MIA_00111_1

Protein

Length

1,378 amino acids

Protein function

EGGNOG:	0QE8C		phospholipid-transporting ATPase
SGD closest match:	S000000024	DRS2	Probable phospholipid-transporting ATPase DRS2
CGD closest match:	CAL0000194034	orf19.6778	Phospholipid-transporting ATPase

Protein alignments

	%id	Aln length
MCA_00858_1	81.51%	1352	MCA_00858_1
A0A0J9XKK8_GEOCN	80.58%	1282	Phospholipid-transporting ATPase OS=Geotrichum candidum GN=BN980_GECA32s00131g PE=3 SV=1
A0A060TC31_BLAAD	71.54%	1286	Phospholipid-transporting ATPase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D36564g PE=3 SV=1
A0A1E3PF95_9ASCO	74.67%	1196	Phospholipid-transporting ATPase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_28338 PE=3 SV=1
Q6C3I4_YARLI	67.19%	1277	Phospholipid-transporting ATPase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E34551g PE=3 SV=1
UniRef50_A0A022VXU5	60.28%	1362	Phospholipid-transporting ATPase n=3 Tax=Trichophyton rubrum TaxID=5551 RepID=A0A022VXU5_TRIRU
Q5ADR3_CANAL	68.51%	1178	Phospholipid-transporting ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6778 PE=3 SV=1
ATC3_YEAST	62.08%	1279	Probable phospholipid-transporting ATPase DRS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DRS2 PE=1 SV=2
A0A1E4TK42_9ASCO	61.72%	1199	Phospholipid-transporting ATPase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_22881 PE=3 SV=1
A0A167E6A2_9ASCO	76.68%	776	Phospholipid-transporting ATPase OS=Sugiyamaella lignohabitans GN=DRS2 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0029

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily IV (IPR006539)

Domains and repeats

Domain
254 - 320
P-type ATPase, N-terminal (IPR032631)
350 - 421
P-type ATPase, A domain (IPR008250)
460 - 501
P-type ATPase, A domain (IPR008250)
1,043 - 1,295
P-type ATPase, C-terminal (IPR032630)
Domain
267 - 354
P-type ATPase, transmembrane domain (IPR023298)
502 - 623
P-type ATPase, transmembrane domain (IPR023298)
1,064 - 1,294
P-type ATPase, transmembrane domain (IPR023298)
Domain
592 - 641
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)
636 - 871
P-type ATPase, cytoplasmic domain N (IPR023299)
869 - 1,059
HAD-like domain (IPR023214)

1 200 400 600 800 1000 1200 1378

Detailed signature matches

IPR001757

P-type ATPase
1. TIGR01494
  
  986 - 1,096
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
  
  554 - 656
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
IPR006539

P-type ATPase, subfamily IV
1. TIGR01652
  
  267 - 1,302
  
  TIGRFAMs
  TIGR01652 (TIGR01652)
IPR032631

P-type ATPase, N-terminal
1. PF16209 (PhoLip_ATP...)
  
  254 - 320
  
  Pfam
  PF16209 (PhoLip_ATPase_N)
IPR023298

P-type ATPase, transmembrane domain
1. SSF81665 (Calcium A...)
  
  267 - 354
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  1,064 - 1,294
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  502 - 623
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR008250

P-type ATPase, A domain
1. SSF81653 (Calcium A...)
  
  350 - 421
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
  
  460 - 501
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR023214

HAD-like domain
1. SSF56784 (HAD-like)
  
  617 - 641
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  869 - 934
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  979 - 1,059
  
  SUPERFAMILY
  SSF56784 (HAD-like)
2. G3DSA:3.40.50...
  
  872 - 1,057
  
  GENE3D
  G3DSA:3.40.50.1000 (G3DSA:3.40.50.1000)
IPR023299

P-type ATPase, cytoplasmic domain N
1. SSF81660 (Metal cat...)
  
  636 - 834
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
2. G3DSA:3.40.11...
  
  592 - 636
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
  
  637 - 871
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR032630

P-type ATPase, C-terminal
1. PF16212 (PhoLip_ATP...)
  
  1,043 - 1,295
  
  Pfam
  PF16212 (PhoLip_ATPase_C)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  631 - 637
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

589 - 1,073

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

333 - 516

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,220 - 1,230

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,281 - 1,378

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,137 - 1,156

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
Coil

846 - 866

COILS
Coil (Coil)

1,376 - 1,378

COILS
Coil (Coil)
G3DSA:2.70.15...

304 - 504

GENE3D
G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
NON_CYTOPLASM... (N...)

1,249 - 1,259

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

540 - 566

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,180 - 1,198

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,095 - 1,113

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1 - 313

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF00122 (E1-E2_ATPase)

348 - 538

Pfam
PF00122 (E1-E2_ATPase)
PF13246 (Cation_ATPase)

705 - 797

Pfam
PF13246 (Cation_ATPase)
PR00119 (CATATPASE)

1,015 - 1,034

PRINTS
PR00119 (CATATPASE)

629 - 643

PRINTS
PR00119 (CATATPASE)

893 - 903

PRINTS
PR00119 (CATATPASE)
TMhelix

1,108 - 1,127

TMHMM
TMhelix (TMhelix)

566 - 588

TMHMM
TMhelix (TMhelix)

1,157 - 1,179

TMHMM
TMhelix (TMhelix)

1,194 - 1,216

TMHMM
TMhelix (TMhelix)

1,258 - 1,280

TMHMM
TMhelix (TMhelix)

1,074 - 1,093

TMHMM
TMhelix (TMhelix)

1,223 - 1,245

TMHMM
TMhelix (TMhelix)

517 - 539

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

1,114 - 1,136

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,157 - 1,179

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

314 - 332

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,231 - 1,248

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,074 - 1,094

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,199 - 1,219

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

517 - 539

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

567 - 588

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,260 - 1,280

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd02073 (P-type_ATP...)

