Protein

MCA_05819_1

Length
1,272 amino acids

Gene name: SKI2

Description: Antiviral helicase SKI2

Browser: contigD:2420087-2423967+

RNA-seq: read pairs 2227, FPKM 21.6, percentile rank 43.4% (100% = highest expression)

Protein function

Annotation:SKI2Antiviral helicase SKI2
KEGG:K12599SKI2 antiviral helicase SKI2 [EC:3.6.4.-]
EGGNOG:0PHEFFG02781.1helicase (ski2
SGD closest match:S000004390SKI2Antiviral helicase SKI2
CGD closest match:CAL0000185019SKI2SKI complex RNA helicase subunit

Protein alignments

%idAln lengthE-value
MIA_05155_160.76%12820.0MIA_05155_1
A0A0J9XI75_GEOCN59.56%12290.0Similar to Saccharomyces cerevisiae YLR398C SKI2 Ski complex component and putative RNA helicase OS=Geotrichum candidum GN=BN980_GECA19s00120g PE=4 SV=1
A0A060SXD2_BLAAD55.20%12500.0ARAD1A03146p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A03146g PE=4 SV=1
UniRef50_U4L5A648.89%12620.0Similar to Uncharacterized helicase C550.03c acc. no. O59801 n=210 Tax=Fungi TaxID=4751 RepID=U4L5A6_PYROM
A0A1E3PQU0_9ASCO57.96%9920.0Antiviral helicase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_80957 PE=4 SV=1
Q5A337_CANAL49.44%12400.0SKI complex RNA helicase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SKI2 PE=4 SV=1
SKI2_YEAST46.95%12800.0Antiviral helicase SKI2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SKI2 PE=1 SV=2
A0A167DAB9_9ASCO55.59%6530.0SKI complex RNA helicase subunit SKI2 OS=Sugiyamaella lignohabitans GN=SKI2 PE=4 SV=1
Q6CH23_YARLI50.36%6910.0YALI0A13519p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A13519g PE=4 SV=1
A0A1E4T9N9_9ASCO34.54%9966e-158Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_58742 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0361

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1272

Detailed signature matches

  1. Family IPR016438
    ATP-dependent RNA helicase Ski2
    1. PIRSF005198 (SKI2)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  6. Domain IPR025696
    rRNA-processing arch domain
    1. PF13234 (rRNA_proc-...)
  7. Domain IPR012961
    ATP-dependent RNA helicase Ski2, C-terminal
    1. SM01142 (DSHCT_2)
    2. PF08148 (DSHCT)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. cd00046 (DEXDc)
  4. cd00079 (HELICc)
  5. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. putative Mg++ bind...
  3. nucleotide binding...
  4. ATP-binding site c...

Protein sequence

>MCA_05819_1
MSIEEAIDAIRTKSANIPSDAHIIPKLKPADPEELENDELSNENLIKKFLTPSAQFSNQWLDRLQELPKVDIQSNSLQLF
TAPEYKSVTGVKFDRYGLEGKIVGYSEYTAPSEFSTKNAKNSLSINREPSSKADMVKGRPGFMPFAPGGLVSAQELTGHS
DINISRDDNGLYSSAPGLSRGITEHFDAKTSHGGVEDKEFMAPTLFKESQESDDDEEDIEDLDDESEVVDLANNLDELIL
EKDKDNKTAKVSTKIYSEDIDNLLPNEITFGRIKSTIDKIPKVKEWAHNVDVNKTINNFHELVPSMAKEFPFELDTFQKE
AVYHLEQGDSVFVAAHTSAGKTVVAEYAIAMAIRNNTKAIYTSPIKALSNQKFRDFKEIFDDVGILTGDVQINPEASCLI
LTTEILRSMLYRGADLIRDVECVIFDEVHYVNDQDRGVVWEEVIIMLPEHIKLILLSATVPNTFEFGNWVGRTKQKDIYV
ISTPKRPVPLEHYIWTKNRQIKIVDADKKFLEDGYKTVCNLINPPPPKGDDRNGKGGGQGQGGRGGSARGGGRGGRGGRG
GRGGRGGGQLFIPSGGTSYGNQNRRFNSNTHGKTTFIQLLTHLRKENLLPAVIFVFSQKKATEYAQMLQSIDYCTNREKS
EIRMFVDQAISRLKEEDRDLPQIHFVSELLSRGIGIHHGGLLPIVKEIIEILFAKSLVKVLFATETFAMGLNLPTKTVIF
ASTRKHDGHSFRDLLPGEYTQMAGRAGRRGLDTFGTVMLMVSDSPPPADDLKKLILGTPTKLKSQFRLTYNMILNLLRIE
ALRIEEMIKRSFSENANQVMLPEHQKNVKLKEESLAKLTREKCSNCDENLEKFAAAVKQEREIYQEILDASIRLYNAKNL
FSRGRLIIFKLPNGVRMVGIILNFVAGSRAFTVLGASDSTPDPSDKVPYYSMIPGYCERNMNTRFKVASRYKIYRISLSD
IEFIVRIQLRSEIDGYNNPSSKSFKELTKELKVAFVYQNKWNEATNKNISNTLDIASKQEERKKLIKELATFKCIKCPKF
VQHYTIASEILCIEDQINGLKQLISSENMELLPDYEQRVAVLQDLNYIDESQNVLLKGRVACEISTGFELIITELVLDNF
LASYEPEEIVALLSVFLFQGSNKDNGAPSKSVTPKLDIGRARIVEVVEQVLGVFEKYNVLVTPEEAEFLEKDRFALMEPV
YEWGRGMAFKEIMRMTDVPEGTIVRVITRLDEVCRQVMNAAKIIGDTTLYDKMAVAQEKIKRDIVFCASLYL

GO term prediction

Biological Process

GO:0006401 RNA catabolic process

Molecular Function

GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

Cellular Component

None predicted.