthetic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004350 glutamate-5-semialdehyde dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding

Cellular Component

None predicted.