Protein

MIA_00097_1

Length
347 amino acids

Browser: contig01:252476-253706-

Protein function

EGGNOG:0PH6QTIF34Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome (By similarity)
SGD closest match:S000004754TIF34Eukaryotic translation initiation factor 3 subunit I
CGD closest match:CAL0000192484TIF34Eukaryotic translation initiation factor 3 subunit I

Protein alignments

%idAln lengthE-value
A0A0J9XFC4_GEOCN54.925%3352.32e-147Eukaryotic translation initiation factor 3 subunit I OS=Geotrichum candidum GN=TIF34 PE=3 SV=1
MCA_04326_153.470%3896.48e-146MCA_04326_1
A0A161HLB9_9ASCO53.731%3352.28e-138Eukaryotic translation initiation factor 3 subunit I OS=Sugiyamaella lignohabitans GN=TIF34 PE=3 SV=1
A0A060T8H3_BLAAD53.593%3342.20e-132Eukaryotic translation initiation factor 3 subunit I OS=Blastobotrys adeninivorans GN=TIF34 PE=3 SV=1
A0A1E3PSF9_9ASCO49.405%3362.28e-122Eukaryotic translation initiation factor 3 subunit I OS=Nadsonia fulvescens var. elongata DSM 6958 GN=TIF34 PE=3 SV=1
EIF3I_YARLI48.387%3415.85e-120Eukaryotic translation initiation factor 3 subunit I OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TIF34 PE=3 SV=1
EIF3I_CANAL50.000%3421.26e-118Eukaryotic translation initiation factor 3 subunit I OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TIF34 PE=3 SV=1
UniRef50_C4Y7U248.596%3567.37e-114Eukaryotic translation initiation factor 3 subunit I n=8 Tax=Opisthokonta TaxID=33154 RepID=C4Y7U2_CLAL4
EIF3I_YEAST46.450%3381.25e-110Eukaryotic translation initiation factor 3 subunit I OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TIF34 PE=1 SV=1
A0A1E4TK21_9ASCO42.980%3498.17e-101Eukaryotic translation initiation factor 3 subunit I OS=Tortispora caseinolytica NRRL Y-17796 GN=TIF34 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0829
Predicted cleavage: 21

Protein family membership

Domains and repeats

  1. Domain
  2. Repeat
1 50 100 150 200 250 300 347

Detailed signature matches

  1. Family IPR027525
    Eukaryotic translation initiation factor 3 subunit I
    1. MF_03008 (eIF3i)
  2. Domain IPR015943
    WD40/YVTN repeat-like-containing domain
    1. G3DSA:2.130.1...
  3. Domain IPR017986
    WD40-repeat-containing domain
    1. SSF50978 (WD40 repe...)
    2. PS50294 (WD_REPEATS...)
  4. Repeat IPR001680
    WD40 repeat
    1. PF00400 (WD40)
    2. PS50082 (WD_REPEATS_2)
    3. SM00320 (WD40_4)
  5. SITE IPR019775
    WD40 repeat, conserved site
    1. PS00678 (WD_REPEATS_1)

Protein sequence

>MIA_00097_1
MRPLKIQGHSRPLTQVKYNSDGDLLLTVARDNVANVWYSHNGQRLGTLDGHSGAIMSIDVDDQTHLVATGSGDGTARLWD
IKIGKELYAWNTTASTRYVVFSPKGDRLLLVTDENFGRKSKLQIFKLNRENPTQQSEEPELVIENQDGPKAKYLVAAWTY
DSENLVVGLNNGEVKKFSVTGDKKGEAVQTIKAHQEAVSDLQMSLDRTYFITSSRDKLAKLFDSDTLENLHTYEGQAPLN
SACITTVKDFVIVGGGQDASAVTTTADQEGDFKSKIFHKYFEDHLGDVKGHFGPINTLAADPKGRSFVSGGEDGFIRLHH
FDPSYFEFYYDIERRNKEEIAAAVAAN

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003743 translation initiation factor activity
GO:0005515 protein binding

Cellular Component

GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex