Protein

MIA_00052_1

Length
562 amino acids

Browser: contig01:140395-142133+

Protein function

EGGNOG:0PHI5PDC1Pyruvate decarboxylase
SGD closest match:S000004034PDC1Pyruvate decarboxylase isozyme 1
CGD closest match:CAL0000201027PDC11Pyruvate decarboxylase

Protein alignments

%idAln lengthE-value
MCA_00335_171.809%5640.0MCA_00335_1
A0A0J9XD52_GEOCN66.250%5600.0Similar to Saccharomyces cerevisiae YLR044C PDC1 Major of three pyruvate decarboxylase isozymes OS=Geotrichum candidum GN=BN980_GECA08s04300g PE=3 SV=1
PDC1_CANAL58.875%5690.0Pyruvate decarboxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDC11 PE=1 SV=2
A0A1E3PK22_9ASCO57.597%5660.0Pyruvate decarboxylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46404 PE=3 SV=1
A0A060TB88_BLAAD59.075%5620.0ARAD1D26004p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D26004g PE=3 SV=1
PDC1_YEAST57.726%5630.0Pyruvate decarboxylase isozyme 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDC1 PE=1 SV=7
UniRef50_P0616957.726%5630.0Pyruvate decarboxylase isozyme 1 n=132 Tax=Ascomycota TaxID=4890 RepID=PDC1_YEAST
Q6C9L5_YARLI58.377%5670.0YALI0D10131p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D10131g PE=3 SV=1
A0A161HH14_9ASCO56.106%5650.0Indolepyruvate decarboxylase 1 OS=Sugiyamaella lignohabitans GN=PDC1 PE=3 SV=1
A0A1E4TLE4_9ASCO54.913%5190.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30685 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2257

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 562

Detailed signature matches

  1. Family IPR012110
    Thiamine pyrophosphate (TPP)-dependent enzyme
    1. PIRSF036565 (Pyruvt...)
  2. Domain IPR029061
    Thiamin diphosphate-binding fold
    1. SSF52518 (Thiamin d...)
  3. Domain IPR012001
    Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
    1. PF02776 (TPP_enzyme_N)
  4. Domain IPR029035
    DHS-like NAD/FAD-binding domain
    1. SSF52467 (DHS-like ...)
    2. G3DSA:3.40.50...
  5. Domain IPR012000
    Thiamine pyrophosphate enzyme, central domain
    1. PF00205 (TPP_enzyme_M)
  6. Domain IPR011766
    Thiamine pyrophosphate enzyme, C-terminal TPP-binding
    1. PF02775 (TPP_enzyme_C)
  7. SITE IPR000399
    TPP-binding enzyme, conserved site
    1. PS00187 (TPP_ENZYMES)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. cd02005 (TPP_PDC_IPDC)
  3. cd07038 (TPP_PYR_PD...)

Residue annotation

  1. TPP binding site c...
  2. PYR/PP interface c...
  3. dimer interface cd...
  4. TPP-binding site c...
  5. dimer interface cd...

Protein sequence

>MIA_00052_1
MSQITVGNYLFNRIKQVGVESIFGLPGDFNLALLDKIYEVPGLRWVGNTNELNAGYAADGYSRINGLSVLITTFGVGELS
TLNAIAGAYAEHVGLVHIVGVPATSSQQKHLLLHHTLGNGDFHVFDRMSAGISEKVYLLTENKDIPALIDDALRTAKLKQ
RPVYIAIPTNIGEIKVPKAALDTPIDFSLPENDPEAELEALEEVEKSIAAAKNPIILVDACAYRHGAVEETNALAKLTKF
SVFTTPMGKSVIDEDYERYGGVYVGSLSSPEVFKAVEAADLILSVGALLSDFNTGSFTYSYKTKNIIEFHSNYIQIRRAT
YENVSMKPLLAKLVSQLTPPDLPLAPVPKLVRQPADPADESPLTHKYLWPRISGFLRSGDIIITETGTSSFGVTSIVYPA
KVNGISQVLWGSIGYSVGCALGAALAAQEQDPSRRVLLFVGDGSLQLTLTAISTMVRWKTNPYLFVLNNDGYTIERLIHG
PESGYNDIKSWDHQLILPLFKADPKTSESLVVKTKKDLDSLFTDEEFKVPNKIRLIELILDRLDAPDSLYKQGELTSKTN
AS

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0016831 carboxy-lyase activity
GO:0030976 thiamine pyrophosphate binding

Cellular Component

None predicted.