Protein
MIA_00096_1
Length
548 amino acids
Browser: contig01:250505-252383+
Protein function
| EGGNOG: | 0PH4R | ATG18 | The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity) |
|---|---|---|---|
| SGD closest match: | S000001917 | ATG18 | Autophagy-related protein 18 |
| CGD closest match: | CAL0000198706 | ATG18 | Autophagy-related protein 18 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_04327_1 | 89.93% | 288 | 3e-169 | MCA_04327_1 |
| A0A0J9X9L1_GEOCN | 74.10% | 278 | 4e-135 | Similar to Saccharomyces cerevisiae YFR021W ATG18 Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway OS=Geotrichum candidum GN=BN980_GECA06s01011g PE=4 SV=1 |
| A0A060T974_BLAAD | 69.89% | 269 | 6e-128 | ARAD1D09416p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D09416g PE=4 SV=1 |
| ATG18_YARLI | 71.79% | 273 | 2e-127 | Autophagy-related protein 18 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ATG18 PE=3 SV=1 |
| UniRef50_Q6C044 | 71.79% | 273 | 4e-124 | Autophagy-related protein 18 n=31 Tax=Fungi TaxID=4751 RepID=ATG18_YARLI |
| A0A1E3PKV4_9ASCO | 64.46% | 287 | 1e-118 | WD40 repeat-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_79335 PE=4 SV=1 |
| A0A1E4TIF3_9ASCO | 61.59% | 276 | 4e-115 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_21901 PE=4 SV=1 |
| ATG18_CANAL | 50.69% | 288 | 8e-91 | Autophagy-related protein 18 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ATG18 PE=3 SV=2 |
| ATG18_YEAST | 62.94% | 143 | 7e-61 | Autophagy-related protein 18 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG18 PE=1 SV=1 |
| A0A167DD30_9ASCO | 60.00% | 170 | 4e-51 | Phosphoinositide binding protein ATG18 OS=Sugiyamaella lignohabitans GN=ATG18 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.4163
Protein family membership
None predicted.
Domains and repeats
-
Domain
-
Repeat
1
50
100
150
200
250
300
350
400
450
500
548
Detailed signature matches
-
-
SSF50978 (WD40 repe...)
-
no IPR
Unintegrated signatures
-
mobidb-lite (disord...)
Protein sequence
>MIA_00096_1 MAAAYLQRSTTRHFHDAINFVNFNQDFSCISVGTKNGYNLFNCDPFGKCFAKVDGGIGIVEMLFCTSLVAVVGVGDQPHL SPRRLKIVNTKRKLNICELTFPTAVLKVKLNRKRLIVLLEEQIYIYDISNMQLLYTIETSPNPQAICALSPSSDNCYLAY PSPAPQSSSPFAFPPHVPAANNLTSPNRTGDVVVFDTLTLQPVNVIEAHKSPLAALTFNSDGNLLATASDKGTIVRVFSI PSATKLYQFRRGTYPSRIFSINFNAASSLLAVSSATETVHIFRLARPGNVQPVPVVTRTEHKHSASTGSQTSPTFPSISS VHSEQQQHQDTQHSEHDNSHSHDNQHSDPSGSPPQEHQNTGEQHQQQNSGENGTTQGDSDSASSLSLDSQATAAAAAILP KLTNHEESVNSLGLDSATDSRKWRLGGRSSPSPGASTPNSTGNGQAATSSMASILRRGSRTLGRQVAGAVGTYLPSAVTE MWEPQRDFAFVKLPGAAGLKSVVAFNAASTRLFAVTSEGYFYQYAIDHAKGGEGQLLQQYSLLDNSEE
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0005515 protein binding
Cellular Component
None predicted.