MCA_06495_2
Gene name: PYC2
Description: Pyruvate carboxylase 2
Browser: contigD:4389895-4394121-
RNA-seq: read pairs 20990, FPKM 218.1, percentile rank 89.1% (100% = highest expression)
Protein function
| Annotation: | PYC2 | Pyruvate carboxylase 2 | |
|---|---|---|---|
| KEGG: | K01958 | PC | pyruvate carboxylase [EC:6.4.1.1] |
| EGGNOG: | 0QEBK | PYC1 | Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) |
| SGD closest match: | S000000422 | PYC2 | Pyruvate carboxylase 2 |
| CGD closest match: | CAL0000188525 | PYC2 | Pyruvate carboxylase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A0J9X9G6_GEOCN | 85.41% | 1179 | 0.0 | Pyruvate carboxylase OS=Geotrichum candidum GN=BN980_GECA06s04762g PE=4 SV=1 |
| MIA_02272_1 | 88.16% | 1115 | 0.0 | MIA_02272_1 |
| Q6CAV2_YARLI | 80.91% | 1168 | 0.0 | Pyruvate carboxylase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C24101g PE=4 SV=1 |
| A0A1E3PFE4_9ASCO | 78.60% | 1168 | 0.0 | Pyruvate carboxylase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83995 PE=4 SV=1 |
| A0A060TC34_BLAAD | 79.11% | 1168 | 0.0 | Pyruvate carboxylase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D32912g PE=4 SV=1 |
| A0A1D8PLY4_CANAL | 76.06% | 1178 | 0.0 | Pyruvate carboxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PYC2 PE=4 SV=1 |
| A0A1E4TIT0_9ASCO | 78.52% | 1164 | 0.0 | Pyruvate carboxylase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30005 PE=4 SV=1 |
| PYC2_YEAST | 75.09% | 1168 | 0.0 | Pyruvate carboxylase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PYC2 PE=1 SV=2 |
| A0A167FK68_9ASCO | 80.37% | 1075 | 0.0 | Pyruvate carboxylase 2 OS=Sugiyamaella lignohabitans GN=PYC2 PE=4 SV=1 |
| UniRef50_C5PE04 | 72.59% | 1164 | 0.0 | Pyruvate carboxylase n=40 Tax=Fungi TaxID=4751 RepID=C5PE04_COCP7 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0255
Protein family membership
- Pyruvate carboxylase (IPR005930)
Domains and repeats
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Domain
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Domain
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Domain
Detailed signature matches
no IPR
Residue annotation
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catalytic residues...
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active site cd07937
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metal binding site...
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homodimer binding ...
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carboxyltransferas...
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biotinylation site...
Protein sequence
>MCA_06495_2 MAETDTKEYISTLDEEVATATSVNQIRADSSILGSMNKILVANRGEIPIRIFRTAHELSMLTVAIFAHEDRLSMHRLKAD EAYAIGPRGKYTPVQAYLQIDEIIKIAIRHGVNMIHPGYGFLSENSEFARKVVDAGMIWIGPPAEVIESVGDKVSARHLA EKCNVPVVPGTPGPIEKVEDAQAFVDKYGYPVIIKAAFGGGGRGMRVVREGDNISDAFQRATNEAKAAFGNGTVFIERFL DRPKHIEVQILADNEGNVVHLFERDCSVQRRHQKVVEIAPALKLPEDVRNAILTDAVKLATTAKYRNAGTAEFLVDNQNR HYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGATLEKLGLTQNKIKYRGFAIQCRITTEDPAKNFQPDTGKIEVYRS SGGNGVRLDGGNGFAGAIISPHYDSMLVKATCSGSTYEIARRKMLRALIEFRIRGVKTNIPFLLALLTNDTFIKGDCWTT FIDDTPSLFEMMTSQNRGQKILAFLAELIVNGSQVVGQLGVPKLTTDVIIPDLIDRETGEAIDVSLPSTKGWRQILVDEG PEAFAKAVRKFDGTLLMDTTWRDAHQSLLATRVRTYDLLQIAPATSHALSGAFALECWGGATFDVAMRFLHEDPWARLRK LRKAVPNIPFQMLLRGANGVAYSSLPDNAIDQFVAEAKKNGVDIFRVFDALNDLEQLKVGVDAVKKAGGVVEATVCYSGD MLNPKKKYNLEYYLKVVDKIVEMGTHILGIKDMAGTMKPAAATKLVGSIRAKYPDLPIHVHTHDSAGTGVSSMTACALAG ADVVDAASNSMSGMTSQPSISAILASLEGRVETGLDSNLIKDIDAYWAQMRLLYSCFEADLKGPDPEVYDHEIPGGQLTN LLFQAQQVGLGTKWKETKEAYREANMLLGDIVKVTPTSKVVGDLAQFMVSNKLSYQDVLDKASSLDVPASVLDFFEGLMG QPYGGFPEPLRTQILRNQRPKLTERPGKFLKPLDLAAIKADLEKRFGGITGCDVASYNMYPKVYEEFRKYTDKYGDLSII PTQYFLAPPEIGKEFAVEIQQGKILIIKLLAVGELSTQTGTREVYFELNGEMRKVTVDDKNASVETITRPKADPHNPNEI GAPMAGVVVEVRVKEGSDVKKGDPVVVLSAMKMEMVVSANTSGKVSEVLVKDGDSVDGSDMLCKILKA
GO term prediction
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006094 gluconeogenesis
Molecular Function
GO:0003824 catalytic activity
GO:0004075 biotin carboxylase activity
GO:0004736 pyruvate carboxylase activity
GO:0005524 ATP binding
GO:0009374 biotin binding
GO:0046872 metal ion binding
Cellular Component
None predicted.