Protein
MCA_06234_1
Length
505 amino acids
Gene name: DDI1
Description: DNA damage-inducible protein 1
Browser: contigD:3632149-3633667+
RNA-seq: read pairs 2264, FPKM 55.3, percentile rank 67.5% (100% = highest expression)
Protein function
| Annotation: | DDI1 | DNA damage-inducible protein 1 | |
|---|---|---|---|
| KEGG: | K11885 | DDI1 | DNA damage-inducible protein 1 |
| EGGNOG: | 0PI87 | DDI1 | Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control and may be involved in the regulation of exocytosis (By similarity) |
| SGD closest match: | S000000945 | DDI1 | DNA damage-inducible protein 1 |
| CGD closest match: | CAL0000199868 | DDI1 | Ddi1p |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_05093_1 | 56.52% | 368 | 2e-131 | MIA_05093_1 |
| A0A0J9X6S1_GEOCN | 51.56% | 353 | 4e-116 | Similar to Saccharomyces cerevisiae YER143W DDI1 DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion OS=Geotrichum candidum GN=BN980_GECA03s02826g PE=4 SV=1 |
| UniRef50_A0A0J9X6S1 | 51.56% | 353 | 8e-113 | Similar to Saccharomyces cerevisiae YER143W DDI1 DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X6S1_GEOCN |
| A0A060T043_BLAAD | 49.70% | 336 | 7e-107 | ARAD1C05258p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C05258g PE=4 SV=1 |
| A0A167DSM5_9ASCO | 45.82% | 347 | 1e-95 | Ddi1p OS=Sugiyamaella lignohabitans GN=DDI1 PE=4 SV=1 |
| DDI1_YARLI | 34.83% | 333 | 4e-60 | DNA damage-inducible protein 1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=DDI1 PE=3 SV=1 |
| A0A1D8PFX6_CANAL | 36.68% | 349 | 3e-56 | Ddi1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DDI1 PE=4 SV=1 |
| DDI1_YEAST | 33.33% | 354 | 6e-54 | DNA damage-inducible protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DDI1 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0511
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
50
100
150
200
250
300
350
400
450
505
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
cd01769 (UBL)
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cd14309 (UBA_scDdi1...)
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mobidb-lite (disord...)
Residue annotation
-
Ubq - UCH interact...
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Ubq - E2 interacti...
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Ubq - CUE interact...
-
Catalytic residue ...
-
catalytic motif cd...
Protein sequence
>MCA_06234_1 MKLLLSLDRQDQFITVEVALDMTFADFMAYIEAESGIPPSAQSLVFQGKHIDLVSEEQRNQPLSTLPFSEGDIVQVQDLT PVDAPPPRPSGRTQGSSSNPVTIPLDYTAEDLNKLYAEFDRIRDQMLANPVVRDGVFQRYPQLETVYQDPSAFREQMLAI EKQRVKRELEKQAAMKKLQDDPYDPESQELILQAIREEAIMENFHAAMENNPEAFASVTMLFINTVVNKHPVKAFVDSGA QATIMSPSCAEACGIAHLIDKRFQGMAMGVGTAKILGRIHSVPIQIGQEFLDTSFTVMEGKGVDFLLGLDMLKKHRAIIN LQTNELEITGIKVPFLPEAEIPKTGLFSPQSASNNNVGGGDQQAKTISSSNLGSSSSSTAFSGTGRTLGSVGGSGSSSGS RSSNNAQQRPSSSSSATSSATVASTSASSSFKPVSSISGPSSSSSSSSSNTRFAAAQPSPRQTQFAENDVKQLMDLGFSR EEAIQSLTVSGGNVEHAAALLFNNF
GO term prediction
Biological Process
GO:0006508 proteolysis
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
GO:0005515 protein binding
Cellular Component
None predicted.