Protein

MCA_06377_1

Length
189 amino acids

Gene name: GUK1

Description: Guanylate kinase

Browser: contigD:4024846-4025626+

RNA-seq: read pairs 3128, FPKM 203.4, percentile rank 88.3% (100% = highest expression)

Protein function

Annotation:GUK1Guanylate kinase
KEGG:K00942E2.7.4.8 guanylate kinase [EC:2.7.4.8]
EGGNOG:0PHNNPGUG_02674guanylate kinase
SGD closest match:S000002862GUK1Guanylate kinase
CGD closest match:CAL0000178615GUK1Guanylate kinase

Protein alignments

%idAln lengthE-value
MIA_00822_179.14%1872e-110MIA_00822_1
A0A0J9XFH8_GEOCN75.53%1888e-107Similar to Saccharomyces cerevisiae YDR454C GUK1 Guanylate kinase OS=Geotrichum candidum GN=BN980_GECA13s02584g PE=3 SV=1
A0A1E3PF16_9ASCO72.58%1863e-102Guanylate kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_27567 PE=4 SV=1
A0A1D8PNS0_CANAL73.51%1854e-99Guanylate kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GUK1 PE=3 SV=1
UniRef50_A0A1D8PNS073.51%1859e-96Guanylate kinase n=21 Tax=Eukaryota TaxID=2759 RepID=A0A1D8PNS0_CANAL
A0A060SZN7_BLAAD69.52%1875e-99ARAD1C09702p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C09702g PE=4 SV=1
Q6CBQ9_YARLI69.02%1841e-94YALI0C16434p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C16434g PE=3 SV=1
KGUA_YEAST68.62%1886e-94Guanylate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GUK1 PE=1 SV=2
A0A167E6M5_9ASCO72.94%858e-40Guanylate kinase OS=Sugiyamaella lignohabitans GN=GUK1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9698
Predicted cleavage: 14

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 20 40 60 80 100 120 140 160 189

Detailed signature matches

  1. Family IPR017665
    Guanylate kinase
    1. TIGR03263
    2. MF_00328 (Guanylate...)
  2. Domain IPR008145
    Guanylate kinase/L-type calcium channel beta subunit
    1. SM00072 (gk_7)
    2. PF00625 (Guanylate_kin)
  3. Domain IPR008144
    Guanylate kinase-like domain
    1. PS50052 (GUANYLATE_...)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. SITE IPR020590
    Guanylate kinase, conserved site
    1. PS00856 (GUANYLATE_...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.30.63.10
  3. G3DSA:3.40.50...
  4. cd00071 (GMPK)

Residue annotation

  1. G-X2-G-X-G-K cd00071
  2. catalytic site cd0...

Protein sequence

>MCA_06377_1
MVGRPIVISGPSGSGKSTLLKRLLKEYPNKFGFSVSHTTRSPRPGEVNGKDYHFVTVESFKNLIDNNGFIEWAQFSGNFY
GTSIAAVKDVREKQNKTCILDIDMQGVKSVKKTNLNARFLFLSPPSLEILRERLQGRGTETQESLEKRLKQAELEMEYSK
EEGAHDKIIINDDLERAYKEFKDFMLAED

GO term prediction

Biological Process

GO:0006163 purine nucleotide metabolic process

Molecular Function

GO:0004385 guanylate kinase activity

Cellular Component

None predicted.