Protein

MCA_04326_1

Length
394 amino acids

Gene name: TIF34

Description: Eukaryotic translation initiation factor 3 subunit I

Browser: contigC:2715330-2716878+

RNA-seq: read pairs 7755, FPKM 242.6, percentile rank 90.2% (100% = highest expression)

Protein function

Annotation:TIF34Eukaryotic translation initiation factor 3 subunit I
KEGG:K03246EIF3I translation initiation factor 3 subunit I
EGGNOG:0PH6QTIF34Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome (By similarity)
SGD closest match:S000004754TIF34Eukaryotic translation initiation factor 3 subunit I
CGD closest match:CAL0000192484TIF34Eukaryotic translation initiation factor 3 subunit I

Protein alignments

%idAln lengthE-value
MIA_00097_153.47%3894e-144MIA_00097_1
A0A0J9XFC4_GEOCN50.13%3858e-135Eukaryotic translation initiation factor 3 subunit I OS=Geotrichum candidum GN=TIF34 PE=3 SV=1
A0A060T8H3_BLAAD46.74%3835e-122Eukaryotic translation initiation factor 3 subunit I OS=Blastobotrys adeninivorans GN=TIF34 PE=3 SV=1
A0A161HLB9_9ASCO43.64%3855e-120Eukaryotic translation initiation factor 3 subunit I OS=Sugiyamaella lignohabitans GN=TIF34 PE=3 SV=1
EIF3I_YARLI45.45%3852e-111Eukaryotic translation initiation factor 3 subunit I OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TIF34 PE=3 SV=1
A0A1E3PSF9_9ASCO44.82%3869e-112Eukaryotic translation initiation factor 3 subunit I OS=Nadsonia fulvescens var. elongata DSM 6958 GN=TIF34 PE=3 SV=1
UniRef50_Q0CXH944.65%3838e-107Eukaryotic translation initiation factor 3 subunit I n=9 Tax=Dikarya TaxID=451864 RepID=EIF3I_ASPTN
EIF3I_CANAL43.41%3876e-110Eukaryotic translation initiation factor 3 subunit I OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TIF34 PE=3 SV=1
EIF3I_YEAST40.46%3931e-101Eukaryotic translation initiation factor 3 subunit I OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TIF34 PE=1 SV=1
A0A1E4TK21_9ASCO43.41%3871e-100Eukaryotic translation initiation factor 3 subunit I OS=Tortispora caseinolytica NRRL Y-17796 GN=TIF34 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8070
Predicted cleavage: 21

Protein family membership

Domains and repeats

  1. Domain
  2. Repeat
1 50 100 150 200 250 300 350 394

Detailed signature matches

  1. Family IPR027525
    Eukaryotic translation initiation factor 3 subunit I
    1. MF_03008 (eIF3i)
  2. Domain IPR015943
    WD40/YVTN repeat-like-containing domain
    1. G3DSA:2.130.1...
  3. Domain IPR017986
    WD40-repeat-containing domain
    1. SSF50978 (WD40 repe...)
    2. PS50294 (WD_REPEATS...)
  4. Repeat IPR001680
    WD40 repeat
    1. PF00400 (WD40)
    2. PS50082 (WD_REPEATS_2)
    3. SM00320 (WD40_4)

Protein sequence

>MCA_04326_1
MRPIRLRGHTRPLTQLKYNRDGDLLFSVGRDKIVNVWYSQNGERVGTYIGHTGAVLTVDINPDTSVVATGAGDGTVRLWK
ANTGQELFRWDTTSTPKRVAFSPNGDKLLVVTDENFSLLSTLKVFTIDLSKLQDVPEKIIDNKAESSSTPPDSYLLPQDP
TPVVDIVNNKGKENRFTVGAWSYDGNYVIAGTNAGHIVKYNVEKQDKEMEQYDAEKYGSEDKETRNSNKGEISDARLVLD
QQVHEMAVSDLQMSLDNTYFITSSRDKSAKLFDTDSFKNFSTYEALAPANSAAITAVKDFVIVGGGQDASAVTTSAAQEG
DFKAKFFHKIFEDMLGEVKGHFGPINTLAADPKGRSFASGGEDGYIRLHHFDKAYFDFYYDLELRHKQEQELQA

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003743 translation initiation factor activity
GO:0005515 protein binding

Cellular Component

GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex