MCA_00858_1

Protein

Length

1,356 amino acids

Gene name: DRS2

Description: Trans-golgi network aminophospholipid translocase (flippase)

Browser: contigA:2684108-2688179+

RNA-seq: read pairs 5603, FPKM 51.0, percentile rank 65.8% (100% = highest expression)

Protein function

Annotation:		DRS2	Trans-golgi network aminophospholipid translocase (flippase)
KEGG:	K14802	DRS2	phospholipid-transporting ATPase [EC:3.6.3.1]
EGGNOG:	0QE8C		phospholipid-transporting ATPase
SGD closest match:	S000000024	DRS2	Probable phospholipid-transporting ATPase DRS2
CGD closest match:	CAL0000194034	orf19.6778	Phospholipid-transporting ATPase

Protein alignments

	%id	Aln length
MIA_00111_1	82.85%	1312	MIA_00111_1
A0A0J9XKK8_GEOCN	76.63%	1365	Phospholipid-transporting ATPase OS=Geotrichum candidum GN=BN980_GECA32s00131g PE=3 SV=1
A0A060TC31_BLAAD	72.64%	1290	Phospholipid-transporting ATPase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D36564g PE=3 SV=1
A0A1E3PF95_9ASCO	74.92%	1180	Phospholipid-transporting ATPase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_28338 PE=3 SV=1
Q6C3I4_YARLI	69.33%	1226	Phospholipid-transporting ATPase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E34551g PE=3 SV=1
UniRef50_A0A022VXU5	66.09%	1206	Phospholipid-transporting ATPase n=3 Tax=Trichophyton rubrum TaxID=5551 RepID=A0A022VXU5_TRIRU
Q5ADR3_CANAL	67.86%	1173	Phospholipid-transporting ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6778 PE=3 SV=1
ATC3_YEAST	65.87%	1169	Probable phospholipid-transporting ATPase DRS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DRS2 PE=1 SV=2
A0A1E4TK42_9ASCO	63.22%	1150	Phospholipid-transporting ATPase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_22881 PE=3 SV=1
A0A167E6A2_9ASCO	77.82%	771	Phospholipid-transporting ATPase OS=Sugiyamaella lignohabitans GN=DRS2 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0197

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily IV (IPR006539)

Domains and repeats

Domain
232 - 298
P-type ATPase, N-terminal (IPR032631)
328 - 399
P-type ATPase, A domain (IPR008250)
438 - 479
P-type ATPase, A domain (IPR008250)
575 - 895
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)
949 - 1,048
HAD-like domain (IPR023214)
Domain
240 - 332
P-type ATPase, transmembrane domain (IPR023298)
480 - 601
P-type ATPase, transmembrane domain (IPR023298)
1,042 - 1,272
P-type ATPase, transmembrane domain (IPR023298)
Domain
1,021 - 1,272
P-type ATPase, C-terminal (IPR032630)

1 200 400 600 800 1000 1200 1356

Detailed signature matches

IPR001757

P-type ATPase
1. TIGR01494
  
  965 - 1,075
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
  
  535 - 662
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
IPR006539

P-type ATPase, subfamily IV
1. TIGR01652
  
  245 - 1,280
  
  TIGRFAMs
  TIGR01652 (TIGR01652)
IPR032631

P-type ATPase, N-terminal
1. PF16209 (PhoLip_ATP...)
  
  232 - 298
  
  Pfam
  PF16209 (PhoLip_ATPase_N)
IPR023298

P-type ATPase, transmembrane domain
1. SSF81665 (Calcium A...)
  
  240 - 332
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  1,042 - 1,272
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  480 - 601
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR008250

P-type ATPase, A domain
1. SSF81653 (Calcium A...)
  
  328 - 399
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
  
  438 - 479
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR023214

HAD-like domain
1. SSF56784 (HAD-like)
  
  602 - 618
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  789 - 895
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  949 - 1,048
  
  SUPERFAMILY
  SSF56784 (HAD-like)
IPR023299

P-type ATPase, cytoplasmic domain N
1. SSF81660 (Metal cat...)
  
  613 - 861
  
  SUPERFAMILY
  SSF81660 (Metal cation-transporting ATPase, ATP-binding domain N)
2. G3DSA:3.40.11...
  
  620 - 843
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
  
  575 - 619
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR032630

P-type ATPase, C-terminal
1. PF16212 (PhoLip_ATP...)
  
  1,021 - 1,272
  
  Pfam
  PF16212 (PhoLip_ATPase_C)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  609 - 615
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

567 - 1,051

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,194 - 1,199

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,259 - 1,356

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,115 - 1,134

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 492

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.11...

844 - 1,279

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
G3DSA:2.70.15...

280 - 482

GENE3D
G3DSA:2.70.150.10 (G3DSA:2.70.150.10)
NON_CYTOPLASM... (N...)

1,227 - 1,237

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,161 - 1,171

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,073 - 1,091

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

515 - 544

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF00122 (E1-E2_ATPase)

326 - 516

Pfam
PF00122 (E1-E2_ATPase)
PF13246 (Cation_ATPase)

682 - 775

Pfam
PF13246 (Cation_ATPase)
PR00119 (CATATPASE)

607 - 621

PRINTS
PR00119 (CATATPASE)

871 - 881

PRINTS
PR00119 (CATATPASE)

993 - 1,012

PRINTS
PR00119 (CATATPASE)
TMhelix

1,172 - 1,194

TMHMM
TMhelix (TMhelix)

1,236 - 1,258

TMHMM
TMhelix (TMhelix)

544 - 566

TMHMM
TMhelix (TMhelix)

1,135 - 1,157

TMHMM
TMhelix (TMhelix)

1,201 - 1,223

TMHMM
TMhelix (TMhelix)

492 - 514

TMHMM
TMhelix (TMhelix)

1,092 - 1,114

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

1,172 - 1,193

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,135 - 1,160

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,092 - 1,114

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

545 - 566

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,200 - 1,226

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,238 - 1,258

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,052 - 1,072

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

493 - 514

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd02073 (P-type_ATP...)

247 - 1,153

CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)
mobidb-lite (disord...)

1 - 72

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

phosphorylation si...

609D

phosphorylation site
609D
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)
P-type ATPase sign...

609D

P-type ATPase signature motif
609D, 610K, 611T, 612G, 613T, 614L, 615T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

610K

P-type ATPase signature motif
609D, 610K, 611T, 612G, 613T, 614L, 615T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

611T

P-type ATPase signature motif
609D, 610K, 611T, 612G, 613T, 614L, 615T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

612G

P-type ATPase signature motif
609D, 610K, 611T, 612G, 613T, 614L, 615T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

613T

P-type ATPase signature motif
609D, 610K, 611T, 612G, 613T, 614L, 615T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

614L

P-type ATPase signature motif
609D, 610K, 611T, 612G, 613T, 614L, 615T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

615T

P-type ATPase signature motif
609D, 610K, 611T, 612G, 613T, 614L, 615T
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)
putative ATP bindi...

609D

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

610K

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

611T

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

743F

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

766K

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

767G

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

768A

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

832E

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

879T

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

880G

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

881D

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

969R

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

972P

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

975K

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

995D

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

998N

putative ATP binding site
609D, 610K, 611T, 743F, 766K, 767G, 768A, 832E, 879T, 880G, 881D, 969R, 972P, 975K, 995D, 998N
CDD
cd02073 (P-type_ATPase_APLT_Dnf-like)

Protein sequence

>MCA_00858_1
MSRKDRNNFTDNNSSNDPFSDIHHTQSRDDDLLSLGDSSQGNLSQPGLTNVPTNTTAQRPYDSLDSPYNQSSSNVYSTNA
FATPFDDPGEPSTSNYDPFFGQSSTSNYKNTGVGGSTSANNYNLDDQDYLHPRINSQGYTEYDSKKSGLAGVYNSVKSKL
GLGNTYTEMDLPLTENANSSNRHDLGSGARADLSGDGNVDKDASYDFDLRKTFNKLIGKKEVDPRTLGPRVIYLNDPVSN
SAQSFKDNHISTTKYNVATFLPKFLFEQFSKYANLFFLFTSCIQQVPNISPTNRFTTIGTLAVVLLVSAIKELVEDVKRG
NADKELNNSYVEVLVDGSFQKKRWIKVAVGDILRVNSEEPFPADLVLLSSSEPEGLCYIETANLDGETNLKIKQAVADTS
EIVSPMDLSRISGKLLSEQPNSSLYTYEATLNIDDGNSVREIPVAPDQLLLRGATLRNTQWIHGIVVFTGHETKLMRNAT
AAPIKRTAVEHMLNLQIIFLFCILIVLAIVSSLGEVIKNQVNKDHLGYLQLQGTNAVKTFFSDILTYWVLFSNLVPISLF
VTVEIVKFYQAYLISSDLDMYYKETDTPAICRTSSLVEELGQIEYIFSDKTGTLTRNIMEFKCCSIAGHCYADEIPEDKR
LTVVDGIEVGYNDFTELRQRMDTHETRVYIREFFTLLAACHTVIPEVKPNGKMKYQAASPDEGALVEGAASLGYKFIIRR
PKSITIEIVGDQYEYQLLNILEFNSTRKRMSAIFRCPDGKIRLYCKGADTVILERLAAESDFVNETTTHLEDFAAEGLRT
LCLATRVVPDDEYNKWSVIFDKASTTLTNRSEELDKAAELIEKDMYLLGATAIEDKLQEGVPETIHTLQNAGIKIWVLTG
DRQETAINIGMSCKLLSEDMSLLTINKTNFEETRECIQDFLSQTSGNGNESDVLALIIDGKSLEYALDSRLEKDFLNLAV
QCKAVICCRVSPLQKALVVKLVKRHKKALLLAIGDGANDVSMIQAAHVGVGISGLEGMQAARSADVSIGQFRFLRKLLLV
HGSWSYHRLSKAILYSFYKNIALYMTQFWYVFWNGFSGQSIFESWTITFYNVFFTVMPPFIIGVFDQYVSARLLDRYPQL
YRLGQKGAFFNVRHFWQWIINGFYHSLILYIGSIFAYRYATVQANGLTSDHWVWGTALYTACVLTALGKAALISNMWNKF
TLIAIPGSFLLWLGFLPAYAAIAPLVNVSTEYRGIVSHLYGTLTFWAMIVVLPVMCLIRDFSWKYYRRMYRPISYHYVQE
IQKYNIADYRPRMEQFQKAIRKVRQVQRMRKQRGFAFSQADEGQSRIIEAYDTTKARGRYGEMKSLHPHNTIHLHK

GO term prediction

Biological Process

GO:0015914 phospholipid transport

Molecular Function

GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004012 phospholipid-translocating ATPase activity
GO:0005524 ATP binding

Cellular Component

GO:0016021 integral component of membrane

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Status

Per-residue features