Protein

MCA_05827_1

Length
694 amino acids

Gene name: HCS1

Description: DNA polymerase alpha-associated DNA helicase A

Browser: contigD:2436895-2438980-

RNA-seq: read pairs 615, FPKM 10.9, percentile rank 27.4% (100% = highest expression)

Protein function

Annotation:HCS1DNA polymerase alpha-associated DNA helicase A
KEGG:K19783HCS1 DNA polymerase alpha-associated DNA helicase A [EC:3.6.4.12]
EGGNOG:0PFJAFG06867.1DNA helicase
SGD closest match:S000001500HCS1DNA polymerase alpha-associated DNA helicase A
CGD closest match:CAL0000193898orf19.6199ATP-dependent 5'-3' DNA helicase

Protein alignments

%idAln lengthE-value
A0A0J9X5M0_GEOCN60.46%6980.0Similar to Saccharomyces cerevisiae YKL017C HCS1 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis OS=Geotrichum candidum GN=BN980_GECA03s02870g PE=4 SV=1
MIA_05159_160.09%6890.0MIA_05159_1
A0A1E3PH35_9ASCO53.55%6910.0DNA helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_26851 PE=4 SV=1
A0A167FYS7_9ASCO51.42%7020.0ATP-dependent 5'-3' DNA helicase HCS1 OS=Sugiyamaella lignohabitans GN=HCS1 PE=4 SV=1
UniRef50_A0A167FYS751.42%7020.0ATP-dependent 5'-3' DNA helicase HCS1 n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A167FYS7_9ASCO
A0A060T056_BLAAD52.85%6850.0ARAD1C05478p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C05478g PE=4 SV=1
Q6CFH6_YARLI47.67%6880.0YALI0B06897p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B06897g PE=4 SV=1
Q5AAW1_CANAL42.47%7300.0ATP-dependent 5'-3' DNA helicase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6199 PE=4 SV=1
HCS1_YEAST43.97%7057e-179DNA polymerase alpha-associated DNA helicase A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HCS1 PE=1 SV=1
A0A1E4TKE7_9ASCO41.85%6695e-164Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_84103 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0487

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 694

Detailed signature matches

  1. Family IPR004483
    Helicase SMUBP-2/Hcs1-like
    1. TIGR00376
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. SM00487 (ultradead3)
  3. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  4. Domain IPR003593
    AAA+ ATPase domain
    1. SM00382 (AAA_5)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. PF13086 (AAA_11)
  3. PF13087 (AAA_12)
  4. cd00046 (DEXDc)
  5. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...

Protein sequence

>MCA_05827_1
MVSDTPVTLSTQFSSALIEEKQIDIDETAKLLESKSPKQLAKKGLAIINLSISSLKTGMGGRTIMTLELDPAYSSKGQDI
QLGDIRTGDIVRVSPLSAATDSKKKGSQGKAKKPVSSSKSNESAQLFVDGVVSINAHSLSIAVDETFSDTVPLLPSRLWI
VKLTNIATYKRMEFALKGLETLKDPTRIQSILLGNTTPSIPASLPQLEFFDTTLNDPQKEAVRFAMSSSEVTLIHGPPGT
GKTYTLIEIVRQLIKQKKRVLICGPSNISVDNIVERLHPHMKDKDKLIRIGHPARLLQSTRSHALDIVSKSSEHSQVIRE
IQQEIDQNLGKISKTKSGMERRKIYGDIKELRKDYRQREAKVLTNIISAAEVVVSTLHGAGSYSLRNAKKYKESSKPLFD
ALIIDEVSQSLEPQCWIPIIDFPDITKLIVAGDNKQLPPVVMTKSIKYQKILERTLFDRVEKFGFGKDIIKLLPIQYRMN
KLIMEFPSKMMYQNKLIADKSVADIILSDYPHVEKTEETESPVVWIDTQGDDFPEAANDEDDKSQKDKLFEFSKSNENEA
YLVRNYAYMLVEKGVDPSTIGIIAPYSAQISIISQIVHEKYPTIEIATVDGFQGREKDVIILSLVRSNEKGEVGFLGEER
RLNVAMTRPKRHLCIVGNSETISRGSKFLKEWVKWGEDNAYIQFPDISEVLQSQ

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003677 DNA binding
GO:0005524 ATP binding

Cellular Component

None predicted.