269 - 1,175

CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)
mobidb-lite (disord...)

1 - 77

MobiDB Lite
mobidb-lite (disorder_prediction)

203 - 224

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

phosphorylation si...

631D

phosphorylation site
631D
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)
P-type ATPase sign...

631D

P-type ATPase signature motif
631D, 632K, 633T, 634G, 635T, 636L, 637T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

632K

P-type ATPase signature motif
631D, 632K, 633T, 634G, 635T, 636L, 637T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

633T

P-type ATPase signature motif
631D, 632K, 633T, 634G, 635T, 636L, 637T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

634G

P-type ATPase signature motif
631D, 632K, 633T, 634G, 635T, 636L, 637T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

635T

P-type ATPase signature motif
631D, 632K, 633T, 634G, 635T, 636L, 637T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

636L

P-type ATPase signature motif
631D, 632K, 633T, 634G, 635T, 636L, 637T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

637T

P-type ATPase signature motif
631D, 632K, 633T, 634G, 635T, 636L, 637T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)
putative ATP bindi...

631D

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

632K

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

633T

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

765F

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

788K

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

789G

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

790A

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

854E

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

901T

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

902G

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

903D

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

991R

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

994P

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

997K

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

1,017D

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

1,020N

putative ATP binding site
631D, 632K, 633T, 765F, 788K, 789G, 790A, 854E, 901T, 902G, 903D, 991R, 994P, 997K, 1,017D, 1,020N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

Protein sequence

>MIA_00111_1
MSNNNNNDNNLIDLPGPSDPFADTPRQSSPQLQQPQQQPSNVHDDDLLSLNDPPYPQSNPRQPAHHESIPLTNLRPIDSA
YENDDLQRPYDPIDNFGPYPSTNAFATPFDDPIEQTPSNDVFLEGSNTNNRNTGIASSYNNLDDQDYLRSGPSQPITSQG
FTHYGNTRKTGISGMYNSMKTRLGLGSAYTEMDLPLTNQGNAAAAHHDDIGSGARASNMNDDKEGSGDFDMRRIWNKLLR
RKQVDPKFLGPRVIFLNNTQANLGHGYKDNHISTTKYNAATFLPKFLFEQFSKYANLFFLFTSCIQQVPNVSPTNRYTTI
GTLAIVLLVSAIKESIEDIKRGNADKELNNSIVEVLNGGVFEKKRWIRVAVGDIIRVNSEEPFPADLVLLSSSEPEGLCY
IETANLDGETNLKIKQALPDTSEIVSPGDLSRISGKLLSEQPNSSLYTYEATLNLDDGNSVREIPLSPDQLLLRGATLRN
TQWIHGLVVFTGHETKLMRNATAAPIKRTAVEHMLNLQIIFLFTILIVLAIISSLGQVIKDRVNYDNLGYLHLVGTNGVK
TFFSDILTYWVLFSNLVPISLFVTVEIVKFYQAYLISSDLDMYYKETDTPAICRTSSLVEELGQIEYIFSDKTGTLTRNI
MEFRSCTIAGHCYADEIPEDKKATVVDGVEVGYSDFDVLRQRMDTHETQVYIREFFTLLAACHTVIPEMKPNGKIKYQAA
SPDEGALVEGAAKLGYKFVVRRPKSITIDIEGQEYVYQLLNILEFNSTRKRMSAIFRCPDGKIRLYCKGADTVIMERLAA
ESEFLTETTTHLEDFAAEGLRTLCLATRLIPDEEYGPWSQVFDKAATTLTNRSEELDKAAELIEREMYLLGATAIEDKLQ
EGVPETIHTLQNAGIKIWVLTGDRQETAINIGMSCKLLSEDMSLLTINKTSFEETQSSIREYLQQIASGGADSEVLALII
DGKSLEYALDPRLELDFLDLAVQCKAVVCCRVSPLQKALVVKLVKRHKKALLLAIGDGANDVSMIQAAHVGVGISGLEGM
QAARSADVSIGQFRFLRKLLLVHGSWSYHRLSKAILYSFYKNIALYMTQFWYVFENGFSGQSIYESWTITFYNVFFTVMP
PFVIGVFDQYISARLLDRYPQLYKLGQAGAFFNVKHFWQWIINGFYHSLLLYFCSTAAFRYGNVLPNGLIADHWTWGTAL
YTTCVLTALLKAALIMNMWNKFTVIAIPGSFLLWLGFFPAYATIAPLVNVSKEYRGVLSHLYSSAVFWAMLLVLPVMCLV
RDFSWKYYRRMYRPSSYHYVQEIQKYNIQDYRPRMEQFQKAIRKVRQVQRMRKQRGFAFSQADEGQSKIIEAYDTTKARG
RYGEMKSLHPQNTIHLHK

GO term prediction

Biological Process

GO:0015914 phospholipid transport

Molecular Function

GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004012 phospholipid-translocating ATPase activity
GO:0005524 ATP binding

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features